Aderans

[Desmond84]

Oh man I just can't believe we've gone from early 2014 to early 2017.

I can kind of undrestand why the old timers are so negative

[Desmond84]

OK, I just did a bit of reading and found the following: The average time from completion of Phase 3 trials to FDA approval has dropped from 30 months (Late 80's) to 10-15 months (2005+).

So assuming Phase 3 takes around 2 years and FDA approval 1 year, we should have Aderans on the market by late 2016 to early 2017!



Here's the FDA link if you wanna read about it:

http://www.fda.gov/AboutFDA/ReportsManualsForms/Reports/UserFeeReports/PerformanceReports/PDUFA/ucm209349.htm

[Desmond84]

your hair was "DHT resistant" before you started balding. Stop your BS. No one is interest in your combinations

1. Your hairs were DHT resistant because a specific gene wasn't activated yet. This gene/s get activated in different ages in different ppl.

2. Androgen receptors have only been found on the dermal papillae (DP) cells of hair follicles. That's what Aderans is replacing, so yes it definitely is possible!

Realistic aderans release date: May 2019

Could it really take 6 years to finish Phase III and get FDA approval?

[neversaynever]

Realistic aderans release date: May 2019

id say 2017. Assuming they start phase 3 in early 2014.

[Person]

Realistic aderans release date: May 2019

[neversaynever]

your hair was "DHT resistant" before you started balding. Stop your BS. No one is interest in your combinations

Well whatever the malfunction is, in theory the new cells should not have the same malfunction, unless the problem is in the environment.

You think you're gonna hurt my feelings with that attitude?

[2020]

your hair was "DHT resistant" before you started balding. Stop your BS. No one is interest in your combinations

[neversaynever]

If possible, we need to pester Spencer to interview this guy and take some of our questions.

[neversaynever]

I still have high hopes for Histogen though. Noone has a treatment like theirs, and in combination with aderans? Who knows.

[Desmond84]

A few thoughts,

1. MODERATORS of this forum need to step in and control the discussion so that it stays on topic and refrains from abuse. It is VERY annoying when there is news like this and there is page after page after page of talk which has NOTHING to do with Aderans.

2. My personal view is that Aderans have knocked the socks of Histogen and Repicel. Their trial is huge and their photos show CLEAR re-growth. Something I cant really see in Histogens macro shots.

3. OK, so theyre not creating new follicles but this is a huge step forward. Between DHT, BDGF, TGFbeta1, PGE2, PGD2 and so much more, there is no way we will develop a therapy that fixes the signalling problem that makes us bald. Cell multiplication and bio-engineered hairs are the only real possible 'cure'. Aderans are achieving re-growth that is visible after just one injection. And they seem active in finding out just how many of those cells are working and how many are not. Its a big big plus. They have proven that cells can be multiplied to provide a visible change. How can that not be a huge step towards a cure?

4. Are those hairs now DHT resistant? Is that signalling issue now resolved? Essentially those shrinking hairs have inducted these new cells. The next big step is for them to find out how many of the injected cells are actually being inducted and possibly subjecting transformed hair to some kind of "DHT test"?

5. Spencer needs to interview this guy. Id say as a top priority. If he, or a moderator is reading this, please oblige!

People might play down Aderans regrowth but I would pay £20k right now if it was available. Sorry to NW7s and NW6s but there are plenty of people around with plenty of hair left that they can save. Is their a video available of the questions that audience went on to ask him?

You're so right! Definitely as close as we can get to a cure before 2020.

Regarding DHT resistance: I suppose, if the 2 year follow ups show hair count maintenance then we can safely assume they are DHT resistance

[neversaynever]

OK guys, time to start talking about release date:

As most of you heard on the presentation, Aderans has given up on reaching the "70% response rate" target and instead are looking for genetic markers that will indicate whether you're a responder or not.

So what does this mean for their release date?

How long do you suspect this will take?

When do you think Phase 3 will start?

What worries me is, genetic markers were NOT on their timeline schedule back in 2010. Does this mean they are lagging behind more than 1 year as initially thought?

Genetic markers shouldnt worry you. It at least means they are pro-active in vastly improving the current results. With markers they can track the new cells and find out the % of cells being inducted and maybe the conditions in which induction is optimal. Phase 3 wont be for a while. Phase 2 isnt quite done yet and they have some big planning and research to do.

[Desmond84]

Alf, I just wanna get this hair loss over and done with! I can't wait till I can safely dump my Propecia

You could be right actually. They probably know already what these genetic markers are! Any estimates on year of release?

[neversaynever]

A few thoughts,

1. MODERATORS of this forum need to step in and control the discussion so that it stays on topic and refrains from abuse. It is VERY annoying when there is news like this and there is page after page after page of talk which has NOTHING to do with Aderans.

2. My personal view is that Aderans have knocked the socks of Histogen and Repicel. Their trial is huge and their photos show CLEAR re-growth. Something I cant really see in Histogens macro shots.

3. OK, so theyre not creating new follicles but this is a huge step forward. Between DHT, BDGF, TGFbeta1, PGE2, PGD2 and so much more, there is no way we will develop a therapy that fixes the signalling problem that makes us bald. Cell multiplication and bio-engineered hairs are the only real possible 'cure'. Aderans are achieving re-growth that is visible after just one injection. And they seem active in finding out just how many of those cells are working and how many are not. Its a big big plus. They have proven that cells can be multiplied to provide a visible change. How can that not be a huge step towards a cure?

4. Are those hairs now DHT resistant? Is that signalling issue now resolved? Essentially those shrinking hairs have inducted these new cells. The next big step is for them to find out how many of the injected cells are actually being inducted and possibly subjecting transformed hair to some kind of "DHT test"?

5. Spencer needs to interview this guy. Id say as a top priority. If he, or a moderator is reading this, please oblige!

People might play down Aderans regrowth but I would pay £20k right now if it was available. Sorry to NW7s and NW6s but there are plenty of people around with plenty of hair left that they can save. Is their a video available of the questions that audience went on to ask him?

[Alf]

OK guys, time to start talking about release date:

As most of you heard on the presentation, Aderans has given up on reaching the "70% response rate" target and instead are looking for genetic markers that will indicate whether you're a responder or not.

So what does this mean for their release date?

How long do you suspect this will take?

When do you think Phase 3 will start?

What worries me is, genetic markers were NOT on their timeline schedule back in 2010. Does this mean they are lagging behind more than 1 year as initially thought?

But genetic markers is something hey cna look for in parallel with the rest f the reseach and they donęt need it to sell the product? I would at least give the product a shot even if it was 50/50 if it worked(and it shuldnt cost full price if it doesn't work, you only need some injections to see how it if it works)

[Desmond84]

OK guys, time to start talking about release date:

As most of you heard on the presentation, Aderans has given up on reaching the "70% response rate" target and instead are looking for genetic markers that will indicate whether you're a responder or not.

So what does this mean for their release date?

How long do you suspect this will take?

When do you think Phase 3 will start?

What worries me is, genetic markers were NOT on their timeline schedule back in 2010. Does this mean they are lagging behind more than 1 year as initially thought?