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Me too. So many drugs never got to phase 3, often for no aparent reason.
RU, CB, ASC and more that i cant think off. By 2017 i expect histogen and aderans to be with us, so these guys are wasting millions of $$ testing CB.
ASC looks so interesting. Studies show it degrades the androgen receptor (the dream!). Where is it?
The only new drugs that I think are worth some hope are the PGD2 blockers.Comment
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PGD2 blockers (crth2 antagonists) seem to work to some extent, but they are not the dream treatment many were hoping...At least the guys experimenting with OC000459 don't report any miracle, just a shedding reduction, wich is a little subjective. Anyway too soon to take conclusions, and we may try other crth2 antagonists, like TM30089, wich also seem promising...
CB seem to be making it's way to the market, at least for acne treatment, but the vehicle that will be used probably wont do much in the scalp...The studys with iontophoresis were extremely promising, but this definitly is not a simple everyday use "vehicle".
ASC-J9 seem to give more side effects on people that experimented with it, also we don't know how safe degrading androgen receptors might be, or how the body will respond to that...Personaly I wouldn't go this route.
RU is still the most successfull experimental treatment so far IMO, although long term effects are uknown, the science behind it sugests it should be relatively safe in the concentrations people are using (but no one can say this for sure, we would need longer studys/trials).
I strongely believe that there are groups of independent people that sufer from MPB making some interesting advancements, and trying some promising things...If something better comes from this, it will probably be available for people interested in pioneer experimental treatments...
Right now I can only recommend for people that want to make part of this possible/probable evolution in experimental treatments to pay atention at HLH new group buys, that are bringing some interesting things to us. Over HLH there are some guys willing to help anyone that want to know/experiment.Comment
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Am I the only one who thinks that Aderans with 60% repsonse rate which relies on genetic markers is not a hopeful treatment. I mean imagine if you are in those 40% unluckies, you can't get it and you end up with a scar of one square centimeter.
Got really disappointed hwen I've read that. Desmond seems really optimistic. On the other hand I am really pessimistic. I've started following the hairloss scene in December 2010. Only thing that changed in those 2 years is emergence of more possible potential treatments. I mean that is good but given the track record of how many of those have been proven to be ineffective or snake oils, I am really sceptical.
But hey I don't mind being wrong as long as I get my hair back...Comment
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Am I correct in thinking that dutasterise is literally the only advancement in hairloss treatments over the last decade? Or is dut even older than that?Comment
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Side effects like depression? anxiety? brain fog? Temporary or not those are sides I do not want just for the sakes of having hair on my head. Erectile dysfunction that lasts after you come off finasteride? This isn't garbage off of some website it's side effects that are printed on the pamphlet that come with your medicine.Comment
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Hey guys,
I just found the goldmine.
Here is the published report of what's in pipeline for MPB as we speak. The problem is it costs $2000 to access!
This is how they describe it: "sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources"
Take a look at the table of contents btw! It's got the products we are wishing for so badly!
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GM-1485 from GliaMed, Inc.
Scanning the TOC, this is my 2 cents on the $2000 dollar value:
HYUNDAI PHARM. CO., LTD. will market Minox Gel
Hygeia Therapeutics, Inc. will market two different topicals, HYG-440 and HYG-102440
Histogen and Aderans we know about, but GM-1485 from GliaMed, Inc., is another regenerative cell therapy company thats news to me.
Here is a news release from 2009 on GM-1485:
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Very nice Desmond....!
By doing a couple Google searches I stumbled upon this website after I copy/pasted some of the words in the link you provided.
With a free subscription you can search studies and published papers for possible new research and development regarding hair loss, and every other thing known to man.Comment
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OMG Gliamed is going into Phase 1 for Androgenetic Alopecia in 2013!
Why don;t we know anything about these guys!!!!!Comment
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GliaMed began focusing on small molecule compounds called "immunophilin ligands".
These small molecules can induce somatic cells to adopt a stem cell phenotype in vitro and that these induced stem cells could be made to differentiate into cells of different lineages, including muscle cells, neurons and glial cells!
This class of small molecules has been termed “Regenerative Immunophilin Ligands” or RILs.
Further research in animal models showed that administration of RILs in vivo by topical, oral or parenteral routes resulted in the generation of stem cell-like de-differentiated cells at the sites of trauma, and drove rapid and enhanced regeneration of a variety of tissues, including complex skin tissues, myocytes, bone and brain.
GliaMed has shown that RILs induce the de-differentiation of adult human fibroblasts in vitro, and that when these cells are placed under appropriate culture conditions, they can be induced to differentiate into cells that express muscle-specific, neuron-specific or glial-specific markers. The mechanism of action involves induction of transcription factors such as Oct-4 and Sox-2, which are characteristic of stem cells.
The company has initiated IND-enabling studies of its lead compound for treatment of androgenetic alopecia,
GliaMed has discovered that treating wounds with RILs tips the body’s healing system toward regeneration, resulting in a remarkable reformation of normal tissue at sites of damage. In animal studies, RIL-treated full-thickness wounds have been shown to fully heal and develop all the complex skin structures, including nerves, hair follicles, sweat glands, dermis and epidermis, in less than half the time of untreated wounds.Comment
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But then I'm pessimistic about anything getting released, knowing the history of MPB treatments....
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