Aderans

[534623]

Here's a little summary

DHT is by far the main culprit, hence why Finasteride is so powerful at halting hairloss. Now:

1) To date, we have only found Androgen receptors on the dermal papillae & sebaceous glands of hair follicles.

• DP cells are the most important contributor to follicle growth and cycling.
  
• Sebaceous glands don't serve any roles in terms of growth, they are more of a supportive structure.

Hence, the reason why Aderans decided to use DP cells! Here's the link:

http://www.nature.com/jid/journal/v9.../5612065a.html

YOUR LINK DOESN'T WORK!

2) Here's the most AMAZING finding: back in late 90's it was found that "Dermal papillae extracted from occipital scalp hair follicles (donor area) lack Androgen receptors!

Here's the link:

http://onlinelibrary.wiley.com/doi/1...706.x/abstract

That's why I think at least in theory, DHT-resistance may be possible!

In another word, after DP transplantation, you will have TWO types of DP cells present in the root of the hair follicle (this is known as a "chimeric" follicle btw):

1) Original DP cells that are sensitive to DHT --> these are shrinking and refuse to provide the growth factors and signals necessary to promote hair growth.

2) Transplanted DP cells that lack Androgen receptors --> these cells would aggregate to form fully functional DP which support a healthy hair growth cycle!

Here's a little excerpt from one of the publications I found:

"The treatment area would be miniaturized follicles that are cosmetically insignificant, and the strategy would be to rejuvenate miniaturized follicles by the insertion of hair-inductive DP cells. Because the cellular target in androgenetic alopecia is the dermal papilla, providing the follicle with new, androgen-insensitive DP cells might reactivate the follicle to form a normal (terminal) hair. "

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884703/

Furthermore:

"Dermal Papillae cells remain the same throughout your whole life. They don't die or replicate." They simply move up and down the hair follicle during Anagen & Catagen Phase."

Thanks, Desmond - I didn't see your answer.

Anyway, the 1st posted link doesn't work - so I can't see who are the scientists who talk so much BS. The thingy with the sebaceous glands is correct. The "Tokyo-guys" confirmed this recently too.

[neversaynever]

"The cells of the DP are not only essential for hair follicle development and function, but are also a reservoir of cells with the potential to differentiate into a range of cell types that are of potential therapeutic importance"

http://jcs.biologists.org/content/124/8/1179.full

Maybe those cells unused by the follicles are destroyed by the immune system, but I guess theres a chance that they become different cell types.

[Desmond84]

I wouldn't worry too much about the ones that didn't make it!

Your body has immune cells that Police the intracellular environment. These include T cells, B cells, Macrophages, etc...

If they detect a cell that shouldn't be there, they either engulf it and cause phagocytosis (implode) or rupture the cell and cause apoptosis (explode).

Btw I just replied to ur email

[StinkySmurf]

That's a really good question and unfortunately only can be answered by the Aderans team. Their preclinical studies showed that extra DP cells do find their way into the hair follicle and aggregate with the original DP cells. So although there might be an upper limit, if the hair follicle has shrunk then more DP cells may be able to bind!

Haha! yes, I guess I wonder more about the cells that didn't bind to a follicle. Where do they end up and is that bad if you get too many floating around with nothing to do?

Hey I sent an email to your hotmail

[Desmond84]

Desmond, you've mentioned several times you think cultured DP cells don't increase or decrease in number so doesn't there have to be some type of upper limit on the number of cells you can have placed in your scalp like this and if we're worried about a remote chance of skin cancer does this increase it or is the cancer risk really unrelated to the dosage?

That's a really good question and unfortunately only can be answered by the Aderans team. Their preclinical studies showed that extra DP cells do find their way into the hair follicle and aggregate with the original DP cells. So although there might be an upper limit, if the hair follicle has shrunk then more DP cells may be able to bind!

With regards to cancer, that's something they've been monitoring for FDA approval since day 1. I am also a bit worried about that but can't really comment until I read their clinical data.

In theory though, it should be OK. I mean even though we don't have anybody offering DP transplantation at this point, we know of many hospitals using stem cell transplantations and that has proven safe with no risk of cancer!

[StinkySmurf]

Unlike with drugs or HT, where you increase risk the "more" of the procedure you use, with Aderans procedure you do not increase risk on successive treatments. And each time, you have the same odds of growing hair. With the same odds each time and zero increased risk, results should be compoundable.

I'm not sure about this theory... Only time will tell. But that's what I'm relying on now for Aderans. I think I'm right on this. But if this theory doesn't pan out, Aderans may become yet another colossal failure[/I]"

Desmond, you've mentioned several times you think cultured DP cells don't increase or decrease in number so doesn't there have to be some type of upper limit on the number of cells you can have placed in your scalp like this and if we're worried about a remote chance of skin cancer does this increase it or is the cancer risk really unrelated to the dosage?

[534623]

It took them years to do phase 2, how do you know they will be done with phase 3 so quickly?

The pic I posted, is based on Dr. Washenik's original timeline pic he presented in June 2010 in Tokyo - I have just prolonged accordingly his timeline pic.

Anyway, in Washenik's timeline pic, he calculated for every phase 2 and phase 3 trail (see the BLACK arrows Washenik made in the pic!) around 15-18 month.

here is Washenik's original timeline pic:

http://www.aderansresearch.com/presentation/

He is actually very similar to Nigam:
Washenik changes every 2 years his protocol, Nigam every 2 days.

[yeahyeahyeah]

It took them years to do phase 2, how do you know they will be done with phase 3 so quickly?

You best bet is histogen.

[Thinning87]

It took them years to do phase 2, how do you know they will be done with phase 3 so quickly?

[yeahyeahyeah]

According to this (Ji Gami CN trail) ...

... commercialization start would be anywhere in June-December 2015.

oh, and they WILL start to commercialize Gi Gami CN anywhere in 2015/2016.
To get FDA approval for GI Gami, THIS is defenitely not the problem ...

Where did you get the source for this?

[534623]

Here's the link to the last study:

http://clinicaltrials.gov/ct2/show/N...ji+gami&rank=2

According to this (Ji Gami CN trail) ...

... commercialization start would be anywhere in June-December 2015.

oh, and they WILL start to commercialize Gi Gami CN anywhere in 2015/2016.
To get FDA approval for GI Gami, THIS is definitely not the problem ...

[neversaynever]

So rogers theory is that injected cells are not grouping together, most of them are going to waste, it can work if its compoundable.

I wouldnt call that rogers theory, people have been saying that kinda stuff for a while now.

[Desmond84]

Hey, I'm new here.

I was looking around the web for news about an update from Aderans and came across this thread.

I couldn't figure it out looking through the posts...on what basis is it believed that Aderans will release their Phase 2 results in April?

Hey Merlin

Aderans has performed 11 Phase 2 trials. 9 of these have completed. 1 will finish in Feb 2013 and the last one will conclude in April 2013.

Here's the link to the last study:

http://clinicaltrials.gov/ct2/show/NCT01669746?term=ji+gami&rank=2

Estimated Enrollment: 40
Study Start Date: June 2012
Estimated Primary Completion Date: April 2013 (Final data collection date for primary outcome measure)

They will be presenting their final Phase 2 results at an investor's conference sometimes then. (Just like their 2010 presentation)

[534623]

Hey, I'm new here.

I was looking around the web for news about an update from Aderans and came across this thread.

I couldn't figure it out looking through the posts...

After around 900 replies in this thread?

That's because lots of guys on meds on such forums rather prefer to talk about things like a "massive twat" and/or a "massive bell end" - or whether or not "is it okay to masterbate 6 times a day". But these are just a few reasons why you couldn't figure out the answer you are looking for.

Anyway - here is what you're looking for ...

Dr. Ken Washenik’s recent presentation at the Stem Cells Meeting on the Mesa in California (October 29-31, 2012):

https://www.youtube.com/watch?v=l_JHbtXJ0a8

And here is a brief summary of his presentation:

http://www.utsandiego.com/news/2012/nov/03/making-case-for-stem-cell-treatment/

[pocketmerlin]

I know dude 2013 is the year we find out if there's a light at the end of this dark tunnel!

There are so many companies releasing major updates. We're talking:

- Histogen (Feb update re: final 12 month results)

- Aderans (April update re: Final Phase 2 results and Initiation of Phase 3)

- Replicel (November update re: Final 24 month results on Phase 1/2)

- Bimatoprost (Might be launched end of this year!)

- OC (June-July: Phase 2 trials start for baldness)

It's gonna be an epic year! I think the cutting edge section of BTT is gonna be going nuts

Hey, I'm new here.

I was looking around the web for news about an update from Aderans and came across this thread.

I couldn't figure it out looking through the posts...on what basis is it believed that Aderans will release their Phase 2 results in April?