Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[hellouser]

They said the drug works in vitro, because they studied it in hair chemical pathways. It does not have sexual side effects because it was tested on hundreds of healthy men and women in an oral form, and there were no reportings. Theoretically, it will be more effective than finasteride because PGD2 is further downstream of DHT. Finasteride doesn't block all DHT, and therefore doesn't block the creation of excess PGD2.

I've been posting on this forum since 2014, but have been reading for much longer.

Finasteride along with Setipiprant and Minox should yield some impressive results. I wonder what we can get in combination with Histogen/Replicel should either of them come to fruition.

[It's2014ComeOnAlready]

You are saying that, read your posts more carefully. In your last post you affirmed the drug will work, will not have sexual side effects and will work better than propecia.

Don't you think you are getting too attached? Are you really a 2014 user? You should really read the archives to see how some guys get too attached to any treatment that brought hope

They said the drug works in vitro, because they studied it in hair chemical pathways. It does not have sexual side effects because it was tested on hundreds of healthy men and women in an oral form, and there were no reportings. Theoretically, it will be more effective than finasteride because PGD2 is further downstream of DHT. Finasteride doesn't block all DHT, and therefore doesn't block the creation of excess PGD2.

I've been posting on this forum since 2014, but have been reading for much longer.

[bigentries]

I'm not saying the drug works

You are saying that, read your posts more carefully. In your last post you affirmed the drug will work, will not have sexual side effects and will work better than propecia.

Don't you think you are getting too attached? Are you really a 2014 user? You should really read the archives to see how some guys get too attached to any treatment that brought hope

[It's2014ComeOnAlready]

Give the CTO at Kythera a call before they start their proof-of-concept trial. Its will be a waste of time and money since you already got all the answers.

It would be extremely helpful if you just read the presentation. I'm not saying the drug works, I'm saying that if it does, it would have no sexual side effects, and would theoretically be more effective than propecia. This is also based on years or research and trials. Keep listening to sdsurfin, the fear-mongering denialist. Like the fox news of hair loss message boards.

[sdsurfin]

why are sexual side effects the only important side effects? It sounds like if a drug turned your face into a goats face but left your libido intact you would still take it happily. I think constant headaches and feeling asleep all the time are just as bad if not worse. Propecia never ****ed up my sex drive too bad, but it did make me feel braindead. your brain is really the thing that matters most.

[Jonathan]

Let me make this clear to anyone reading this thread: This drug will have NO sexual side effects, NONE. This drug will be more effective than propecia because PGD2 is more causal to hair loss than DHT is. Propecia doesn't even block all DHT, so some PGD2 is still elevated downstreatm in the scalps of men who are using propecia.

IF you want to understand the relationship between DHT and PGD2 look at page 8 of this presentation:http://files.shareholder.com/downloa...0Deck%209FEB15

Enough of the "is it gonna be more effective than propecia? Will it have the sides?" YES IT WILL BE MORE EFFECTIVE. NO, THERE WILL BE NO SEXUAL SIDE EFFECTS because there were none in healthy men and women taking oral doses.

Give the CTO at Kythera a call before they start their proof-of-concept trial. Its will be a waste of time and money since you already got all the answers.

[Parsia]

Let me make this clear to anyone reading this thread: This drug will have NO sexual side effects, NONE. This drug will be more effective than propecia because PGD2 is more causal to hair loss than DHT is. Propecia doesn't even block all DHT, so some PGD2 is still elevated downstreatm in the scalps of men who are using propecia.

IF you want to understand the relationship between DHT and PGD2 look at page 8 of this presentation:http://files.shareholder.com/downloa...0Deck%209FEB15

Enough of the "is it gonna be more effective than propecia? Will it have the sides?" YES IT WILL BE MORE EFFECTIVE. NO, THERE WILL BE NO SEXUAL SIDE EFFECTS because there were none in healthy men and women taking oral doses.

Ok thanks for make it clear to us , would you please tell me when do you think ( estimation ) this product would be available in market?

Should we wait at least 3 years you think?

[It's2014ComeOnAlready]

Let me make this clear to anyone reading this thread: This drug will have NO sexual side effects, NONE. This drug will be more effective than propecia because PGD2 is more causal to hair loss than DHT is. Propecia doesn't even block all DHT, so some PGD2 is still elevated downstreatm in the scalps of men who are using propecia.

IF you want to understand the relationship between DHT and PGD2 look at page 8 of this presentation:http://files.shareholder.com/downloa...0Deck%209FEB15

Enough of the "is it gonna be more effective than propecia? Will it have the sides?" YES IT WILL BE MORE EFFECTIVE. NO, THERE WILL BE NO SEXUAL SIDE EFFECTS because there were none in healthy men and women taking oral doses.

[kaptainjack]

Even if it turns out to be only as good as Finasteride but without any of the sexual side effects, it's a winner in my books.

[RGPHILPA]

Also, a bit more evidence supporting my speculation...

Follica has posted Cotsarelis's talk at the World Congress for Hair Research on their web page. The bulk of that talk is about PGD2 and it's role in MPB. He even specifically states that an antagonist could be therapeutically effective for treating baldness. If this recent deal was engaged in outside of Follica's interests (i.e. this recent Kythera development doesn't involve them) why would they post that talk on their website? Clearly Cotsarelis was already involved with Kythera long before that talk was given. So, something is up...

Coincidence or something else?

[RGPHILPA]

This is what I got from reading this thread.
This will be an alternative to propecia but not necessarily something that will replace it. It was quoted that this is better than propecia, but by how much? I think we would have heard something if its efficacy was markedly better than propecia from all those clinical trials for asthma. And the fact they want to use bim for regrowth makes me believe their efficacy will be somewhat similar. This will definitely benefit people who gets sides from propecia, but not from this drug. But I won't expect it to be much better than propecia. And also cb may be a better alternative with less side effects in the future.
The more interesting question is will you grow more hair if you use this with propecia? There's no way to answer this without a clinical trial, but I feel that there won't be much difference. I know very little about science behind this, but someone mentioned they are part of the same chain, pgd2 is just lower level of that chain. But let's say there is an improvement from using them together. How much improvement does there have to be before it makes sense to use them together? You will be faced with added side effects and costs.
Not to say I'm not excited about this news. More options are always welcome. Some people will definitely benefit from this, especially for women who haven't had real trestment option before this. But I'm not expecting a cure. Also, the most interesting thing from this is that they sound very confident about bim. perhaps bim in conjunction with this drug and/or with dht antagonists will yield good result.

Well they specifically state in their presentation that they'll be using a novel (patented) technique that Upenn owns the rights to for delivering the drug. Nobody as of yet knows what that novel delivery approach is. So, you can't look at the allergic rhinitis trials and conclude that there will be minimal results for this compound or even have any idea of how effective it could be. This could and should be an entirely different approach.

And if I can engage in a bit of speculation.... I want to point out that one of the novel delivery techniques that Cotsarelis and Upenn have patented, are the wounding protocols that Follica was working on. Upenn has rights to that as well as Follica. Maybe we'll see another licensing deal (which I'm not even sure they need since they're on the patent) go through and this PGD2 compound will be used in conjunction with wounding. That would be a game changer for sure. And there is the not so small coincidence that Follica went silent and laid off their staff right around the time that Kythera, Cotsarelis and Upenn were entering into contracts - approximately two years ago. Right at a time when Bernat Olle from follica was saying they could generate significant hair growth. It makes no sense for them to say that and then go dead and layoff staff unless there was a significant change of direction in their business plan, such as I'm suggesting here.

I would love for that to be true, though I conceded that it may be wishful thinking.

[Allowme]

This is what I got from reading this thread.
This will be an alternative to propecia but not necessarily something that will replace it. It was quoted that this is better than propecia, but by how much? I think we would have heard something if its efficacy was markedly better than propecia from all those clinical trials for asthma. And the fact they want to use bim for regrowth makes me believe their efficacy will be somewhat similar. This will definitely benefit people who gets sides from propecia, but not from this drug. But I won't expect it to be much better than propecia. And also cb may be a better alternative with less side effects in the future.
The more interesting question is will you grow more hair if you use this with propecia? There's no way to answer this without a clinical trial, but I feel that there won't be much difference. I know very little about science behind this, but someone mentioned they are part of the same chain, pgd2 is just lower level of that chain. But let's say there is an improvement from using them together. How much improvement does there have to be before it makes sense to use them together? You will be faced with added side effects and costs.
Not to say I'm not excited about this news. More options are always welcome. Some people will definitely benefit from this, especially for women who haven't had real trestment option before this. But I'm not expecting a cure. Also, the most interesting thing from this is that they sound very confident about bim. perhaps bim in conjunction with this drug and/or with dht antagonists will yield good result.

[Gerhard]

Please ask your professor about Zyrtec and Claritin withdrawal (if you look online most people who take antihistamines long term seem to get it) and ask if this might cause similar problems. If this doesn't carry that risk then sleepiness and headaches might be the worst you get from it.

I am very interested in this myself due to your postings and will definitely inquire upon it when talking to the professor tomorrow.

Great comment. I think I know what you mean. I feel like ever since I started balding, I've learned so much about the clinical trial process, the regulatory environment, and the science involved in hair loss, aging, and dermatology issues. As much as it sucks to be going through hair loss, I feel like it has helped me understand the medical and pharmaceutical industries, and I hope it will help me evaluate scientific and medical claims more effectively.

I couldn't have phrased that better myself. The amazing thing is is that I've never even considered a career in the medical field before I began whimsically desired to cure myself and others of hair loss. Now it's actually turned into a bit of a pastime and I find myself reading a lot of dermatologic medical journals and scholarly articles. The ironic part is is that when I tried to discuss some of these findings that some people toss around and describe so easily with my dermatologist and a few other dermatologists you quickly begin to understand how little understanding they have in their own field. As you've said it's also been easier to evaluate all medical findings. I hate AGA, I truly, truly do and I would wish it upon no one. It has, however, opened my eyes to a possible career choice and an avenue for achieving it. Whether I'll take it or not remains to be soon. I certainly do hope that by the time I'm old enough to make an impact on the hair loss field that it will already be a thing of the past.

That is so strange to me that those allergy medications have that affect... I had taken zyrtec for years, and went off of it for the past 9 months, and haven't noticed a single side... Crazy to think it can be tied to things like depression and headaches!

Agreed. I'm not too keen on rereading the articles all over again currently, but due to sdsrufin's contributions I am hoping that Setipriprant will bind to receptors just enough to limit PGD2 to normal scalp levels. Otherwise this treatment will need some fine tuning.

[Slam1523]

Please ask your professor about Zyrtec and Claritin withdrawal (if you look online most people who take antihistamines long term seem to get it) and ask if this might cause similar problems. If this doesn't carry that risk then sleepiness and headaches might be the worst you get from it.

That is so strange to me that those allergy medications have that affect... I had taken zyrtec for years, and went off of it for the past 9 months, and haven't noticed a single side... Crazy to think it can be tied to things like depression and headaches!

[Thinning@30]

Although I hate the fact that balding struck me and especially at such a young age I can at least admit that it's made me more interested in the science behind dermatological issues such as hair loss

Great comment. I think I know what you mean. I feel like ever since I started balding, I've learned so much about the clinical trial process, the regulatory environment, and the science involved in hair loss, aging, and dermatology issues. As much as it sucks to be going through hair loss, I feel like it has helped me understand the medical and pharmaceutical industries, and I hope it will help me evaluate scientific and medical claims more effectively.