Where are the phase IIb results for Bimatoprost?

[lifelonglearning]

Welcome back always appreciate your posts

[It's2014ComeOnAlready]

Found something that caught my eye regarding Allergan and bim.

To recap, I have said that I am certain they will release results on Nov. 4th. There's no possible way I could know whether or not a product would be launched, but if they have continued development since the phase 2b trial, it is possible. I strongly believe they would have immediately continued production, because since they plan on bringing it to market, that means it works. If it works, and meets their biggest requisite to be more powerful than Rogaine, than you can bet that Allergan or ANY company will do anything to bring it to market ASAP.

I found the mention of bim for scalp mentioned among a good number of programs that have recently been FDA approved, very encouraging. I looked at that chart in the Q2 2015 presentation, and looked up each drug (the programs they listed among 70 they are "continuing development" on). Turns out, the majority have recently (within the last 6 months) been approved by the FDA. The remainder are late phase 3.

Anyway, here is the main purpose of this post...

I found an article today which shows that Allergan is investing $7.5 million into a plant in Waco, TX. The money is for new processing equipment to make packaging for new and existing products. AND guess what, this plant produces and distributes Restasis, Refresh, LATISSE, and LUMIGAN. So, this plant produces BIMATOPROST, the main ingredient in Latisse and Lumigan. The head of the plant says the packaging is for worldwide distribution, "but declined to comment on the name or use of the new products, saying Allergan would release that information closer to the time they become available on the market."

(here's the article for reference: http://www.wacotrib.com/news/busines...7e4fe1ec5.html)

So we know a NEW product is being launched, which is why they have purchased the new packaging equipment. We know that this plant only produces a few different drugs, two of them being bimatoprost based. We also know that bimatoprost has been alive this entire time, but without mention until 3 months from a key R&D pipeline update taking place from where this project originated (Irvine, CA). The VP of Operations even tells us that Allergan will release the information of what the drug is, or is for closer to the time it becomes available on the market (something I've said all along regarding a bim launch for Allergan).

[Sogeking]

Hey soge, i saw on others website they talk also about eyelashes that's why

"RK-023 is the development code given to the new drug that is being currently tested in Japan for treating hair loss and hypotrichosis of the eyelashes in two separate clinical trials, both in the Phase II. Very little information is available about this new molecule apart from its definition as being a novel physiologically active fatty acid derivative."

http://www.geneticbaldness.com/yet-another-glaucoma-drug-in-phase-2-clinical-trials-for-hair-loss.html

phase 2a was completed in last 2011, and their phase 2B was a comparaison trial with minox. I think if they search to license it, the phase 2B is almost completed now and maybe phase 3 can be skipped as it is a non prescription drug apparently

Hey lacazette, thanks for the info.
I don't expect from this but if they can show better effectiveness and safety than minox they will surely find a place on the market.

[lacazette]

Hey soge, i saw on others website they talk also about eyelashes that's why

"RK-023 is the development code given to the new drug that is being currently tested in Japan for treating hair loss and hypotrichosis of the eyelashes in two separate clinical trials, both in the Phase II. Very little information is available about this new molecule apart from its definition as being a novel physiologically active fatty acid derivative."

http://www.geneticbaldness.com/yet-another-glaucoma-drug-in-phase-2-clinical-trials-for-hair-loss.html

phase 2a was completed in last 2011, and their phase 2B was a comparaison trial with minox. I think if they search to license it, the phase 2B is almost completed now and maybe phase 3 can be skipped as it is a non prescription drug apparently

[Sogeking]

Just put this here
R-Tech Ueno who is a japanese pharma and has his research center in KOBE center (like sisheido and regience) have a product in their pipeline for alopecia that seems to be like bimatoprost ( the company is specialised in ophtalmology and dermatology)

(RK-023) Niboprostlan , that is in phase 2B

http://rtechueno.com/en/company/busi...ness.html#rd09 (scroll down for the pipeline)

Good find.
There are no further details from their page except that it is a topical solution and that as of 8th June they are searching to license it to some partners willing to market their topical. We have no idea how effective this is.
What makes you say that it is a bimatoprost like drug?
In their details section they describe 2 sites of action for drugs. One is the DHT part the other is hair matrix through growth factors (Like FGF7 and IGF-1 - yeah I know go figure) so their topical might consist of some growth factors. And whenever I hear growth factors I need to see pictures or trial results.

[lacazette]

Just put this here
R-Tech Ueno who is a japanese pharma and has his research center in KOBE center (like sisheido and regience) have a product in their pipeline for alopecia that seems to be like bimatoprost ( the company is specialised in ophtalmology and dermatology)

(RK-023) Niboprostlan , that is in phase 2B

http://rtechueno.com/en/company/busi...ness.html#rd09 (scroll down for the pipeline)

[Hubris]

Can we not come together to find a way to make this drug available to us all, in the same way that RU is now available via anageninc?

[Trouse5858]

The hair transplant industry grosses around $1.8 billion annually. That's certainly big business, but I have a hard time connecting the dots between hair transplant surgeons trying to stay in business and those same people having enough influence to actually thwart a treatment that would be tens of dozens of times more fruitful financially. The way I understand it, the bottom line is what moves the needle for lobbyists in say, Washington DC and the Big pharma world. The thought of hair transplant surgeons unionizing and being anything but an ant to a steel toed boot seems almost like a conspiracy theory to me. But then again, I really don't know.

[allTheGoodNamesAreTaken]

Hair transplants are *BIG* Business; Many people get 2,3 or more procedures throughout their lifetimes which means big $$$ for these transplant surgeons upper class opulent lifestyles. You don't think if somebody came out with an effective treatment that they'd do everything in their power to squash it? This is resistance to innovation 101 -- rich powerful groups stand to lose alot should something better than their product/service come along.

If such treatments become available to the mainstream, then thousands of these surgeons will be put out of business. Remember, this is a smart segment of the population, they'll be able to organize and do everything they can to delay the inevitable...Doesn't mean that they'll succeed (I personally don't think they will be successful, thanks to the information age, but i do think that lobbying/buying out the competition has played a part in the delays of finding more effective treatments to date).

It's just the way things work.

I can't imagine how they could do anything to get in the way of the cell-based treatments and the drugs in trials now won't be some magical 100% reversal anyway. If something was very effective at stopping further progression I'd be much more open to the idea of a hair transplant. Continued hairloss and the prospect of an unknown number of operations is probably one of the top reasons people are hesitant to get one. I reckon knocking out that problem would probably get HT doctors more customers if anything.

[burtandernie]

I dont really agree that hair transplant doctors for example could stop some new treatment or cure from coming out. The amount of money a new treatment will bring in dwarfs any amount say hair transplant docs could put together while still maintaining their business. There are real world examples of near cures or preventative treatments that have been released without being shut down by whoever stands to profit off that. The reason there is no cure though is just its too complicated with too many unknown pieces and relationships which medicine is horrible at figuring out.

[barfacan]

Hair transplants are *BIG* Business; Many people get 2,3 or more procedures throughout their lifetimes which means big $$$ for these transplant surgeons upper class opulent lifestyles. You don't think if somebody came out with an effective treatment that they'd do everything in their power to squash it? This is resistance to innovation 101 -- rich powerful groups stand to lose alot should something better than their product/service come along.

If such treatments become available to the mainstream, then thousands of these surgeons will be put out of business. Remember, this is a smart segment of the population, they'll be able to organize and do everything they can to delay the inevitable...Doesn't mean that they'll succeed (I personally don't think they will be successful, thanks to the information age, but i do think that lobbying/buying out the competition has played a part in the delays of finding more effective treatments to date).

It's just the way things work.

[Occulus]

What's minoxidil's regrowth percentage?

I don't know, but anecdotal evidence suggests zero, and only a marginal maintenance effect.

[Trouse5858]

I m sure Lobbying has a huge effect in this whole thing. Maybe they already have a cure, but its better for them to sell all crapy products.....makes more money

I posted a comment similar to this on another thread that ended up getting buried but this conspiracy theory makes NO sense to me. I looked up how many men and women suffer from hair loss in the U.S and it exceeds 55 million total. Only a small fraction of this number (something like 1 million) actually seek treatment options for hairloss because they are so outdated and ineffective.

Just assume you have a government-funded or even independent research facility that came up with a "cure" AKA could bring a NW 7 to a NW 1. It's extremely hard to predict the cost of something so revolutionary, but just say for the hell of it, a one time treatment would cost $ 10 thousand. Then assume maybe there's a tier 2 option for working class people who could not afford that and it isn't quite as effective, but it also costs half as much. How many people would spring for this cure? I think a very conservative 70 percent of all employed people. Again, these numbers are all rough averages and guesstimations but it does give you an idea of how filthy f*cking rich you could become with a hairloss cure. .7(55,000,000) X $7,500 = over $280 BILLION dollars. lol....I haven't seen their financial statements but I don't think Fin is doing quite that well..

[Trouse5858]

I m sure Lobbying has a huge effect in this whole thing. Maybe they already have a cure, but its better for them to sell all crapy products.....makes more money

I posted a comment similar to this on another thread that ended up getting buried but this conspiracy theory makes NO sense to me. I looked up how many men and women suffer from hair loss in the U.S and it exceeds 55 million total. Only a small fraction of this number (something like 1 million) actually seek treatment options for hairloss because they are so outdated and ineffective.

Just assume you have a government-funded or even independent research facility that came up with a "cure" AKA could bring a NW 7 to a NW 1. It's extremely hard to predict the cost of something so revolutionary, but just say for the hell of it, a one time treatment would cost $ 10 thousand. Then assume maybe there's a tier 2 option for working class people who could not afford that and it isn't quite as effective, but it also costs half as much. How many people would spring for this cure? I think a very conservative 70 percent of all employed people. Again, these numbers are all rough averages and guesstimations but it does give you an idea of how filthy f*cking rich you could become with a hairloss cure. .7(55,000,000) X $7,500 = over $280 BILLION dollars. lol....I haven't seen their financial statements but I don't think Fin is doing quite that well..

[Occulus]

Don't those percentage of regrowth statements mean the percentage of what's left up there, rather than the percentage of hairs a person can possibly have on their head?

I assumed it meant 10% of a healthy head of hair. Otherwise, if you're a NW7, 10% of zero would be zero regrowth.