Histogen Update - Spencer Kobren Speaks With Dr. Craig L. Ziering

[Tracy C]

I am convinced Histogen will bring a product to the world that will remove minox, fin and others from the market.

Histogen's treatment probably will knock Minoxidil off the market - but it will not knock Finasteride off the market - or remove the need for Spiro to treat women's hereditary hair loss.

In terms of shiney bald scalps out there, i think Dr Gho holds the key...

I cannot agree with that.

[neversaynever]

I am convinced Histogen will bring a product to the world that will remove minox, fin and others from the market.

In terms of shiney bald scalps out there, i think Dr Gho holds the key, but his patents are blocking progress in that department.

What worries me is how long they will take and how they plan to mass produce it.

If they plan to sell the technology to another company, it will delay things hugely. If they plan to find a partner to bring the treatment to the world, maybe it will be quicker.

But I think everyone has the right to be negative about replicel, histogen etc etc. Because after so many years of let downs, people want it NOW.

By the time they release it, I will probably have crawled too far up the norwood scale to make any real use of it. And all these % figures are a bit misleading.

But for all you nw1-3 men, and most women...i really think histogen will be there for you.

[Tracy C]

So histogen's treatment will help grow hair for us and replicel will prevent that hair and the hair you already have from fallen out again?

Replicel's treatment should do both, grow hair back and immunize hair follicles from the damaging effects of DHT. Histogen's treatment will grow hair back but it will not immunize hair follicles from DHT. Histogen's treatment will not be a permanent solution, however it looks like Histogen's treatment is going to give cosmetic results much sooner. Replicel's treatment should be permanent but so far it looks like it will take longer to get cosmetically significant results. This why using them in combination makes sense - if everything works as expected.

These are very important details that the negative Nancy's in this forum are ignoring. The Devil is in the details and the details do matter.

By the way Tracy, I've lately been hearing about Replicel's potential of immunizing healthy follicles from DHT influence. Is that just just theorized or is there some kind of in vitro study that I missed?

Dr. Hoffmann said it in a few of the introduction videos concerning female hereditary hair loss. I am not sure if he simply theorized this or if he was able to show it in vitro. However it makes sense that the treatment could do that and probably will do that.

[Pate]

1. Where did you get the info that said a few had no significant results? Can you direct me to that?
2. So people with thinning hair is there 100% chance that it will strengthen and reverse the miniaturization of those existing hairs even if it doesn't grow new hairs?
3. Do they have plans of trialing it in areas of transplanted hair?
4. We need pictures of males who were treated.
5. Bring on early release in Asia.

1. Take a look on their website, in the 'News' section, the bar chart that shows the distribution of responses at 3 months, dated July 27 2009. 3 out of 13 had no significant response.

That is only the 3 month result and I haven't seen a similar graph for 12 months, but from the difference between the best results, the mean, and the standard deviation, it is almost certain that some had no significant results at 12 months either. The mean is low and the standard deviation is high - that basically means the results were spread over a large range and some of them must have been near zero or even negative growth.

2. Probably not 100% chance but the trial so far showed around 90% positive growth at 3 months. The question is how cosmetically significant that will be. We just don't know but things are looking pretty good - those photos of the women were the first macroscopic photos we've seen and they both had a significant cosmetic effect even at 3 months.

3. Probably not in the trial phase because they need to evaluate how well it works without the influence of other hairs, scar tissue, etc. But they will try it eventually, I have no doubt. I am also interested to know how it works when combined with fin.

4. Those microscopic photos on the poster are of males. But yes, we need some new macroscopic photos. The only ones we have had so far showed no visible difference at 3 months.

5. Everyone is hanging out for early release in Asia but I am very sceptical we will see it anywhere before 2015. If I am wrong though, I will be very happy.

[doinmyheadin]

We don't need an interview for those questions, we can answer them already.

1. No, it didn't. A few had no significant results, most had somewhere around the average, and a few had excellent results significantly better than average.

2. NW4-6, not tested in slick bald areas.

3. The pilot study did not evaluate hair growth at 24 months (only safety) but said "new hair appeared to persist." No evidence on how long HSC lasts before DHT reasserts itself.

4. No. Transplanted hair was an exclusion criterion for the trial so anybody who had a transplant couldn't be in the trial.

5. Seriously doubt it.

1. Where did you get the info that said a few had no significant results? Can you direct me to that?
2. So people with thinning hair is there 100% chance that it will strengthen and reverse the miniaturization of those existing hairs even if it doesn't grow new hairs?
3. Do they have plans of trialing it in areas of transplanted hair?
4. We need pictures of males who were treated.
5. Bring on early release in Asia.

[TrueGround]

So histogen's treatment will help grow hair for us and replicel will prevent that hair and the hair you already have from fallen out again?

That is what she is is theorizing and what all of us are hoping for, yes.

Not to be rude or anything, but people need to quit asking questions that start with, "will (insert treatment) do this...?". Nothing is conclusive yet, and NOBODY knows what the full potential of these future treatments are yet.

By the way Tracy, I've lately been hearing about Replicel's potential of immunizing healthy follicles from DHT influence. Is that just just theorized or is there some kind of in vitro study that I missed?

[john2399]

Now that I know what I am looking at, I have seen it. Not a lot but too often for comfort.





The news is better than most people think it is, even with the first news release - because most people are ingoring something that is very important. If Replicel's treatment works as expected, it should immunize hair follicles from the damaging effects of DHT. Thus preventing future hereditary hair loss permanently. This means Replicel's treatment would be a true cure. Histogen's treatment won't do that, therefore Histogen's treatment will not be a true cure. However I can easily envision these two treatments being used together.

So histogen's treatment will help grow hair for us and replicel will prevent that hair and the hair you already have from fallen out again?

[Tracy C]

Yeah, I know about that, but I don't think it would pull someone's hairline so that it's receded more at the temples EXACTLY like MPB.

Now that I know what I am looking at, I have seen it. Not a lot but too often for comfort.

The good news is, Replicel's approach, if they can really get it to work, should theoretically work on bald areas. So maybe there really is hope for everyone.

The news is better than most people think it is, even with the first news release - because most people are ingoring something that is very important. If Replicel's treatment works as expected, it should immunize hair follicles from the damaging effects of DHT. Thus preventing future hereditary hair loss permanently. This means Replicel's treatment would be a true cure. Histogen's treatment won't do that, therefore Histogen's treatment will not be a true cure. However I can easily envision these two treatments being used together.

[Smiley]

I keep hearing 2014 release in Asia. Is that even possible?

Cause if it is, 'One ticket to Asia, please!'

[Kiwi]

I think Replicel came up with this new release in an attempt to save face. They wanted to highlight the most positive part of their results rather than the dismal averages. They released results that disappointed everyone, and days later, Histogen releases great results. So Replicel just put out another press release to stay in the game. Histogen still blows them WAY out of the water though.

The good news is, Replicel's approach, if they can really get it to work, should theoretically work on bald areas. So maybe there really is hope for everyone.

Where the **** did Histogen put out the press release - I've only seen one link to a PDF. Please help :P

[Nilli57211]

I think Replicel came up with this new release in an attempt to save face. They wanted to highlight the most positive part of their results rather than the dismal averages. They released results that disappointed everyone, and days later, Histogen releases great results. So Replicel just put out another press release to stay in the game. Histogen still blows them WAY out of the water though.

The good news is, Replicel's approach, if they can really get it to work, should theoretically work on bald areas. So maybe there really is hope for everyone.

[Nilli57211]

http://www.americanhairloss.org/wome..._hair_loss.asp

Scroll to the bottom.

Yeah, I know about that, but I don't think it would pull someone's hairline so that it's receded more at the temples EXACTLY like MPB. Also, I'm sure the subjects would have needed to be diagnosed with AGA rather than any other kind of alopecia, to even be included in the study. I would also think that the Histogen scientists actually checked for miniaturization (rather than hair simply being pulled out) before making their injections.

[Nilli57211]

2015 !! Dont put any hope b4 2020 !

Why do people keep saying things like this? This may be true for the US, but the process does not work like this in third world countries. The Histogen reps are saying 2014-2015, and that's probably about right, especially given their recent results.

Other countries don't have the FDA to slow things down and cause huge delays like that. The only reason Histogen was delayed as much as it was was that bloody lawsuit. Now they're back in full force and the wheels are in motion.

People should do their research before saying this kind of crap.

[WashedOut]

Histogen + topical CB = best treatment for baldness the world has yet to see. The treatments are gonna get a lot better with time but those two above are way better than what's out now.

Low chance of sides, not systemic, low hassle/pain. Just hair saving.

[Tracy C]

As for traction alopecia, I don't know that I really buy that.

http://www.americanhairloss.org/women_hair_loss/causes_of_hair_loss.asp

Scroll to the bottom.