2013

[StinkySmurf]

Why does Aderans work?

Can I ask Desmond why you think Ji Gami will work?

I'm not talking about the science which you've demonstrated out the wazoo!

I'm asking have you spoken to or read any info from Phase 2 trial participants or any info from another ongoing study that leads you to believe cultured DP works or that cell therapy works?

Thanks!

[Desmond84]

Very nice Desmond....!

By doing a couple Google searches I stumbled upon this website after I copy/pasted some of the words in the link you provided.

http://www.biomedexperts.com/

With a free subscription you can search studies and published papers for possible new research and development regarding hair loss, and every other thing known to man.

Wow! Nice!

Well I still have access to university journals which is great!

If you guys wanna read a journal desperstely, let me know! I'll try and get it

[StinkySmurf]

Score GliaMed

well Phase 1 is generally 1-3 months. I'm just not sure if they've started it yet!

Preclinical work is definitely done though!

We just need to somehow access this report!

It's tempting for sure Desmond even at $2000, but I think you would be surprised how much you already know, and I don't think it's possible that this report could contain any information not released to the public so it's hard to know what the basis is for their analysis.

At least we picked up the name GliaMed though!!

[Desmond84]

well Phase 1 is generally 1-3 months. I'm just not sure if they've started it yet!

Preclinical work is definitely done though!

We just need to somehow access this report!

[rdawg]

Very interesting stuff Desmond, thank you for the find!

When can we expect to see early results from that?

Alot of this stuff sounds great in theory, I'd just be more interested in seeing some real results from this!

[Desmond84]

GliaMed began focusing on small molecule compounds called "immunophilin ligands".

These small molecules can induce somatic cells to adopt a stem cell phenotype in vitro and that these induced stem cells could be made to differentiate into cells of different lineages, including muscle cells, neurons and glial cells!

This class of small molecules has been termed “Regenerative Immunophilin Ligands” or RILs.

Further research in animal models showed that administration of RILs in vivo by topical, oral or parenteral routes resulted in the generation of stem cell-like de-differentiated cells at the sites of trauma, and drove rapid and enhanced regeneration of a variety of tissues, including complex skin tissues, myocytes, bone and brain.

GliaMed has shown that RILs induce the de-differentiation of adult human fibroblasts in vitro, and that when these cells are placed under appropriate culture conditions, they can be induced to differentiate into cells that express muscle-specific, neuron-specific or glial-specific markers. The mechanism of action involves induction of transcription factors such as Oct-4 and Sox-2, which are characteristic of stem cells.

The company has initiated IND-enabling studies of its lead compound for treatment of androgenetic alopecia,

GliaMed has discovered that treating wounds with RILs tips the body’s healing system toward regeneration, resulting in a remarkable reformation of normal tissue at sites of damage. In animal studies, RIL-treated full-thickness wounds have been shown to fully heal and develop all the complex skin structures, including nerves, hair follicles, sweat glands, dermis and epidermis, in less than half the time of untreated wounds.

[Desmond84]

OMG Gliamed is going into Phase 1 for Androgenetic Alopecia in 2013!

Why don;t we know anything about these guys!!!!!

[inspects]

Hey guys,

I just found the goldmine.

Here is the published report of what's in pipeline for MPB as we speak. The problem is it costs $2000 to access!

This is how they describe it: "sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources"

Take a look at the table of contents btw! It's got the products we are wishing for so badly!

http://www.fastmr.com/catalog/produc...id=528049&dt=t

Very nice Desmond....!

By doing a couple Google searches I stumbled upon this website after I copy/pasted some of the words in the link you provided.

http://www.biomedexperts.com/

With a free subscription you can search studies and published papers for possible new research and development regarding hair loss, and every other thing known to man.

[StinkySmurf]

GM-1485 from GliaMed, Inc.

Take a look at the table of contents btw! It's got the products we are wishing for so badly!

http://www.fastmr.com/catalog/produc...id=528049&dt=t

Scanning the TOC, this is my 2 cents on the $2000 dollar value:


HYUNDAI PHARM. CO., LTD. will market Minox Gel

Hygeia Therapeutics, Inc. will market two different topicals, HYG-440 and HYG-102440

Histogen and Aderans we know about, but GM-1485 from GliaMed, Inc., is another regenerative cell therapy company thats news to me.

Here is a news release from 2009 on GM-1485:

http://www.news-medical.net/news/20091118/Pre-clinical-data-of-GM1485-to-be-presented-by-GliaMed.aspx

[StinkySmurf]

Nice Little Nugget

Hey guys,

I just found the goldmine.

Here is the published report of what's in pipeline for MPB as we speak. The problem is it costs $2000 to access!

Yes, It's an interesting nugget for sure Desmond!

Thanks!

[Desmond84]

Hey guys,

I just found the goldmine.

Here is the published report of what's in pipeline for MPB as we speak. The problem is it costs $2000 to access!

This is how they describe it: "sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources"

Take a look at the table of contents btw! It's got the products we are wishing for so badly!

http://www.fastmr.com/catalog/product.aspx?productid=528049&dt=t

[Desmond84]

Am I the only one who thinks that Aderans with 60% repsonse rate which relies on genetic markers is not a hopeful treatment. I mean imagine if you are in those 40% unluckies, you can't get it and you end up with a scar of one square centimeter.
Got really disappointed hwen I've read that. Desmond seems really optimistic. On the other hand I am really pessimistic. I've started following the hairloss scene in December 2010. Only thing that changed in those 2 years is emergence of more possible potential treatments. I mean that is good but given the track record of how many of those have been proven to be ineffective or snake oils, I am really sceptical.

But hey I don't mind being wrong as long as I get my hair back...

Sogeking, the genetic test doesn't require taking a 1cm2 biopsy!

This usually involves rubbing a swab inside your cheek or a simple blood test.

The 1cm2 biopsy will only be performed once the results come back as a responder...

[Kayman]

I think it is so stupid to stop propecia because that temporary side effect. do not be spoiled and get into that damn propecia. Most people think they have side effect because they read garbage from some stupid website. if you think about it and stop taking it, one day you will regret !

Side effects like depression? anxiety? brain fog? Temporary or not those are sides I do not want just for the sakes of having hair on my head. Erectile dysfunction that lasts after you come off finasteride? This isn't garbage off of some website it's side effects that are printed on the pamphlet that come with your medicine.

[Kirby_]

Am I correct in thinking that dutasterise is literally the only advancement in hairloss treatments over the last decade? Or is dut even older than that?

[clarence]

Am I the only one who thinks that Aderans with 60% repsonse rate which relies on genetic markers is not a hopeful treatment. I mean imagine if you are in those 40% unluckies, you can't get it and you end up with a scar of one square centimeter.

square centimeter? Why in the world would they leave you with a bald square in the back of your scalp, rather than just removing the skin and then just patch it up, as is done in a regular strip surgery?