Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[RGPHILPA]

Does anyone have any details on this wounding protocol? Is it a chemical peel? Mechanical? And how many cell layers does it penetrate? I was able to find this but not too much else: http://www.uphs.upenn.edu/news/News_...06/cotsarelis/

If you look up follica's patents, they have many different ways of wounding. I know one of their techniques involved using lasers. They've put a lot of work into to developing the procedure - quite impressive. Check them out:

http://www.faqs.org/patents/assignee/follica-inc/

[unbalding]

So, you're doubting that this will work at all because rubbing ramatroban on your head didn't work? Hm. They're spending millions of dollars to trial setipiprant for hair loss in a "novel approach." I sincerely doubt that this "novel approach" is rubbing a chemical all by itself on your head. I wouldn't call that a treatment, I'd call that rubbing a chemical on your head without any sort of vehicle.

I didn't say it didn't work for me. If you actually understood what you read, you would know that I just started using it today.

So minoxidil is not a treatment because you rub it on your head? Great logic you have.

Also, the issue with bimatoprost in trials had been concentration. In their phase 2b study, they upped the concentration 10X. 0.03% is very weak for hair loss, but it works for eyelashes.

Which is exactly why I'd like to try a higher concentration. I'm not paying close to $1,000 though for something that is unproven. Perhaps if we could see the results from the latest trial I could justify it, but not based on rumors of great results. Besides, D-Cloprostenol is similar to bimataprost, only about 50x stronger, but hasn't shown much in the way of results.

[unbalding]

Does taking propecia increase DHT or DHT receptors over time? No.

That's debatable.

[It's2014ComeOnAlready]

That's debatable.

Then show us something

[RGPHILPA]

This has nothing to do with wounding. Their trials for follicular neogenesis involved wounding, this is a new treatment to prevent hair loss.

There is absolutely no basis for this comment. The Kythera speaker specifically stated that they will be using a novel delivery approach that Upenn has patent protection on. It could very well be the wounding protocol. We just don't know at this point.

[It's2014ComeOnAlready]

There is absolutely no basis for this comment. The Kythera speaker specifically stated that they will be using a novel delivery approach that Upenn has patent protection on. It could very well be the wounding protocol. We just don't know at this point.

No, I do know. A "novel delivery approach" could easily be a topical treatment that Cotsarelis mentioned year after year in his interviews about PGD2. The wounding protocol is distinctly used to create new hairs, not keep or strengthen the ones you already have. Please go read the studies.

[It's2014ComeOnAlready]

I didn't say it didn't work for me. If you actually understood what you read, you would know that I just started using it today.

So minoxidil is not a treatment because you rub it on your head? Great logic you have.



Which is exactly why I'd like to try a higher concentration. I'm not paying close to $1,000 though for something that is unproven. Perhaps if we could see the results from the latest trial I could justify it, but not based on rumors of great results. Besides, D-Cloprostenol is similar to bimataprost, only about 50x stronger, but hasn't shown much in the way of results.

Ok, you don't understand the difference between rubbing a drug on your head by itself and what rogaine does. Rogaine has a vehicle to deliver the drug to the scalp.

Plus you said people have tried similar treatments to setipiprant with little success, and then you mentioned ramatroban as one of those drugs. Learn how to write and use logic, please.

[unbalding]

Then show us something

Increased androgen receptor and remodeling in the prostatic stroma after the inhibition of 5-alpha reductase and aromatase in gerbil ventral prostate.

http://www.ncbi.nlm.nih.gov/pubmed/19484778

[bigentries]

There is absolutely no basis for this comment. The Kythera speaker specifically stated that they will be using a novel delivery approach that Upenn has patent protection on. It could very well be the wounding protocol. We just don't know at this point.

Yeah, I don't get where people are claiming this is going to be an oral treatment.

There's big chances the "novel delivery" has something to do with wounding, Cotsareli's has been obsessed with wounding for over a decade.

Probably why Follica seems to be reacting so well to the news

[RGPHILPA]

No, I do know. A "novel delivery approach" could easily be a topical treatment that Cotsarelis mentioned year after year in his interviews about PGD2. The wounding protocol is distinctly used to create new hairs, not keep or strengthen the ones you already have. Please go read the studies.

I have read the studies. A topical treatment isn't "novel". Minoxidil is topical.

Furthermore, you can find Cotsarelis's presentation at the World Congress for Hair research on Follica's website. That entire talk is about PGD2. He even explicitly mentions that a PGD2 antagonist type drug could be therapeutically beneficial. At the time he gave the presentation and Follica added it to their website, he was already under contract with Kythera. So, I'm not saying that it's the case for sure, but, there is ample reason to speculate that this very well could end up being used in conjunction with wounding.

[unbalding]

Ok, you don't understand the difference between rubbing a drug on your head by itself and what rogaine does. Rogaine has a vehicle to deliver the drug to the scalp.

Plus you said people have tried similar treatments to setipiprant with little success, and then you mentioned ramatroban as one of those drugs. Learn how to write and use logic, please.

Seriously? DMSO doesn't doesn't deliver the drug to the scalp? And yes, ramatroban and setipiprant are both PGD2 inhibitors. Do you not know the meaning of the word similar?

Maybe if you had a reading comprehension beyond a high school level you could actually understand what people are saying.

I don't even know why you're arguing with me. Clearly I believe in this avenue of treatment as well, or I wouldn't be experimenting with it myself.

[RGPHILPA]

Probably why Follica seems to be reacting so well to the news

Could you elaborate more? What do you mean "reacting so well"?

[It's2014ComeOnAlready]

Seriously? DMSO doesn't doesn't deliver the drug to the scalp? And yes, ramatroban and setipiprant are both PGD2 inhibitors. Do you not know the meaning of the word similar?

Maybe if you had a reading comprehension beyond a high school level you could actually understand what people are saying.

Let me rephrase that sentence so it makes more sense. Maybe if your reading comprehension was beyond a high school level, you could communicate more effectively.

Ugh, you ugly little internet troll.

[bigentries]

Could you elaborate more? What do you mean "reacting so well"?

Well, one of the company's founders is backing a rival company and giving the rights to a potential treatment. They are probably involved in some way

[barfacan]

If this truly ends up being an oral drug (if it ever even comes out), i sure as **** wont be taking it as i've learned my lesson from Propecia.