Aderans

[jman91]

bump 10 charrrrrrrrrrrrrrrrrrrrrr

[Desmond84]

Yeah, it's definitely working! I'm approaching the 5th month now!

My hair shedding has returned to 2-3 years ago (a hair here or there) and my temples look a lot better!

The problem is when I drink coffee/alcohol, I get a bit of pain down there and my libido isn't where it was pre-fin. My erections are also a bit less full

[Conpecia]

uhhh dude tell me about it!

Something just doesn't feel right when I take it! I don't know how to explain it...I only take 0.25mg every 4 days!

Does that have any effect? I have been taking .25 every three days and I've been told it won't help but my shedding did stop. Unfortunately even at tiny doses spread out there are still ridiculous sides.

I'm going to try to counter the gyno side with Myomin.

[yeahyeahyeah]

uhhh dude tell me about it!

Something just doesn't feel right when I take it! I don't know how to explain it...I only take 0.25mg every 4 days!

And you are maintaining?

[Desmond84]

uhhh dude tell me about it!

Something just doesn't feel right when I take it! I don't know how to explain it...I only take 0.25mg every 4 days!

[jgold]

I agree but propecia is just too sketchy. I get sides from it that just aren't worth even touching it again. I swear the sides must effect at least 30% of the people who take it. At least.

[Desmond84]

Hey guys,

Here's a very critical study I found that directly relates to how effective future treatments will be for us who have already started going through MPB:

Irreversibility of hair follicle changes after 30 months of Androgenetic Alopecia.

Konstantinova N, Korotkii N.G, Sharova N, Barhunova E, Gaevski D. Nioxin Research Inc, Atlanta, USA Moscow Medical University 2001

We studied horizontal and vertical biopsy from 15 caucasian 24-41 year old males diagnosed with bitemporal recession Androgenetic Alopecia (AA) for 1.5 –18 years (average 7.4 years). All 15 biopsies were stained with H&E, Van Gieson and with other collagen specific stainings.

1. Eleven pts with AA longer than 3 years had perifollicular fibrosis - collagen fibers were compact and formed a small scar-like formation around each anagen hair follicle(HF). Two patients - 33 year old with 18 month AA and 23 year old with 20 month AA did not have these hair follicle changes. Two 26-year-old patients with 30 and 36 month AA respectively were found to have some not so severe collagen fiber changes.

2. Infundibulum of HF dilatated 124-192 mm and most of them covered with keratinazed plug lacking normal hair shaft growth.

3. Decreased number of hair follicles 1.75-2,45 per sq. mm from 3.5-5 per sq. mm in control group.

4. None of anagen HF was situated in subcutaneous fat. We showed a correlation between length of the AA and severity/ thickness of perifollicular fibrosis.

The result of this study is that any treatment of AA is recommended to start earlier than 30 months from first signs of AA. This should prevent irreversible collagen changes associated with “fibrotic incapsulation” of most anagen HF in involved areas, which usually leads to loss of normal blood supply, innervation, and subsequent miniaturization and prevention of hair from normal cycling.


This is why it is vital for all of us to do everything we can to hang on to as much hair as possible until these treatments come out!

P.S. Artista thx for all your support brother. I wouldn't be doing so much research if it wasn't for you and everyone elses support!

Cheers

[baldybald]

Aderans will give a better results than Histogen

[rdawg]

They have to finish Phase 2 in April 2013, submit an IND for Phase 3 to FDA and then enrol around 3000 subjects. All in all, FDA may take around 3 months.

The question is how long will they take to find 3000 participants!

Sounds like they should start by september/october 2013.

3000 participants shouldnt take more than a month or two to find.

Or that's true, they could do 1500 in mid-2013, then the rest by mid 2014.

[Artista]

Desmond,,your ongoing activities here are very appreciated. Thanks again

[neversaynever]

That's what I mean!

It might take them over a year to get to 3000, which means even more waiting!

Either way, if they go into phase 3, its a huge huge step forward. Previous attempts have not reached phase 3.

Also, if they start mid 2013 and keep recruiting for another year. Finally reach 3000 in mid 2014, it means those first people treated will start showing results. Which means they will know early on if its a winner.

Wish I was 2 years younger!

[Desmond84]

3000 is a huge number for a injection process. I expect theyll start at the earliest late 2013. Remember it would be staggered.

They might inject the first subjects even in mid 2013 and keep recruiting. The final subject might be injected in early 2014. Making the finish at early 2015, which for me means 2016 release date.

That's what I mean!

It might take them over a year to get to 3000, which means even more waiting!

[Desmond84]

Desmond84. Do you think Aderans product Ji gami will be superior to Histogen? Although they work in different ways. What are your thoughts? You sound very knowledgeable in these future techniques.

To be honest, superior is the wrong word...these TWO treatments will serve different purposes:

- Aderans is meant to maintain the hair you have PERMANENTLY

- Histogen will be the growth stimulant (aka Minoxidil on steroids! LOL)

So, for us who have gone through MPB already we will probably need both treatments.

On the plus side, you will be able to dump your Propecia once you get the Aderans done

Histogen will be used to grow back some of your temple hairs/crown so that you can hopefully avoid a hair transplant!

[neversaynever]

I tell you what though...if they start Phase 3 before 2014, you can be sure we can have this product available sometime in 2015!

Oh god, please make sure they do!

3000 is a huge number for a injection process. I expect theyll start at the earliest late 2013. Remember it would be staggered.

They might inject the first subjects even in mid 2013 and keep recruiting. The final subject might be injected in early 2014. Making the finish at early 2015, which for me means 2016 release date.

[HARIRI]

Desmond84. Do you think Aderans product Ji gami will be superior to Histogen? Although they work in different ways. What are your thoughts? You sound very knowledgeable in these future techniques.