CB-03-01 - new antiandrogenic

[lilpauly]

look at this study


Background

Latanoprost is a prostaglandin analogue used to treat glaucoma. It can cause adverse effects, such as iridial and periocular hyperpigmentation, and eyelash changes including pigmentation and increased thickness, length, and number. Latanoprost has been used to treat eyelash alopecia, but knowledge on its effects on human scalp hair growth is not available.

Objective

The primary objectives were to assess the efficacy of latanoprost on hair growth and pigmentation. The secondary objectives were to assess the effect on scalp pigmentation; investigate the treatment duration needed to affect hair growth, hair pigmentation, and scalp pigmentation; and assess safety of latanoprost.

Methods

Sixteen men with mild androgenetic alopecia (Hamilton II-III) were included. Latanoprost 0.1% and placebo were applied daily for 24 weeks on two minizones on the scalp. Measurements on hair growth, density, diameter, pigmentation, and anagen/telogen ratio were performed throughout the study.

Results

At 24 weeks, an increased hair density on the latanoprost-treated site was observed compared with baseline (n = 16, P < .001) and placebo-treated site (P = .0004).

Limitations

Only young men with mild androgenetic alopecia were included. The results may not be applicable to other patient groups. Choice of investigational site may have affected the results.

Conclusions

Latanoprost significantly increased hair density (terminal and vellus hairs) at 24 weeks compared with baseline and the placebo-treated area. Latanoprost could be useful in stimulating hair follicle activity and treating hair loss.

[lilpauly]

lilpauly, can we assume cb gives great results with no side effects if it is used the same way it was used in cosmo's first set-up with iontophoresis (i think it was once a week application! no?)

why not replicate that set-up? iontophoresis devicss aren't that expensive (200$-500$) and at one application per week with those results it'll definitely be worth it (and cb will be affordable at that low amount of usage).

in fact, iontophoresis can also improve other existing applications like minox, ru, dut, fin, etc.

so why don't we find a way to replicate cosmo's first application? do you know anyone who can help us achieve this? maybe kane has some knowledge about this?

to be honest with bro I'm not that convinced with the ionto . I'm not even that convinced that much with the first trail they did . What do all these trials have in common ? They all grow trendnous amount of hair !!! It's to get investors .

[inbrugge]

lilpauly, can we assume cb gives great results with no side effects if it is used the same way it was used in cosmo's first set-up with iontophoresis (i think it was once a week application! no?)

why not replicate that set-up? iontophoresis devicss aren't that expensive (200$-500$) and at one application per week with those results it'll definitely be worth it (and cb will be affordable at that low amount of usage).

in fact, iontophoresis can also improve other existing applications like minox, ru, dut, fin, etc.

so why don't we find a way to replicate cosmo's first application? do you know anyone who can help us achieve this? maybe kane has some knowledge about this?

[lilpauly]

Just out of curiosity when you say CB must be used 2x a day 5% where do you come with those numbers and in what vehicle?

hi man its in the clincal trials. http://clinicaltrials.gov/ct2/show/NCT02279823


i talked to some1 from cosmo last year and he mentioned it was going to be a gel.

[burtandernie]

Just out of curiosity when you say CB must be used 2x a day 5% where do you come with those numbers and in what vehicle?

[lilpauly]

has anyone tried iron dragon 1% cb and I mean twice a day usage for at least six months to a year?

cb must be used 2x day 5%

[lilpauly]

I'm not using it. I sorta threw in the towel. Plus all the results I've ever seen of CB are dubious.

this!

[lilpauly]

That, or perhaps the CB everyone's been using is fake. I don't have the answers.

yes results have been pretty shitty !

[Pelopeleon]

There was not a report at the end of each month about cosmo research and finances? When will it be posted there?

[doke]

So no answer to my question so why are you guys not trying it then as without using for the length of time I have said its not worth keep going on about it.
If iron dragon have this topical I know its 1% but you could use more say 4mls a day or trial your own dose theres nothing to lose exceipt the cost but if it worked it would be worth it.
It I think would have to be used with another regrowth agent such as minoxidil as in when using ru.

[lifelonglearning]

What the size and weight of the molecule?

[burtandernie]

Cosmo has more than enough funds...so as long as THEY decide to push CB for hair loss, funding will not be an issue!

Yeah this is my biggest worry now along with just the amount of time until we finally see it.

[doke]

has anyone tried iron dragon 1% cb and I mean twice a day usage for at least six months to a year?

[Duke]

Cosmo has more than enough funds...so as long as THEY decide to push CB for hair loss, funding will not be an issue!

[Haircure]

Ah okay just wondered. Thats my biggest worry about CB is that it wont get funded and seen through to the finish line. There are lots of good things that never made it and its just never the same trying to make it yourself these things are just too hard to do your on own

I doubt funding will be an issue since Cosmo pharmaceuticals seems to be doing very well, especially in their stock, which has increased dramatically over the past 5 years or so. And it's most likely the same for other treatments, because if they worked, then there would definitely be investors involved. So most likely treatments that have been postponed or canceled have likely been done so due to issues with effectiveness.