Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[walrus]

If a drug works, technically it is a side effect, only it happens to be a desirable one.

[sdsurfin]

Please ask your professor about Zyrtec and Claritin withdrawal (if you look online most people who take antihistamines long term seem to get it) and ask if this might cause similar problems. If this doesn't carry that risk then sleepiness and headaches might be the worst you get from it.

[Gerhard]

thanks man. I'm just trying to help and be realistic. I wish we could just gene edit already and be done with this crap, it's so unfair. See if you can research and ask people whether blocking this receptor long term will cause withdrawal like with zyrtec. Unfortunately i cnt find a contact email for kythera, if i was in san diego i would try to talk to the lead researcher. i think hoping for a side effect free drug is silly though. its amazing that people take propecia without side effects, and I'm not sure this kind of receptor blocker is really good for long term use.

I'm sure all of us wish gene editing was a thing, but that's something I doubt we'll ever live to see. I plan on going to the laboratories tomorrow to actually discuss it with one of the biology professors. I'm curious if they have any insight.
Kythera's email is located on their website, but they seem to only take them if you're a certified healthcare professional. Otherwise they seem to mandate a call. I would agree with you about a side effect free drug, but the aim so far is to find a drug with a more limited amount of side effects with a lower rate of eventually having them.

[sdsurfin]

thanks man. I'm just trying to help and be realistic. I wish we could just gene edit already and be done with this crap, it's so unfair. See if you can research and ask people whether blocking this receptor long term will cause withdrawal like with zyrtec. Unfortunately i cnt find a contact email for kythera, if i was in san diego i would try to talk to the lead researcher. i think hoping for a side effect free drug is silly though. its amazing that people take propecia without side effects, and I'm not sure this kind of receptor blocker is really good for long term use.

[Pentarou]

Half of you are incredible whiners.. The other half, are selfish and inpatient, wanting the product right now by any method and any means. No doubt if you got it and cured your hair loss, you would never come on these forums and help other people out... Time to grow up, this is the most promising news in the last decade at least, in 2012 cotsarelis said trials would start within 2 years, they started In 2013..just one year(they said they have been testing for 2 years already) ! Turns out he is honest after all..

Honestly, I feel optimistic for the future for the first time since about July 2013. Yes, there are still a lot of hurdles ahead, let's be realistic, but otherwise I can't see this as anything but a promising step forward.

[Gerhard]

that link has nothing to do with sides. also i don't think short term sides will be a huge issue. I do think long term sides will be ****ed, if you do your research on other histamine receptor blockers, people go through really horrid withdrawals after trying to stop after long term use. I guess we can cross our fingers that more selective PGD2 blockers won't do the same, but my hopes are not high. Would love to talk to a doctor or researcher about this.

I'll do some research on them tonight and get back to you. Although I hate the fact that balding struck me and especially at such a young age I can at least admit that it's made me more interested in the science behind dermatological issues such as hair loss and has made me even consider tackling it as a potential career choice if I can manage. For now, I'll leave this thread with this: I hope that by having a more selective blocker that they will enable a less side effect riddled treatment that propecia. Honestly, while I may be taking this, I have come to grips with the fact that what I'm putting in my body for vanity's sake is toxic. While I am cautious for side effects in these PGD2 blockers I would say I'd be more willing to experiment and trial them than I ever would be and am with propecia. The hormonal effects of propecia just seem so much more catastrophic if they come to fruition.

I would also like to say to you personally, sdsurfin, that while your words haven't been widely appreciated in this or a few other topics that I am grateful for your presence and posts on these forums. While we may not want to hear about the potential of ineffective or bum treatments, it is important that we are notified of the possibility of these not coming to bear.

Hopefully Setipriprant will blow us all away. For now I'll remain cautiously optimistic.

[sdsurfin]

that link has nothing to do with sides. also i don't think short term sides will be a huge issue. I do think long term sides will be ****ed, if you do your research on other histamine receptor blockers, people go through really horrid withdrawals after trying to stop after long term use. I guess we can cross our fingers that more selective PGD2 blockers won't do the same, but my hopes are not high. Would love to talk to a doctor or researcher about this.

[Gerhard]

pee and poo. No sides.

In other trials it supposedly came back with headaches and some other side effects which I would determine to be rather mild to insignificant. This is good news though. I'm being tentative and cautious with how much optimism I allow myself to feel due to the nature of some individuals posts in this thread. Remember guys, just because their words aren't good news doesn't make them invalid. I'm happy to hear any update good or bad (but primarily good). From what I've read so far we need more time to pass to allow Kythera to showcase their efficacy. In the link to their interview I heard very little discussion on Setipriprant as it mostly focused on their cosmetic injection filler.

We will have to wait for an update as to where they stand on FDA testing. Funding however, thankfully, seems to be less of an issue with Kythera so far. They make it sound affordable and relatively inexpensive for them which means we won't have to deal with as many stalls. I do hope that this does offer a new treatment, but I am making sure not to put too much hope into this. CB showed me how quickly hope can become despair if left there too long. Speaking of CB has anyone actually found a proper vehicle and found conclusive evidence of its efficacy yet?

[It's2014ComeOnAlready]

An open access publication on how the drug is metabolised: http://link.springer.com/article/10....268-013-0031-7

pee and poo. No sides.

[walrus]

An open access publication on how the drug is metabolised: http://link.springer.com/article/10....268-013-0031-7

[burtandernie]

If there ever was a time to be positive about some amazing news that came out of nowhere it would be now. You just need some patience. I would feel a little better once we see a little more about how well it works and what sides might emerge later on. This though might be the biggest news in a long time. It might get good regrowth and you throw BIM in the mix you might get a lot of hair back for the first time in history

[HairlossAt15]

Half of you are incredible whiners.. The other half, are selfish and inpatient, wanting the product right now by any method and any means. No doubt if you got it and cured your hair loss, you would never come on these forums and help other people out... Time to grow up, this is the most promising news in the last decade at least, in 2012 cotsarelis said trials would start within 2 years, they started In 2013..just one year(they said they have been testing for 2 years already) ! Turns out he is honest after all..

[It's2014ComeOnAlready]

But again, those trials failed. We don't have any information about hair regrowth from those trials.

Dutasteride is considered efficient by anyone in the scientific community, and still hasn't received approval as a hair loss treatment. Why would a drug with failed trials and no assurance of efficacy as a hair loss treatment would have better luck than dutasteride?

And beware about any company promises. If you haven't, please read the archives from the Intercytex and Aderan efforts. People here and elsewhere even went to the point of cancelling HTs and making projected milestones timelines because they were told "that everything is in place for it to be a successful and efficient program towards commercialization.". Seriously, even Aderans had plans to roll out the treatment in Bosley clinics

Also, remember Follica. It's Cotsaserlis company too and it's been a decade of disappointments.

I think it's too early for this level of excitement

I don't think you understand all of the information and circumstances. Those trials did not fail, the trials went fine, the drug wasn't commercialized because it didn't work for asthma.

Dutasteride has nothing to do with this.

These are not company promises, this is based on all the information in their presentation, if you actually took the time to read it.

Cotsarelis and Follica have been working for a decade on this and follicle neogenesis. He's sold to a pharmaceutical company so they can develop a new treatment based on all his work. A company is paying to do the trial based on the working hypothesis of the leading hair researcher in the world. They are taking on the cost, which means they believe in it. Companies do not trial drugs, especially drugs that have been through this many trials, unless it is highly likely to succeed and be commercialized.

It's not too early for this level of excitement if you understand what's going on, and how Cotsarelis' work has gotten to this point.

[bigentries]

It's not new in terms of development with the FDA. That's what's counts. Drugs that have been commercialized have made it through fda trials, which is why they've been released. This drug hasn't been released as anything else because what it was originally intended for (asthma) didn't have much of an effect. Nevertheless, it has been through 8 clinical trials, including a phase 3. This drug would be different because there would be no sexual side effects, plus women would be able to use it.

Cotsarelis is one of the most (if not the most) knowledgable doctors in hair research. This is his work, and he sold the rights to have it developed. If you read the presentation, it says that everything is in place for it to be a successful and efficient program towards commercialization.

But again, those trials failed. We don't have any information about hair regrowth from those trials.

Dutasteride is considered efficient by anyone in the scientific community, and still hasn't received approval as a hair loss treatment. Why would a drug with failed trials and no assurance of efficacy as a hair loss treatment would have better luck than dutasteride?

And beware about any company promises. If you haven't, please read the archives from the Intercytex and Aderan efforts. People here and elsewhere even went to the point of cancelling HTs and making projected milestones timelines because they were told "that everything is in place for it to be a successful and efficient program towards commercialization.". Seriously, even Aderans had plans to roll out the treatment in Bosley clinics

Also, remember Follica. It's Cotsaserlis company too and it's been a decade of disappointments.

I think it's too early for this level of excitement

[It's2014ComeOnAlready]

It is a new drug, it has never been commercialised

Dutasteride has been commercialised, has been involved in several clinical trials, and it's widely prescribed off-label as a hair loss treatment because the medical community considers it safe and effective.

And still, it's not officially approved for hair loss, and it's been years since the approval process started. Why is this drug any different?

Cotsareli's involvement is not a guarantee of success. He also had some success with wounding and lithium almost a decade ago and that lead nowhere, any attempt from forum members to replicate those results failed

It's not new in terms of development with the FDA. That's what's counts. Drugs that have been commercialized have made it through fda trials, which is why they've been released. This drug hasn't been released as anything else because what it was originally intended for (asthma) didn't have much of an effect. Nevertheless, it has been through 8 clinical trials, including a phase 3. This drug would be different because there would be no sexual side effects, plus women would be able to use it.

Cotsarelis is one of the most (if not the most) knowledgable doctors in hair research. This is his work, and he sold the rights to have it developed. If you read the presentation, it says that everything is in place for it to be a successful and efficient program towards commercialization. Lol why am I going back and forth with you, you don't even know his name, you keep calling him "Cotsareli"