Aderans

[Alf]

But why isn't aderans updating their website?

[Winston]

But let's not turn this thread into a debate FUT vs FUE/HST. If you want to go ahead with FUT and don't mind the scar and are happy with the result, then that's a good thing of course.

That's a good thought Arashi, this is an Aderans thread, lets try to keep it on track.

[Arashi]

FUT density is alot more than 80%.

Like said, skin will stretch thus reducing density. Besides you lose all the hairs in the donor area, while 80% grows back with HST. But let's not turn this thread into a debate FUT vs FUE/HST. If you want to go ahead with FUT and don't mind the scar and are happy with the result, then that's a good thing of course.

[clarence]

That's false. First of all, if you take out a strip of skin, that part of your skin has to be filled up. This means that:
1) Current skin streches a bit, which results in (slightly) lower density.
2) your hairline at the front and back of the head both recede (albeit slightly).

Furthermore, HSI yields 80% regrowth of the donor (at least, that's what they tell you at the clinic), so that preserves density quite well too. With FUT you (of course) don't have regrowth so you lose 80% more hair.

Ok, maybe I should have said one method preserves density and the other reduces that density. Like if one man buys coffee from the grocery store, and another man buys from a wholesale where they give him a discount, they first one saves money, and the other one loses that money.

FUT density is alot more than 80%. Yes, I am that vain.

[Arashi]

Because of effects on the donor area. It takes less than math skills to see that one method preserves density and the other reduces density. That's why, and I would rather have a FUT in a heartbeat, even if it yielded less and cost more than FUE.

That's false. First of all, if you take out a strip of skin, that part of your skin has to be filled up. This means that:
1) Current skin streches a bit, which results in (slightly) lower density.
2) your hairline at the front and back of the head both recede (albeit slightly).

Furthermore, HSI yields 80% regrowth of the donor (at least, that's what they tell you at the clinic), so that preserves density quite well too. With FUT you (of course) don't have regrowth so you lose 80% more hair.

[clarence]

Brother, we're all in the same boat and I didn't mean to offend anyone. I just meant I personally strongly feel that a HT isn't worth it when it leaves you with such a scar, but that's my personal opinion. I also meant that anyone choosing FUT over FUE/HSI nowadays because they still believe FUT yields better results (which was true in the past, but not anymore) is just misinformed, but of course I was speaking generally. You say in your specific situation FUT is superior and I'm sure you've come to that conclusion by doing good research, so I really wonder, why is that ?

Because of effects on the donor area. It takes less than math skills to see that one method preserves density and the other reduces density. That's why, and I would rather have a FUT in a heartbeat, even if it yielded less and cost more than FUE.

[Arashi]

Go ahead, just feel sorry all you like for a choice which is not one bit of your business, but don't you sit there behind your screen with your primitive hairstyle and offend my sanity because of my future choice in favor of FUT over the (in my case) inferior method, FUE. And I wonder, what could be more necessary for me than preserving the density of the donor area, despite the scar.

Brother, we're all in the same boat and I didn't mean to offend anyone. I just meant I personally strongly feel that a HT isn't worth it when it leaves you with such a scar, but that's my personal opinion. I also meant that anyone choosing FUT over FUE/HSI nowadays because they still believe FUT yields better results (which was true in the past, but not anymore) is just misinformed, but of course I was speaking generally. You say in your specific situation FUT is superior and I'm sure you've come to that conclusion by doing good research, so I really wonder, why is that ?

[clarence]

Totally agreed. Anybody going for FUT nowadays is crazy anyway. I feel sorry for everybody with such tremendously ugly scar on the back of their head, which is totally unnecessary anyway. I just uploaded a picture of my donor area shot at the HASCI clinic, right after 'surgery', barely any blood visible, see my album.

Go ahead, just feel sorry all you like for a choice which is not one bit of your business, but don't you sit there behind your screen with your primitive hairstyle and offend my sanity because of my future choice in favor of FUT over the (in my case) inferior method, FUE. And I wonder, what could be more necessary for me than preserving the density of the donor area, despite the scar.

[mjolnir]

I must admit, I've been playing with the idea of taking Fin myself, but after reading this article, every single hair on my head was convinced it was a VERY bad idea http://www.sciencedaily.com/releases...0807101330.htm

44% of the people with persistent sexual sides having suicidal thoughts ? Man, really, that's SO not worth it ...

Of course the other option is always a hair piece. Cost and upkeep would be a bit of a pain, but cosmetically they look pretty good now, and you're not actually messing with your body.

[Arashi]

Haha, fair enough. I'm on fin, though too late to save me from needing clever styling to hide my thin patch. That was a panicked reaction, I think - I had a lot of crap going on in my life, I wanted to at least try to control something. I haven't had any negative side effects, so I'm sticking with it, but if I had been more in my present state of mind at the time, I might have just said 'to hell with it', and shaved it all off.

I must admit, I've been playing with the idea of taking Fin myself, but after reading this article, every single hair on my head was convinced it was a VERY bad idea http://www.sciencedaily.com/releases...0807101330.htm

44% of the people with persistent sexual sides having suicidal thoughts ? Man, really, that's SO not worth it ...

[mjolnir]

Totally agreed. Anybody going for FUT nowadays is crazy anyway. I feel sorry for everybody with such tremendously ugly scar on the back of their head, which is totally unnecessary anyway. I just uploaded a picture of my donor area shot at the HASCI clinic, right after 'surgery', barely any blood visible, see my album.

Also, surgery is in my opinion WAY safer than taking medication that has known side effects as decreased libido, impotency and depression/suidical thoughts, like Finasteride. I'm vain but not THAT vain that I want to take poison like that ...

Haha, fair enough. I'm on fin, though too late to save me from needing clever styling to hide my thin patch. That was a panicked reaction, I think - I had a lot of crap going on in my life, I wanted to at least try to control something. I haven't had any negative side effects, so I'm sticking with it, but if I had been more in my present state of mind at the time, I might have just said 'to hell with it', and shaved it all off.

[Arashi]

I get what your saying but it really aint that bad, FUE anyway. When you use the word 'organs' that maks it sound more barbaric. But there is MUCH MORE invasive surgery than HT's.

Totally agreed. Anybody going for FUT nowadays is crazy anyway. I feel sorry for everybody with such tremendously ugly scar on the back of their head, which is totally unnecessary anyway. I just uploaded a picture of my donor area shot at the HASCI clinic, right after 'surgery', barely any blood visible, see my album.

Also, surgery is in my opinion WAY safer than taking medication that has known side effects as decreased libido, impotency and depression/suidical thoughts, like Finasteride. I'm vain but not THAT vain that I want to take poison like that ...

[Desmond84]

So, after seeing these promising results by Aderans in Phase 2, it is probably time to start talking about what is Ji Gami all about

Ji Gami is a culture of your:

a) Dermal papillae cells, and

b) Keratinocytes

that is extracted from the back of your scalp (1cmx1cm) and is multiplied in the laboratory to millions of cells. These cells are then injected into the balding areas to stimulate hair growth!

Now, the most important question is why are we only using these TWO cells? After all, the hair follicle is a complex organ which is made up of over 11 different types of cells (E.G. outer root sheath, inner root sheath, hair shaft, hair matrix, connective tissue sheath, dermal papilla, etc).

This can be best described by what is the role of these TWO cells:

1) DERMAL PAPILLAE (DP) CELLS

Dermal papillae are small, nipple-like extensions of the dermis into the epidermis. This is what gives you your fingerprints!

In your scalp, DP cells sit right below the hair follicle and contain blood vessels that nourish hair follicles with oxygen and nutrients.

DP cells are involved in the cycle of hair growth and shedding. Now, as most of you may know: The resting phase is known as telogen, the growth phase as anagen and the regression phase as catagen.

During catagen, the epithelial cells at the base of the follicle undergo apoptosis, but the DP remains intact and is pulled or migrates upwards, until it comes to rest next to the stem cells of the hair follicle bulge. This situation persists during telogen. In anagen, cells at the base of the follicle start to proliferate, which results in downward growth of the follicle and envelopment of the DP.

DP cells themselves are thought to not divide. However, the number of cells in the DP increases during anagen, possibly as a result of replenishment from neighbouring cells of the dermal sheath.

Now, here’s some important facts about Dermal Papillae cells:

I. Androgen receptors have only been found in dermal papillae cells of hair follicles. In vitro tests have shown that embedding DP cells (cultivated from androgen sensitive areas) in testosterone significantly shrinks their size, thereby reducing the amount of blood supply to the hair follicle and the launch of an inflammatory caspase response!

II. DP cells remain substantially unaltered (except in size) throughout life. They are formed on day 14 of embryo development and remain the same until you die! This means Aderans treatment will have a PERMANENT effect!

2) KERATINOCYTES

Keratinocytes form the hair itself. Studies in late 90’s found that DP cells can be easily cultured if they are grown on top of Keratinocytes. To my knowledge, that is the only reason Aderans is using these cells. (However, I could be wrong)

[UK_]

If those are the norwoods they are treating then I am more than happy - because Aderans know this treatment needs to be something that can AID their existing hair transplants - theyve said this all along - you will still need to have a HT but the injections will give you natural density.

[Pate]

Yeah definitely some minor terminal hair growth on slick bald scalp. And now that that scalp isn't slick bald any more, the blood vessels and fat later are building up again, would this area respond even better to a repeat application after 6 months?

It's not beyond the grounds of possibility. Could Aderans actually get more effective with subsequent treatments?

There would be a limit to the number of biopsies you can have, so hopefully they can keep culturing the original cells for subsequent injections.