CB-03-01 - new antiandrogenic

[burtandernie]

CB doesnt cause any major known sides because its a receptor antagonist not a systemic enzyme inhibitor. Its an ideal AA it competes with T and DHT while in theory rendered harmless once it hits blood. Its theory because its not fully studied so its all guessing as usual. We wont know for years anyway but phase 2 ended in november this year. It could end up having strong sides and it might not. No point in guessing but I think its chances are good its safer than what exists now and hopefully as effective

[ShookOnes]

In theory this will have minimal sides especially compared to current stuff. It needs to be a reasonable cost, strong enough, and related to that a good vehicle so it gets where it needs to. This could end up safe enough to just take long before you ever lose any hair so prevention will be much easier since lots of people delay doing anything because of the risk associated with a life long internal drug.
I hope its strong though because you need some mighty powerful AA action to get good results like castration levels to actually prevent MPB. Hopefully it stops a lot of T as well as DHT.

You want sides worse than fin it seems

[burtandernie]

any kind of DUT or FIN replacement is welcome in my eyes, I dont get any major sides from DUT but it's the kind of thing you dont want to be taking your entire life(it does mess with my libido the day after, but nothing major after that).

We need something safe with the same if not better maintenance affects that DUT has.

I agree. My hope is with CB since its actively being worked on, but many others have come and gone. There was RU, ascj 9, and others. I mean Ascj 9 was similar to CB and it has sat there without an owner for like 10 years. Could have been out by now if it worked. Companies just dont see the money or benefit I guess.

[rdawg]

any kind of DUT or FIN replacement is welcome in my eyes, I dont get any major sides from DUT but it's the kind of thing you dont want to be taking your entire life(it does mess with my libido the day after, but nothing major after that).

We need something safe with the same if not better maintenance affects that DUT has.

[burtandernie]

In theory this will have minimal sides especially compared to current stuff. It needs to be a reasonable cost, strong enough, and related to that a good vehicle so it gets where it needs to. This could end up safe enough to just take long before you ever lose any hair so prevention will be much easier since lots of people delay doing anything because of the risk associated with a life long internal drug.
I hope its strong though because you need some mighty powerful AA action to get good results like castration levels to actually prevent MPB. Hopefully it stops a lot of T as well as DHT.

[ShookOnes]

will this anti androgenic have less sides then dutas? Iḿ developing puffy nippels, I really can drop my dutas yet.

its topical, so yes.

[givemehairs]

will this anti androgenic have less sides then dutas? Iḿ developing puffy nippels, I really can drop my dutas yet.

[burtandernie]

Doesnt CB phase 2 trials finish this coming month november? Seeing some results with a good topical vehicle I wonder how well it ends up working. There is plenty of speculation out there that its too weak, or whatever but results are bigger than words

[chongmet]

Nobody has any method of verifying the results or lack thereof. Everything everyone has done so far has basically been just a shot in the dark. I'm not even fully convinced that the CB people are buying either from Iron Dragon, Kane or elsewhere is 100% real, I have my doubts.

So.We are in late 2015. Have you tried CB anyhow? I really want to give it a shot, but for a proper period of time, Like 1 year. Have you heard about someone who used it? Is the vehicle really an issue?

[lifelonglearning]

Is their anyone currently using CB? If so can you state your source , vehicle and experience using it

[inbrugge]

i see what you mean about the cosmo trial but ionto in general, you don't think it has a lot of potential? you can guarantee direct delivery so you can use to much lower amounts of application and dosage meaning very little side effects. imagine topical dut with no side effects.

[lilpauly]

Ah okay so its this recent trial they were doing they said that.

Yes man they conclude in summer

[burtandernie]

hi man its in the clincal trials. http://clinicaltrials.gov/ct2/show/NCT02279823


i talked to some1 from cosmo last year and he mentioned it was going to be a gel.

Ah okay so its this recent trial they were doing they said that.

[lilpauly]

that study is flawed . that study was from 3 years ago and it went no where .

[lilpauly]

look at this study


Background

Latanoprost is a prostaglandin analogue used to treat glaucoma. It can cause adverse effects, such as iridial and periocular hyperpigmentation, and eyelash changes including pigmentation and increased thickness, length, and number. Latanoprost has been used to treat eyelash alopecia, but knowledge on its effects on human scalp hair growth is not available.

Objective

The primary objectives were to assess the efficacy of latanoprost on hair growth and pigmentation. The secondary objectives were to assess the effect on scalp pigmentation; investigate the treatment duration needed to affect hair growth, hair pigmentation, and scalp pigmentation; and assess safety of latanoprost.

Methods

Sixteen men with mild androgenetic alopecia (Hamilton II-III) were included. Latanoprost 0.1% and placebo were applied daily for 24 weeks on two minizones on the scalp. Measurements on hair growth, density, diameter, pigmentation, and anagen/telogen ratio were performed throughout the study.

Results

At 24 weeks, an increased hair density on the latanoprost-treated site was observed compared with baseline (n = 16, P < .001) and placebo-treated site (P = .0004).

Limitations

Only young men with mild androgenetic alopecia were included. The results may not be applicable to other patient groups. Choice of investigational site may have affected the results.

Conclusions

Latanoprost significantly increased hair density (terminal and vellus hairs) at 24 weeks compared with baseline and the placebo-treated area. Latanoprost could be useful in stimulating hair follicle activity and treating hair loss.

*********With 6 months of 0.1% latanoprost in a 5/3/2 ethanol/pg/water vehicle on 16 living, breathing AGA men they achieved a 22% density increase********