Where are the phase IIb results for Bimatoprost?

[Hubris]

well u dont have to state the obvious. any treatment which comes to the market should be 100% proven works for everyone. otherwise there is no money... either cure or fin minox

I disagree. Minoxidil doesn't work for everyone and neither does finasteride. It isn't a reasonable standard to expect a drug to work for all people. It only needs to be significantly more effective than minoxidil for the majority of people in order to come to market.

[dutchguyhanging]

Well minoxidil doesnt work for everyone and causes initial shedding so as long as bim regrows and thickens

just saying (1) works for 100% of people and (2) causes no initial shed should be enough to market it

well u dont have to state the obvious. any treatment which comes to the market should be 100% proven works for everyone. otherwise there is no money... either cure or fin minox

[lifelonglearning]

Well minoxidil doesnt work for everyone and causes initial shedding so as long as bim regrows and thickens

just saying (1) works for 100% of people and (2) causes no initial shed should be enough to market it

[rdawg]

Found this interesting

http://www.ncbi.nlm.nih.gov/pubmed/25765294

"Bimatoprost solution represents a therapeutic option for scalp AA."

"All responding AA patches showed significant reduction in their SALT score after therapy. Area B demonstrated significantly better results regarding rapidity of response in weeks, percentage of hair re-growth and side effects compared to area A."

It clearly has an affect on hair, even at low doses, just needs a higher dose, I have no doubt that it works it's just is it to the extent that BIM can sell it over minoxidil? I think the problem here is, is it marketable? is it 10% better than min, 20%, 50% etc. if it's only 5-10% better and will cost ten times more, it may not be worth it to release.

[lifelonglearning]

Found this interesting

http://www.ncbi.nlm.nih.gov/pubmed/25765294

"Bimatoprost solution represents a therapeutic option for scalp AA."

[unbalding]

dude, i have used this http://www.scbt.com/datasheet-222336-tafluprost.html . It's WAYYYYYYYYYYYYY~~~~~ than bimatoprost. Did nothing and even accelerated shedding. On top of that- it caused nerve pain in my left arm and some tinnitus in my right ear. Furthermore, Dr Cotsarelis's PGD2 study already stated that PGF2a levels are slightly elevated in bald scalp when compared to haired-scalp. U are going to get disappointed BIGTIME if you still pin all that hope on Bimatoprost.

Rumor had it when the phase 2 trial ended that the results were superior to minoxidil. The fact that one person experimented with something similar to bimatoprost, in small doses, and had no results, is not in any way scientifically meaningful. Let's just wait for them to announce their results, ok?

[JayM]

i have my own interpretation, and i have no interest in going back and forth over it with you.

I also never said you're pulling sh-- out of thin air. I simply said that i wasn't. I think you have some reading comprehension issues.

I'm not here to try and comfort you with explanations etc, i only post what i find. If you want my thoughts on the phase 3, you can go and look for it in this thread. I'm not going to go over it again.

preach

[It's2014ComeOnAlready]

Can you tell me then how they possibly managed to get away with phase 3 being a secretive test? Doesnt that have to be disclosed or am i pulling s_ out of thin air again?

and if it does have to be disclosed, then that means they haven't started phase 3 yet and it would be another year from now, right?

I have my own interpretation, and I have no interest in going back and forth over it with you.

I also never said you're pulling sh-- out of thin air. I simply said that I wasn't. I think you have some reading comprehension issues.

I'm not here to try and comfort you with explanations etc, I only post what I find. If you want my thoughts on the phase 3, you can go and look for it in this thread. I'm not going to go over it again.

[champpy]

Kybella is not a "new" drug. It has already been released and has it's own production. The article I posted also details that the money is for new equipment to make new packaging, not to make a new drug at that plant. That plant produces mostly restasis and bimatoprost. Please read all the material I've posted recently. I'm not pulling sh-- out of thin air, I think you are ignoring a lot of the details.

"The easiest explanation is usually the most likely one" - hmm... so nothing about bim for a year, gets a mention among a number of very late stage drugs, 3 months later there is a Q3 and pipeline update event from the Allergan HQ of aesthetics, meanwhile new packaging is being created at a plant in Waco which does worldwide distribution of Latisse with 22,000 sq ft solely for making that product. Sorry you so badly want those results, but I've said all along they would not say anything until they have a product to market, and that is something that Waco article reiterated about the new drug.

There is also mention in the article that if demand for these new products increases, they will hire more workers by Q3 2016, the one year mark after what I'm predicting is a launch for bim. Believe what you want, but I don't think you're using much logic.

Can you tell me then how they possibly managed to get away with phase 3 being a secretive test? Doesnt that have to be disclosed or am i pulling s_ out of thin air again?

and if it does have to be disclosed, then that means they haven't started phase 3 yet and it would be another year from now, right?

[HelloVera]

Hoping its a Mexican stand off scenario leading up to the Congress and after it leads to a rush for a viable treatment like Bim to be bought out by these companies after seeing how close the others are. Esp if the new ones are a improvement on the big 2.

[It's2014ComeOnAlready]

It would be bold, but i think its more likely they are expanding in waco because of the release and expected demand of kybella. I want to be hopeful but sometimes they easiest explanation is the most likely one. I really want to be proven wrong though man. there's just no real evidence that a hair loss product is any further along then those other phase 3 drugs

Kybella is not a "new" drug. It has already been released and has it's own production. The article I posted also details that the money is for new equipment to make new packaging, not to make a new drug at that plant. That plant produces mostly restasis and bimatoprost. Please read all the material I've posted recently. I'm not pulling sh-- out of thin air, I think you are ignoring a lot of the details.

"The easiest explanation is usually the most likely one" - hmm... so nothing about bim for a year, gets a mention among a number of very late stage drugs, 3 months later there is a Q3 and pipeline update event from the Allergan HQ of aesthetics, meanwhile new packaging is being created at a plant in Waco which does worldwide distribution of Latisse with 22,000 sq ft solely for making that product. Sorry you so badly want those results, but I've said all along they would not say anything until they have a product to market, and that is something that Waco article reiterated about the new drug.

There is also mention in the article that if demand for these new products increases, they will hire more workers by Q3 2016, the one year mark after what I'm predicting is a launch for bim. Believe what you want, but I don't think you're using much logic.

[champpy]

It would be bold, but i think its more likely they are expanding in waco because of the release and expected demand of kybella. I want to be hopeful but sometimes they easiest explanation is the most likely one. I really want to be proven wrong though man. there's just no real evidence that a hair loss product is any further along then those other phase 3 drugs

[It's2014ComeOnAlready]

found out another bit of information that we could add to the pile -

I had no idea exactly what the Irvine CA campus was used for after the merger. Before, it was the HQ, and now the HQ is in NJ. Turns out, the Irvine CA campus is now the base for Allergan's aesthetic medicine unit. Hopefully, everyone knows by now that their R&D update takes place there. We also know that they are preparing to release a new drug, and that this drug will be distributed worldwide via their plant in Waco, which primarily makes restasis and bimatoprost based products.

Needless to say, whatever the new drug is, it is very likely that it will be something in aesthetics. After all, what purpose or significance would it serve for them to have the conference there, unless the highlight of the "show" had something to do with aesthetics?

Taking a look at their late-stage aesthetic pipeline from the last presentation, it shows kybella (launched), two acne drugs in phase 3, bimatoprost for hair growth, and dermal fillers (one had launched last month). Allergan's new thing is all about going "bold" in what they do. I believe if their going to note the importance of their aesthetic campus, and want to be bold, the way to do it is with the release of an effective hair loss product. That is bold, and the world would take notice for sure. Sure, acne treatments are good and all, but would not grab the same attention that an effective hair loss treatment would.

[breakbot]

I'm sorry, I'm not treating anyone poorly, just putting things into perspective. After every post I've made about bim, you've called me a liar, BSer, I'm dreaming, full of it etc etc. Now you're telling me how to talk to people? You think some dude on a forum is closer to the cure than Cots? DELUSIONAL! AND you had a problem with me posting about bim all this time...only to find out that I've been right on the money about pretty much everything.

Who do you think you are?

Haha I'm with you man on this. It was a joke.
Eldarlmario will cure us all.

[barfacan]

dude, i have used this http://www.scbt.com/datasheet-222336-tafluprost.html . It's WAYYYYYYYYYYYYY~~~~~ than bimatoprost. Did nothing and even accelerated shedding. On top of that- it caused nerve pain in my left arm and some tinnitus in my right ear. Furthermore, Dr Cotsarelis's PGD2 study already stated that PGF2a levels are slightly elevated in bald scalp when compared to haired-scalp. U are going to get disappointed BIGTIME if you still pin all that hope on Bimatoprost.

*PS take note im refering to hair on the balding scalp- i have no doubt that Bimatoprost works for elongating eyelashes- on top of worsening your dark eye circles and causing fat loss underneath your eyes. How do I know all these?? I have already tried all these before. Seriously, I really wished that PGF2a would work for hair gorwth on the bald scalp- but all the Data PLUS my own experience doesnt says so.

Agreed.

You're going to have to use PGE2; the REAL shit