Where are the phase IIb results for Bimatoprost?

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  • burtandernie
    replied
    Is BIM going to provide some protective effect against androgens too? I thought someone mentioned it might just be needed a few times a week instead of everyday. I guess that includes the huge assumption that it works or ever comes out.

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  • Tomtom21
    replied
    This is my speculation and yes it is a speculation so take it as you'd like. 2014 tell me your opinion. I find it hard to believe it is dead when they have bim for hair loss listed as one of there products in late stage development for aesthetics in their presentation. Further review shows that they made mention of kythera's product aga for R&D. So at that alone i dont feel that bim is dead in the water. Further speculation and again i could completely out of my element here as i have linited knowledge on patents, but wasnt part of the issue with bim patent rights? Whereas, other companies would be capable of producing it? If thats the case maybe they intend to make a dual topical of seti + bim and patent it together as their acquisition of kythera grants them exclusive rights to anti pgd2. Of course they would still need to prove efficacy of seti which for us would delay development of a product. However, im sure i read on this thread before a quote from cots saying a topical of pgd2 blocker would be ideal and that in conjunction with bim would be the "foot off the brake and flooring the gas." Again guys this is all speculation and quite optimistic as we are all in the same boat here. Personally i have my faith in samumed as all these stem cell and regeneration studies point to the wnt pathway. Cheers fellas hopefully good news is on the horizon! Hang in there!

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  • It's2014ComeOnAlready
    replied
    Originally posted by maver1ck
    I love the optimism. I dont necessarily think its dead in the water either but to play devils advocate with the whole "investor relation" point for a second. Why would a member of the company straight up tell an investor that a product has failed, especially a product that people are counting on to become a reality. I'm not saying that she was just placating him but its not out of the realm of possibility.
    I've thought the same thing, but I think that investor relations person was honest and doing a good job. He called two days earlier and she refused to give any information, but promised to dig deeper. Two days later, she called and explained everything which I've written about. She didn't have to do anything, but she went out of her way to find out, then call him back. Clearly, he was very interested in the scalp product, and could've told him "I wouldn't get your hopes up on this particular product."

    Just to point out, what I'm saying that it is fishy, that after all this time, they still haven't released results or said this particular application has failed. Especially when there are two other uses for this product that do work. Meanwhile, you have people on here who've been to dermatologists offices that claim to work closely with Allergan and say they are planning to release a product based on bim for hair soon, like the summer. Then there's also Spencer Kobren who's said he'd been hearing that the last trial did really well. He was confident enough to say, "It's going to be great that we're going to have another weapon in our arsenal."

    My hope is waning. But like I said, if nothing is announced between now and January, it is dead. Right now it's just a waiting game.

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  • maver1ck
    replied
    Originally posted by It's2014ComeOnAlready
    Still no evidence that bim has failed. Technically, the last trial ended in September, because that's when the primary outcome measure was taken. It has been a very long time, and still, they haven't release results to investors. There is a difference between releasing results to the public and releasing them to investors. Something else is going on here.

    When BiqqieSmalls (a shareholder) called them a few months ago, he was told that the results haven't been released yet because of the "complexity of bimatoprost." Also, that they would be released "in a few months." A "few" is a pretty loose term, but it could mean 3-5 months. It's been a very long time, and they could have said it failed.

    Investor relations could have dissuaded him and said it didn't do well, without giving any actual details or figures. Instead, they were like a stone wall. There is no reason for this company to be afraid of poor results from this drug for the scalp, because it clearly works for eyelashes and glaucoma. Therefore it's not a total failure. No loss to say it doesn't work for the scalp. But they haven't said that, and they haven't said that for nearly a year.

    I have said all along that they do not want the word getting out that it works, because labs, individuals, and maybe other reputable companies would go ahead and purchase bimatoprost in bulk and formulate it themselves. I've also pointed out that in the past, when they were developing latisse, many people tried to get their hands on it (as noted by David Pyott, former CEO of Allergan). This is MPB, not eyelashes, the demand would be greater. The main deterrent is that bim powder is very expensive, and nobody knows if it works. By not letting anyone know, they have the power. They will not release results until they have a product ready to market or sell.

    Bim is not dead, but if nothing is announced between now and January, then it is dead imo.
    I love the optimism. I dont necessarily think its dead in the water either but to play devils advocate with the whole "investor relation" point for a second. Why would a member of the company straight up tell an investor that a product has failed, especially a product that people are counting on to become a reality. I'm not saying that she was just placating him but its not out of the realm of possibility.

    Leave a comment:


  • allTheGoodNamesAreTaken
    replied
    Originally posted by Farkhairloss
    This waiting is bullsh t. Do we know what percent they are or were trialling for scalp hair? Is this Kane who a lot of guys are getting there RU off capable of making a high contrate of Bim for a group buy at a reasonable price? Or if its that expensive to make we could chip in and get a nominated member to trial it?
    Recently posted a thread asking the same thing, 300 people have read it, no one bothered to reply.

    Leave a comment:


  • Farkhairloss
    replied
    This waiting is bullsh t. Do we know what percent they are or were trialling for scalp hair? Is this Kane who a lot of guys are getting there RU off capable of making a high contrate of Bim for a group buy at a reasonable price? Or if its that expensive to make we could chip in and get a nominated member to trial it?

    Leave a comment:


  • breakbot
    replied
    Originally posted by It's2014ComeOnAlready
    Still no evidence that bim has failed. Technically, the last trial ended in September, because that's when the primary outcome measure was taken. It has been a very long time, and still, they haven't release results to investors. There is a difference between releasing results to the public and releasing them to investors. Something else is going on here.

    When BiqqieSmalls (a shareholder) called them a few months ago, he was told that the results haven't been released yet because of the "complexity of bimatoprost." Also, that they would be released "in a few months." A "few" is a pretty loose term, but it could mean 3-5 months. It's been a very long time, and they could have said it failed.

    Investor relations could have dissuaded him and said it didn't do well, without giving any actual details or figures. Instead, they were like a stone wall. There is no reason for this company to be afraid of poor results from this drug for the scalp, because it clearly works for eyelashes and glaucoma. Therefore it's not a total failure. No loss to say it doesn't work for the scalp. But they haven't said that, and they haven't said that for nearly a year.

    I have said all along that they do not want the word getting out that it works, because labs, individuals, and maybe other reputable companies would go ahead and purchase bimatoprost in bulk and formulate it themselves. I've also pointed out that in the past, when they were developing latisse, many people tried to get their hands on it (as noted by David Pyott, former CEO of Allergan). This is MPB, not eyelashes, the demand would be greater. The main deterrent is that bim powder is very expensive, and nobody knows if it works. By not letting anyone know, they have the power. They will not release results until they have a product ready to market or sell.

    Bim is not dead, but if nothing is announced between now and January, then it is dead imo.
    Bla bla...Why did they mention then the other drugs that will enter phase 3? For example the treatment of glaukoma.Wouldn't then those people try to buy from another sources this stuff to treat their disease? What makes hairloss unique?
    You overrate hairloss market.If you do your homework as you say then you will see that the most companies don't release results of failed projects.

    Leave a comment:


  • champpy
    replied
    2014comeonalready, i love your optimism man. Listening to you keeps a small glimmer of hope alive. But man your theory is almost as complex as bimatoprosts "complexities". Really we are basing all hope on two second hand accounts (one from an unnamed investment spokesperson and the other from a guys whos derm dr supposedly works close to allergen.) Not saying they are, but both stories could be false. Oh and even spencer on his show said he heard positive things regarding bim, but gives nothing more than that. Then the fact that this drugs results are being hidden better than than the existence of aliens and ufos.
    Like fox mulder would say, i want to believe. But man, sometimes the simplest answer is the right one. And now the simplest answer is they have nothing to report because it just didnt work.
    i hope im wrong. I pray youre right. But i just dont think bim is the answer. With the availability of bim nowadays, somebody out there with abundant cashflow should have used enough to have results. But still we never hear stories of anyone growing scalp hair on this stuff. Not one person.
    Theres just no evidence. Just speculation. Im ready to forget bim and move on to the next false hope

    Leave a comment:


  • It's2014ComeOnAlready
    replied
    Originally posted by champpy
    Follicept. Failed.
    Bim scalp. Failed
    what potential treatment we are hoping for will be the next one to enter this treatment graveyard?
    This is so discouraging. Even if they said yeah its coming and it works, but will be a year or more away, i would be elated. I just want hope. All we get is false hope and then we are smacked back to reality each time.

    Follicept and bim were the only things we might possibly get our hands on in 2015. Now those seem dead and buried.

    Does anyone know where is a reputable place to buy pure bim powder. Im tempted to just buy the stuff myself and do a test of 1-2%, even if its expensive as hell. Im tired of the waiting game. None of us are getting any younger.
    Still no evidence that bim has failed. Technically, the last trial ended in September, because that's when the primary outcome measure was taken. It has been a very long time, and still, they haven't release results to investors. There is a difference between releasing results to the public and releasing them to investors. Something else is going on here.

    When BiqqieSmalls (a shareholder) called them a few months ago, he was told that the results haven't been released yet because of the "complexity of bimatoprost." Also, that they would be released "in a few months." A "few" is a pretty loose term, but it could mean 3-5 months. It's been a very long time, and they could have said it failed.

    Investor relations could have dissuaded him and said it didn't do well, without giving any actual details or figures. Instead, they were like a stone wall. There is no reason for this company to be afraid of poor results from this drug for the scalp, because it clearly works for eyelashes and glaucoma. Therefore it's not a total failure. No loss to say it doesn't work for the scalp. But they haven't said that, and they haven't said that for nearly a year.

    I have said all along that they do not want the word getting out that it works, because labs, individuals, and maybe other reputable companies would go ahead and purchase bimatoprost in bulk and formulate it themselves. I've also pointed out that in the past, when they were developing latisse, many people tried to get their hands on it (as noted by David Pyott, former CEO of Allergan). This is MPB, not eyelashes, the demand would be greater. The main deterrent is that bim powder is very expensive, and nobody knows if it works. By not letting anyone know, they have the power. They will not release results until they have a product ready to market or sell.

    Bim is not dead, but if nothing is announced between now and January, then it is dead imo.

    Leave a comment:


  • champpy
    replied
    Follicept. Failed.
    Bim scalp. Failed
    what potential treatment we are hoping for will be the next one to enter this treatment graveyard?
    This is so discouraging. Even if they said yeah its coming and it works, but will be a year or more away, i would be elated. I just want hope. All we get is false hope and then we are smacked back to reality each time.

    Follicept and bim were the only things we might possibly get our hands on in 2015. Now those seem dead and buried.

    Does anyone know where is a reputable place to buy pure bim powder. Im tempted to just buy the stuff myself and do a test of 1-2%, even if its expensive as hell. Im tired of the waiting game. None of us are getting any younger.

    Leave a comment:


  • Parsia
    replied
    Originally posted by dus
    There is ZERO speculation in my post. I don't know what to make of BIM and will just wait for an official statement.
    Ok then , Guys lets concentrate on something we have out there ! I believe the treatment is not only Two damn fda approved ! Remember
    took centuries for human to discover U.S , So there are many potents things out there for treatment baldness , we just have find our own way ! I won't follow this anymore.

    Leave a comment:


  • rdawg
    replied
    Originally posted by maver1ck
    Allergan released their q2 report and there is only 1 mention of BIM and its that its starting phase 3 as a treatment for glaucoma
    2nd form of treatment BIM has gone to phase III on(first was eyelash growth which got approved).

    Safety doesn't seem to be an issue here, something is up behind the scenes with the hairloss trial, patent issues maybe?

    All signs point to this drug being safe and at least in theory effective, so what's the hold up!

    Leave a comment:


  • dus
    replied
    Originally posted by maver1ck
    If BIM was so promising as everyone had been led to believe then why not mention anything to the investors if it was successful?
    There is ZERO speculation in my post. I don't know what to make of BIM and will just wait for an official statement.

    Leave a comment:


  • maver1ck
    replied
    Originally posted by dus
    If BIM for hair was scrapped they would tell investors. Everybody take a chill pill. The waiting game continues.
    If BIM was so promising as everyone had been led to believe then why not mention anything to the investors if it was successful?

    Leave a comment:


  • dus
    replied
    If BIM for hair was scrapped they would tell investors. Everybody take a chill pill. The waiting game continues.

    Leave a comment:

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