Where are the phase IIb results for Bimatoprost?

[It's2014ComeOnAlready]

Anything else work? Lol.

NO.

That was a rhetorical question

[StayThick]

Well, that's why I finished with "that's my take." If it failed, I understand why there wouldn't be a press-release, but why not make the results public?

This is getting ridiculous, does nothing but fin and dut work for hair loss?

Anything else work? Lol.

NO.

[It's2014ComeOnAlready]

The bottom line is that we still have no idea as to the efficacy of bimatoprost for hair growth. If things were great, Actavis is likely to have swiftly moved forward with Phase 3 as it has done with several other of its properties. Speculation by 2014 that Actavis is staying quiet BECAUSE bimatoprost is a known success is almost assuredly wrong. Companies do not offer press releases for failed products. They stay quiet until they announce their pipeline on a going forward basis (something Actavis said it plans to do during its next R&D day), and the products that don't make the cut are silently dropped. Thus, silence does not = success.

Now, I'm not saying bimatoprost has failed. I really have no idea. It may or may not be one of the many clinical programs Actavis hopes to push forward in the relatively near term. But we know that it is not currently in Phase 3, and we also know that it could be a long time before we are made aware of success/failure. All I want to say is that the business analysis (not necessarily the scientific analysis, which I think is generally sound) taking place on this forum is too highly speculative, in my opinion. At this point, all we can really do is wait and hope that Actavis realizes the promise of bimatoprost as a clinical and commercial opportunity.

Well, that's why I finished with "that's my take." If it failed, I understand why there wouldn't be a press-release, but why not make the results public?

This is getting ridiculous, does nothing but fin and dut work for hair loss?

[Joker]

Just gonna add some more facts to the discussion here.

This morning, Actavis had their Q1 2015 earnings call. The company is doing extraordinarily well.

The bad news is that they mentioned the clinical progress of and announced new clinical trials for several key Allergan products (DARPin, bimatoprost SR, etc.) without mentioning anything about bimatoprost for hair growth. No analysts even inquired about bimatoprost for hair growth (suggesting that this may not be a major priority outside of our community).

The company also mentioned, however, that they are still in the process of working through their pipeline and making decisions as to which programs will move forward and which programs will not. They are planning on moving forward with about 70 products, 50 of which are already late-stage. (source: http://actavis.com/news/news/thomson...nce-in-first-q)

The bottom line is that we still have no idea as to the efficacy of bimatoprost for hair growth. If things were great, Actavis is likely to have swiftly moved forward with Phase 3 as it has done with several other of its properties. Speculation by 2014 that Actavis is staying quiet BECAUSE bimatoprost is a known success is almost assuredly wrong. Companies do not offer press releases for failed products. They stay quiet until they announce their pipeline on a going forward basis (something Actavis said it plans to do during its next R&D day), and the products that don't make the cut are silently dropped. Thus, silence does not = success.

Now, I'm not saying bimatoprost has failed. I really have no idea. It may or may not be one of the many clinical programs Actavis hopes to push forward in the relatively near term. But we know that it is not currently in Phase 3, and we also know that it could be a long time before we are made aware of success/failure. All I want to say is that the business analysis (not necessarily the scientific analysis, which I think is generally sound) taking place on this forum is too highly speculative, in my opinion. At this point, all we can really do is wait and hope that Actavis realizes the promise of bimatoprost as a clinical and commercial opportunity.

[champpy]

Ive mentioned this before but ive been using bim for 6-7 months w no regrowth at all. Im also already using dut and fin. Any ideas why this wouldnt be working for me? Im almost 40 yrs old. Could that be the reason?

[It's2014ComeOnAlready]

I have not been following this too closely, but want to get more informed. I have two questions for you comeonits2014already:
1) Based on your research do you still have hope in this and
2) when are you going to change your name to "comeonits2015already"? haha

1) There is a lot of reason to believe this drug will work well (based on scientific studies), and will be developed. The circumstances surrounding the trials and how tight-lipped they've been, for as long as they've been (approx. 8 months since final data collection in Sept. 2014), are fishy. They haven't even disclosed the results to their shareholders, which is both unusual, and tells me they are protecting their investment by doing so. Loose lips sink ships. I think it has a lot to with other parties having access to developing bimatoprost. They don't want anyone to know it works until they have a licensed product themselves. They have the potential of losing money if the word is out before they have their own product.

On the other hand, revealing that the trial failed isn't that big of a deal for a company like this, as they have deep pockets as anyone in big pharma. They have a lot of lucrative and likely successful products in their pipeline, anyway. They wouldn't keep things this quiet for this long unless it's a success, given that bimatoprost is accessible to many different parties. That's my take.

2) I would consider changing it if it's possible. I'll change it every year until a new treatment satisfies me, then I will no longer be on this forum lol

[Hankylord]

I was having a look at Duke's 2014 study on bimatoprost (https://clinicaltrials.gov/ct2/show/...t=X431256#othr), and, unless I'm reading the results wrong, 17 weeks of using 0.03% bimatoprost resulted in a mean increase in total hair count of 27.4% in the target area, and a 12.1% increase in terminal hairs.

Surely this seems more effective than minoxidil, and especially at such a low dose...?

[cookies]

Enough trails have failed in phase II or III.

[burtandernie]

Either it failed or it didn't. Just have to be patient. Like with Follicept, SM, and whatever else. Most things tend to end in failure generally though.

I dont know I would think with the money at stake they would spot most failures pretty early on before going to larger ones. With how close this is to release its hard to see it spectacularly failing at such a late stage, but certainly possible

[burtandernie]

Sometime btwn Nov 2015 and Jan 2016, believe it or not.

Wow that is soon. I hope it works amazingly well.

[It's2014ComeOnAlready]

What is the timeline on when this comes out if everything goes on track? The timelines on this stuff is ridiculous the amount of years for something to get through.

Sometime btwn Nov 2015 and Jan 2016, believe it or not.

[BiqqieSmalls]

For all we know, they could be in Phase III trials right now.

[jamesst11]

I have not been following this too closely, but want to get more informed. I have two questions for you comeonits2014already:
1) Based on your research do you still have hope in this and
2) when are you going to change your name to "comeonits2015already"? haha

[burtandernie]

What is the timeline on when this comes out if everything goes on track? The timelines on this stuff is ridiculous the amount of years for something to get through.

[It's2014ComeOnAlready]

what's happening on Monday?

this is a very intriguing situation here, The trials have been done for months but this company is very hush hush about this product, they have many other products on the pipeline so releasing failed results really wont hurt them much.

There must be something happening behind the scenes with this product.

I think the circumstances are unusual. According to the clinical trial page for phase 2b, the study was actually completed in September, so they would have known by then if it was working. They have kept quiet about it for months and months. They haven't even disclosed results to shareholders, and from everything I've read, anytime someone on a hair loss forum asked about it, they acted as if they've never heard of the drug. I think it's because other parties have legal access to mass production of bimatoprost.

If it failed, I'm not so sure it would be detrimental to say so. This company is huge with tons of products already, and in the pipeline. They wouldn't be so timid to release failed results of a drug, and wouldn't wait nearly a year to say it failed. This isn't some biotech startup with all their hopes on one or a few drugs, this is BIG pharma. Allergan believed in this drug all along, and were not deterred by the phase 2a study.