Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[unbalding]

Then show us something

Increased androgen receptor and remodeling in the prostatic stroma after the inhibition of 5-alpha reductase and aromatase in gerbil ventral prostate.

http://www.ncbi.nlm.nih.gov/pubmed/19484778

[It's2014ComeOnAlready]

I didn't say it didn't work for me. If you actually understood what you read, you would know that I just started using it today.

So minoxidil is not a treatment because you rub it on your head? Great logic you have.



Which is exactly why I'd like to try a higher concentration. I'm not paying close to $1,000 though for something that is unproven. Perhaps if we could see the results from the latest trial I could justify it, but not based on rumors of great results. Besides, D-Cloprostenol is similar to bimataprost, only about 50x stronger, but hasn't shown much in the way of results.

Ok, you don't understand the difference between rubbing a drug on your head by itself and what rogaine does. Rogaine has a vehicle to deliver the drug to the scalp.

Plus you said people have tried similar treatments to setipiprant with little success, and then you mentioned ramatroban as one of those drugs. Learn how to write and use logic, please.

[It's2014ComeOnAlready]

There is absolutely no basis for this comment. The Kythera speaker specifically stated that they will be using a novel delivery approach that Upenn has patent protection on. It could very well be the wounding protocol. We just don't know at this point.

No, I do know. A "novel delivery approach" could easily be a topical treatment that Cotsarelis mentioned year after year in his interviews about PGD2. The wounding protocol is distinctly used to create new hairs, not keep or strengthen the ones you already have. Please go read the studies.

[RGPHILPA]

This has nothing to do with wounding. Their trials for follicular neogenesis involved wounding, this is a new treatment to prevent hair loss.

There is absolutely no basis for this comment. The Kythera speaker specifically stated that they will be using a novel delivery approach that Upenn has patent protection on. It could very well be the wounding protocol. We just don't know at this point.

[It's2014ComeOnAlready]

That's debatable.

Then show us something

[unbalding]

Does taking propecia increase DHT or DHT receptors over time? No.

That's debatable.

[unbalding]

So, you're doubting that this will work at all because rubbing ramatroban on your head didn't work? Hm. They're spending millions of dollars to trial setipiprant for hair loss in a "novel approach." I sincerely doubt that this "novel approach" is rubbing a chemical all by itself on your head. I wouldn't call that a treatment, I'd call that rubbing a chemical on your head without any sort of vehicle.

I didn't say it didn't work for me. If you actually understood what you read, you would know that I just started using it today.

So minoxidil is not a treatment because you rub it on your head? Great logic you have.

Also, the issue with bimatoprost in trials had been concentration. In their phase 2b study, they upped the concentration 10X. 0.03% is very weak for hair loss, but it works for eyelashes.

Which is exactly why I'd like to try a higher concentration. I'm not paying close to $1,000 though for something that is unproven. Perhaps if we could see the results from the latest trial I could justify it, but not based on rumors of great results. Besides, D-Cloprostenol is similar to bimataprost, only about 50x stronger, but hasn't shown much in the way of results.

[RGPHILPA]

Does anyone have any details on this wounding protocol? Is it a chemical peel? Mechanical? And how many cell layers does it penetrate? I was able to find this but not too much else: http://www.uphs.upenn.edu/news/News_...06/cotsarelis/

If you look up follica's patents, they have many different ways of wounding. I know one of their techniques involved using lasers. They've put a lot of work into to developing the procedure - quite impressive. Check them out:

http://www.faqs.org/patents/assignee/follica-inc/

[It's2014ComeOnAlready]

Does anyone have any details on this wounding protocol? Is it a chemical peel? Mechanical? And how many cell layers does it penetrate? I was able to find this but not too much else: http://www.uphs.upenn.edu/news/News_...06/cotsarelis/

This has nothing to do with wounding. Their trials for follicular neogenesis involved wounding, this is a new treatment to prevent hair loss.

[RGPHILPA]

Theoretically, but people have tried similar treatments that are already available with little to no success. I don't see how setipiprant should be any better than ramatroban. There are a substantial number of people out there who have used that along with various pgf2 analogues, and no miracle results have been reported. I myself just started using ramatroban today along with bimataprost .03%, and will start using D-cloprostenol next week. I'd love to try a higher concentration of bimataprost or latanaprost if I could find a reasonable price on quality powder.

Laypeople have no clue what they're doing. They're just grabbing stuff off the shelf and slopping it on their heads and expecting regrowth. It's not that simple. Pharmaceutical companies spend significant resources and hire scientist who specialize in formulation development for a reason - it's difficult to get it right. The dose, the vehicle, frequency of administration etc... all need to be figured out precisely. They have significant effects on exposure, 1/2 life and toxicity. So, it's not surprising that no results were seen.

I wouldn't say this thing is a done deal. They'll still need to demonstrate efficacy that tops minoxidil and fin to really have a break through product. I think your average bald dude (i.e. those not on the forums) doesn't think minoxidil and fin will do a thing for them. My buddy is a classic example, hes a NW5 who tried minoxidil for a few months. He saw zero regrowth and gave up on it. I think a lot of people experience the same thing. For this treatment to become a big deal, they're gonna have to get impressive results. Something where, when you go on the drug, you get a very noticeable cosmetic result. That's really what will bring in the mainstream bald guy who's not familiar with anything that's discussed in these forums. I'm guessing that this efficacy will need to be 25% or more regrowth with a very high patient response rate. A homerun, where the treatment becomes a blockbuster, would probably have to approach 50% regrowth. To me, this is their biggest obstacle; getting a very high efficacy. It's not been achieved before.. It's fantastic that they already know it's a safe, well tolerated drug; which is the biggest killer of drugs in the clinic. So we have a good jump on it already.

I think this is our best shot - it's utilizing the most advanced understanding of MPB that the world has. Fingers crossed on the proof of concept!

[It's2014ComeOnAlready]

The concern for me is does your body compensate by increasing PGD2 further or producing more PGD2 receptors, thus making a permanent treatment more difficult when that comes along.

Does taking propecia increase DHT or DHT receptors over time? No.

[Energizer]

Wounding

Does anyone have any details on this wounding protocol? Is it a chemical peel? Mechanical? And how many cell layers does it penetrate? I was able to find this but not too much else: http://www.uphs.upenn.edu/news/News_...06/cotsarelis/

[It's2014ComeOnAlready]

Theoretically, but people have tried similar treatments that are already available with little to no success. I don't see how setipiprant should be any better than ramatroban. There are a substantial number of people out there who have used that along with various pgf2 analogues, and no miracle results have been reported. I myself just started using ramatroban today along with bimataprost .03%, and will start using D-cloprostenol next week. I'd love to try a higher concentration of bimataprost or latanaprost if I could find a reasonable price on quality powder.

So, you're doubting that this will work at all because rubbing ramatroban on your head didn't work? Hm. They're spending millions of dollars to trial setipiprant for hair loss in a "novel approach." I sincerely doubt that this "novel approach" is rubbing a chemical all by itself on your head. I wouldn't call that a treatment, I'd call that rubbing a chemical on your head without any sort of vehicle.

Also, the issue with bimatoprost in trials had been concentration. In their phase 2b study, they upped the concentration 10X. 0.03% is very weak for hair loss, but it works for eyelashes.

[unbalding]

I honestly believe there is a race to get setipiprant, as well as bimatoprost out there. You won't need anything else, treatment wise. One will stop hair loss, and the other will regrow spots you need it in. That's it. That's one of the reasons I find this very exciting.

Theoretically, but people have tried similar treatments that are already available with little to no success. I don't see how setipiprant should be any better than ramatroban. There are a substantial number of people out there who have used that along with various pgf2 analogues, and no miracle results have been reported. I myself just started using ramatroban today along with bimataprost .03%, and will start using D-cloprostenol next week. I'd love to try a higher concentration of bimataprost or latanaprost if I could find a reasonable price on quality powder.

[It's2014ComeOnAlready]

I would also like to make clear why I am so gung ho about this development. Cotsarelis has been working on the PGD2 thing since 2007, and he has selected a particular drug (one that has been exhausted in clinical trials) and a company to trial and produce it.

It says that 5 drugs worked in this pathway, but they chose this one because of it's efficacy with hair, but also because of how studied it is. This is not some company taking a chance at a potential new hair loss drug. All the hard work has been done, and they want to commercialize this as soon as possible. All the steps and measures have already been taken to ensure that this will work and they'll be successful. The trial is the least daunting part about it.

Other doctors, news outlets, Cotsarelis himself have always been very confident about this. We should be too if a pharmaceutical company wants to produce it. Companies don't put on more clinical trials with a drug that hasn't worked for something else, unless it surely works for something they can commercialize it for.