Aderans

[JJJJrS]

Call me cynical but this process always seems to repeat itself with these new technologies.

First, the treatment is said to create totally new follicles. When that doesn't prove to be the case, the claim then becomes that it rejuvenates weakened/miniaturized follicles. Finally, they say it prevents the existing follicles from miniaturization. With each claim it becomes more and more difficult to prove.

Don't get me wrong, a side-effect free treatment that prevents the balding process or even slows it down would be a huge deal. All the younger patients in the early stages of baldness would effectively be cured, while those at a more advanced stage would be much more viable candidates for existing surgical treatments. Unfortunately, I'm very skeptical until I see more tangible evidence.

[yeahyeahyeah]

1) not everyone is already a NW7
2) not everyone needs to get back to a NW0 to be happy
3) cool science is still cool, regardless of whether it benefits you personally
4) this could be used in conjunction with other treatments
5) it doesn't have a zero success rate because they have pictures of it working. just not quite as well as you'd like.

6) Low norwoods - NW3s can get back down a norwood level or 2 with this.

HT surgeons in turn will be less 'conservative' with their approach - only reason why they currently are, is in case the hairloss progresses.

[Desmond84]

So what exactly is he saying in this scene (10:20 >>>)?

Seems the stuff just works (if at all) for “still not that much AGA-affected hair follicles”.
But in almost slick bald areas = game over (= point of no return) = no rejuvenation of "too dead hair follicles". Sounds logical – is logical.

Yeah I think if you have a small bald spot, you can kind of fix it with hair transplants and Aderans will permanently maintain the hair you have (kind of like Propecia)

[Desmond84]

what's the point in making follicles resistant to DHT if you have no hair? Do you really think anyone besides of a couple desperate people from this forum have any interest in that? As I said before, cell based treatments will have a ZERO SUCCESS RATE. Just forget about it. Your only real hope in the next 5 years is Histogen. That's it.

Success rate will be dependent on stage of hairloss and your genetics!

Don't forget the possibility of using Histogen to kick start the follicles and then Aderans to maintain these follicles in the near future!

I just hope Aderans will be available soon! I hate the waiting game

P.S. The 60% response rate was regarding hair regrowth! I wonder how many % maintained their hair?

[mjolnir]

what's the point in making follicles resistant to DHT if you have no hair? Do you really think anyone besides of a couple desperate people from this forum have any interest in that? As I said before, cell based treatments will have a ZERO SUCCESS RATE. Just forget about it. Your only real hope in the next 5 years is Histogen. That's it.

1) not everyone is already a NW7
2) not everyone needs to get back to a NW0 to be happy
3) cool science is still cool, regardless of whether it benefits you personally
4) this could be used in conjunction with other treatments
5) it doesn't have a zero success rate because they have pictures of it working. just not quite as well as you'd like.

[ihavebeenchosenithasbegun]

what's the point in making follicles resistant to DHT if you have no hair? Do you really think anyone besides of a couple desperate people from this forum have any interest in that? As I said before, cell based treatments will have a ZERO SUCCESS RATE. Just forget about it. Your only real hope in the next 5 years is Histogen. That's it.

Very interested.

[534623]

https://www.youtube.com/watch?v=l_JHbtXJ0a8

So what exactly is he saying in this scene (10:20 >>>)?

Seems the stuff just works (if at all) for “still not that much AGA-affected hair follicles”.
But in almost slick bald areas = game over (= point of no return) = no rejuvenation of "too dead hair follicles". Sounds logical – is logical.

[2020]

what's the point in making follicles resistant to DHT if you have no hair? Do you really think anyone besides of a couple desperate people from this forum have any interest in that? As I said before, cell based treatments will have a ZERO SUCCESS RATE. Just forget about it. Your only real hope in the next 5 years is Histogen. That's it.

[Joker]

Great attitude Desmond and very true!

[ihavebeenchosenithasbegun]

First of all, thanks Joker for being such a great journalist! No new info will ever get past you brother

TBH, this 15 minute presentation was groundbreaking in my opinion! We have finally found a way to make follicles resistant to DHT without having systemic side effects the way Propecia does. Welcome to 21st century ladies and gentlemen

On a side note, the key to getting a great response was to still have semi-miniaturised follicles rather than bald spots! So, it is vital to remain on DHT blockers for as long as possible to prevent any further miniaturisation until we get to Aderans!

Also, sadly, Washenik had no intention to announce that Phase 2 trials are almost over meaning there may be more Phase 2 trials to come! Oh well, it's out of our hands I suppose! Now, we just have to be patient

If it can do that, it's an absolute win for me.

[Desmond84]

Three cheers to Joker

https://www.youtube.com/watch?v=l_JHbtXJ0a8

Aderans presentation from Stem Cell Meeting on the Mesa.

Like always, very disappointing results. Sorry, guys.

Let's just hope that Dr. Cole is actually able to regenerate donor using ACell... looks like that's our only hope at this point.

First of all, thanks Joker for being such a great journalist! No new info will ever get past you brother

TBH, this 15 minute presentation was groundbreaking in my opinion! We have finally found a way to make follicles resistant to DHT without having systemic side effects the way Propecia does. Welcome to 21st century ladies and gentlemen

On a side note, the key to getting a great response was to still have semi-miniaturised follicles rather than bald spots! So, it is vital to remain on DHT blockers for as long as possible to prevent any further miniaturisation until we get to Aderans!

Also, sadly, Washenik had no intention to announce that Phase 2 trials are almost over meaning there may be more Phase 2 trials to come! Oh well, it's out of our hands I suppose! Now, we just have to be patient

[mjolnir]

Looks like a visible improvement. Technology takes time, and a weak proof of concept is a heck of a lot better than nothing at all. The takeaway here is that these regenerative techniques work for growing hair. Now it's just a question of seeing how far it can be taken.

That said, I'm still hoping for Histogen. Aderans still requires a biopsy to collect your cells, and I don't think I'd be comfortable with a procedure that's going to leave permanent scaring.

[Joker]

But before I get too negative, I should mention that if this treatment is compoundable (and Doc Washenik says it should be) it could actually lead to some pretty good outcomes, especially when combined with transplants.

Also, if the new hairs which are created are androgen resistant forever, that could be really helpful.

So it's not all bad news. It's not shocking regrowth, but with compoundability and androgen resistance it could actually be a great treatment potentially.

PS, did anyone notice that the little gun thing said Phase 3 underneath? I guess that's a good sign.

[Joker]

https://www.youtube.com/watch?v=l_JHbtXJ0a8

Aderans presentation from Stem Cell Meeting on the Mesa.

Like always, very disappointing results. Sorry, guys.

Let's just hope that Dr. Cole is actually able to regenerate donor using ACell... looks like that's our only hope at this point.

[Joker]

Thanks, Desmond. I do my best! Frankly, I wish I didn't have to... but at this point, all we can go on is bits and pieces of random information. Any word from Spencer on his potential interview w/ Ken Washenik?