Aderans

[rdawg]

You could also argue that something like HSC could bring these follicles back to life, essentially 'repairing' them.

Not to mention a future theoretical stem cell product down the line.

I dont think there is a limit to what hair loss products could do at any age, I think it's just a matter of the science and technology growing enough to do so. And I'd say we're getting closer to that point.

[ovoxo]

It is often assumed that hair that is lost in pattern balding somehow “dies” after a certain period of time, and is therefore gone for good, rendered incapable of re-generation. This assumption is also erroneously reinforced by certain doctors, and other hair specialists. The following case study published in a reputable peer reviewed journal, along with numerous anecdotal accounts we have received over the last 10 years convincingly refute this assumption. This particular study gives an account of a 73 year old man who had been completely bald since 28 re-growing a full head of hair at age 73 ( 45 years of slick baldness) after 6 years on oral Spironolactone, effectively shattering the assumption of “dead” hair follicles.


Acta Derm Venereol. 1990;70(4):342-3.

Reversal of andro-genetic alopecia in a male. A spironolactone effect?

Bou-Abboud CF, Nemec F, Toffel F.

Source

Department of Internal Medicine, University Medical Center of Southern Nevada, University of Nevada School of Medicine.


Abstract

This 73-year-old white male has been bald since the age of 28. He developed nonA-nonB-induced liver cirrhosis and had been treated with spironolactone for the last 6 years. For the last 3 months, his hair had started to regrow over the scalp. This might be related to the antiandrogenic effect of spironolactone.



My opinion is nobody really knows, these treatments might work, might not work. Time will tell and we can discuss all we want, but it won't change the outcome.

[hellouser]

I agree with youngsufferer. I have wasted soooooo much god damn time / energy / suffering on this shit. The reality is that its basically a lost cause for a while and as far as a real solid cure goes, thats a whilllle away were not very close at this point. It sucks more than anything, but it is the reality.

We are close, in fact we're already there. Just look into Dr. Roland Lausters work from Berlin. Whats holding us back is the whole legal crap.

[jgold]

I agree with youngsufferer. I have wasted soooooo much god damn time / energy / suffering on this shit. The reality is that its basically a lost cause for a while and as far as a real solid cure goes, thats a whilllle away were not very close at this point. It sucks more than anything, but it is the reality.

[clarence]

And let me tell you how impressive histogens pictures are haha. Histogen is trash

That is the reality of an NW5+.

But many people who are in the beginning stages of their hair loss and make some light effort to maintain what they have for 3 years, will wait for the full results over taking a hair transplant, if the Histogen works only half as well as their numbers tell you. We'll see soon enough, whether or not any pictures of theirs can compete with the numbers.

[youngsufferer]

You are being too pessimistic considering that both histogen and Aderians are conducting their clinical trials on NW3+s.

And let me tell you how impressive histogens pictures are haha. Histogen is trash, they're very open with their progress and have no impressive pictures at all. I really hope aderans has solved the puzzle, it would make sense that they're keeping quiet until FDA approved. I don't see that happening when we have scar tissue from years of inflammation mutilating the hair follicle. Regardless or not if the follicles or not die, that last study Desmond posted shows that they're too damaged to he functional even if we find a topical or injectable cure. This also explains why fin works so well for people who caught their hair loss early, and the regrowth they experience. Quit hearing what you want to hear. Go learn an instrument, get in the weight room, read some books and improve your life. It's going to be a while.

[StinkySmurf]

Hey Desmond, Can you provide a link to this info?

I can't find it.

Thanks!

Nevermind, I found the patent

http://www.aderansresearch.com/pdfs/US_Patent_7985537.pdf

[yeahyeahyeah]

If anything this should settle that there will never be a "cure"



When stemcells become a common thing to use in medicine we'll have a treatment, until then buy a piece or get a transplant. I've seen too many cases of guys my age(21) with hypogonadism because of fin. Your endocrine system is fragile and doesn't need to be messed with. Focus on improving your life because it's going to be a long bald road fellas.

You are being too pessimistic considering that both histogen and Aderians are conducting their clinical trials on NW3+s.

[StinkySmurf]

Genetic Test

With regards to genetic markers, one of the guys on our forum did some amazing investigative work and found out that they employed a geneticist to come up with specific genetic markers for their trial back in April 2011.

It's great news since it means they've been working on this genetic test for a while and Phase 3 should start sometimes in 2013

-- Fingers crossed of course

Hey Desmond, Can you provide a link to this info?

I can't find it.

Thanks!

[youngsufferer]

Hey guys,

Here's a very critical study I found that directly relates to how effective future treatments will be for us who have already started going through MPB:

Irreversibility of hair follicle changes after 30 months of Androgenetic Alopecia.

Konstantinova N, Korotkii N.G, Sharova N, Barhunova E, Gaevski D. Nioxin Research Inc, Atlanta, USA Moscow Medical University 2001

We studied horizontal and vertical biopsy from 15 caucasian 24-41 year old males diagnosed with bitemporal recession Androgenetic Alopecia (AA) for 1.5 –18 years (average 7.4 years). All 15 biopsies were stained with H&E, Van Gieson and with other collagen specific stainings.

1. Eleven pts with AA longer than 3 years had perifollicular fibrosis - collagen fibers were compact and formed a small scar-like formation around each anagen hair follicle(HF). Two patients - 33 year old with 18 month AA and 23 year old with 20 month AA did not have these hair follicle changes. Two 26-year-old patients with 30 and 36 month AA respectively were found to have some not so severe collagen fiber changes.

2. Infundibulum of HF dilatated 124-192 mm and most of them covered with keratinazed plug lacking normal hair shaft growth.

3. Decreased number of hair follicles 1.75-2,45 per sq. mm from 3.5-5 per sq. mm in control group.

4. None of anagen HF was situated in subcutaneous fat. We showed a correlation between length of the AA and severity/ thickness of perifollicular fibrosis.

The result of this study is that any treatment of AA is recommended to start earlier than 30 months from first signs of AA. This should prevent irreversible collagen changes associated with “fibrotic incapsulation” of most anagen HF in involved areas, which usually leads to loss of normal blood supply, innervation, and subsequent miniaturization and prevention of hair from normal cycling.


This is why it is vital for all of us to do everything we can to hang on to as much hair as possible until these treatments come out!

P.S. Artista thx for all your support brother. I wouldn't be doing so much research if it wasn't for you and everyone elses support!

Cheers

If anything this should settle that there will never be a "cure"



When stemcells become a common thing to use in medicine we'll have a treatment, until then buy a piece or get a transplant. I've seen too many cases of guys my age(21) with hypogonadism because of fin. Your endocrine system is fragile and doesn't need to be messed with. Focus on improving your life because it's going to be a long bald road fellas.

[yeahyeahyeah]

Yeah, it's definitely working! I'm approaching the 5th month now!

My hair shedding has returned to 2-3 years ago (a hair here or there) and my temples look a lot better!

The problem is when I drink coffee/alcohol, I get a bit of pain down there and my libido isn't where it was pre-fin. My erections are also a bit less full

How did you work out the dosages?

Trial and error?

[HARIRI]

You should get on RU58841 if Finasteride was working well for you.

Thanks for the advice but what the hell is RU58841? I never heard of it before!

But here I found it available for international shipping, I will give it a try along with Rogaine, which strength do you advice me to take if used with Rogaine? There is 1%, 2% and 5%!!! ...

http://www.mpbtreatments.com/#/shop/4563156995

[jgold]

i have no idea where i would buy that and i swear that stuff is sketchy too. god damn why cant they just come up with something legitimate.

[hellouser]

Desmond84. I agree with you. Before my 1st bad hair transplant. I restored all of my hairline and crown as I was NW2 by just using Propecia and Rogaine, but i developed in the 6th month weak erections and by the 9th month a partial ED although I reduced my dose to every other day. I was scared to hell and my partner felt so worried while I was so embarrassed. I had massive libido prior to that so when I stopped it, I had to wait one to two months for the sides to go. Right now Im just sticking with Rogaine and HairOmegaDHT which is Saw Palmetto plus other natural DHT blockers. God, how I wish Aderans and Histogen save our precious hair soon.

You should get on RU58841 if Finasteride was working well for you.

[HARIRI]

Desmond84. I agree with you. Before my 1st bad hair transplant. I restored all of my hairline and crown as I was NW2 by just using Propecia and Rogaine, but i developed in the 6th month weak erections and by the 9th month a partial ED although I reduced my dose to every other day. I was scared to hell and my partner felt so worried while I was so embarrassed. I had massive libido prior to that so when I stopped it, I had to wait one to two months for the sides to go. Right now Im just sticking with Rogaine and HairOmegaDHT which is Saw Palmetto plus other natural DHT blockers. God, how I wish Aderans and Histogen save our precious hair soon.