Follica

[PatientlyWaiting]

I am

Really? do you have pics?

How well does it work, and what dermaroller do you use?

[Koga]

But is any one even regrowing hair in that DermaRolling thread?

I am

[PatientlyWaiting]

I think they're releasing this news because they know we're onto their studies from the dermarolling thread.

I'm still sticking to my theory that dermabrasion + injections of FGF-9 will give similar results. Follica and Cotsarelis must be shaking in their boots!

But is any one even regrowing hair in that DermaRolling thread?

[DesperateOne]

I took what another member said on another forum, I think he summarized it nicely for those of us who don't like the abstract in this.

Basically the patent boils down to this:

1. Use Laser to create a wound 1mm deep. Let's call this WOUND1
2. Inject GSK3B modulator using PEO-PPO-PEO to slow down wound healing/closure as long as possible, this essentially gives more time to apply whatever topical you are going to use to induce WIHN
3. Create another wound 4mm apart from the previous wound with a depth of 1-3 mm and apply minoxidil. Lets call this WOUND2
4. Repeat in a grid like pattern covering the whole area affected by AGA.

So what this does is this:

WOUND1's healing is essentially slowed down by gsk3b. This is a brilliant idea because it's almost like having the benefits of a big open wound in a tiny wound, it's tiny but open for a longer time, it's expressing growth factors, furthermore WOUND2 causes wnt to be expressing around it's edges, notably WOUND1 (I posted a research paper on this few pages back about how bcatenin expressed not within the wound itself, but in areas surrounding the wound). Adding minoxidil to WOUND2 further expresses bcatenin in WOUND1 (and some within wound2 before it closes quickly).

http://www.jci.org/articles/view/35381

To investigate the function of GSK-3β in fibroblasts, we generated mice harboring a fibroblast-specific deletion of Gsk3b and evaluated their wound-healing and fibrogenic responses. We have shown that Gsk3b-conditional-KO mice (Gsk3b-CKO mice) exhibited accelerated wound closure, increased fibrogenesis, and excessive scarring compared with control mice.
This is my understanding of this patent.

I was just thinking the other day about a way to slow down microneedling wound healing to potentially further growth factor expression, and I found that capsaicin does a pretty good job, but I thought the idea for crazy

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054760

Abstract: The aim of this study was to develop a human model of acute wound healing that isolated the effects of small fiber neuropathy on the healing process. Twenty-five healthy subjects had the transient receptor vanilloid 1 agonist capsaicin and placebo creams topically applied to contralateral areas on the skin of the thigh for 48 hours. Subjects had shallow (1.2 millimeter) and deep (>3 millimeter) punch skin biopsies from each thigh on days 1 and 14. Biopsy wound healing was monitored photographically until closure. Intra-epidermal and sweat-gland nerve fiber densities were measured for each biopsy. Shallow wounds in capsaicin-treated sites healed more slowly than in placebo treated skin with biopsies taken on day 1 (P<0.001) and day 14 (P<0.001). Deep biopsies in the capsaicin and placebo areas healed at similar rates at both time points. Nerve fiber densities were reduced only in capsaicin treated regions (P<0.01). In conclusion, topical application of capsaicin causes a small fiber neuropathy and is associated with a delay in healing of shallow, but not deep wounds. This novel human model may prove valuable in the study of wound healing in patients with neuropathy.

[DesperateOne]

I say we start a new community trial thread for this. I will go to the local store next week and get myself a kit of needles and try to find some bum bing gel online. We can then have people buy other stuff and induce the wound thicker. What exactly do we have to apply afterwards? Minoxidil or that amox?

[simba]

We can come together as a community and beat them to the punch. We just need to continue experimenting. Its all it takes, determination and persistence. Eventually we'll get there.

Are you serious about ditching the dermaroller or were you just being flippant?

I was looking forward to using it, guess its just cb and minox now

[hellouser]

hell we are close ? is it a dream? might it happen? some rich guy pay docs and researchers and cure him self in his mansion and then post it online maybe?

i hope it will... we need it badly

We can come together as a community and beat them to the punch. We just need to continue experimenting. Its all it takes, determination and persistence. Eventually we'll get there.

[TO YOUNG TO RETIRE]

hell we are close ? is it a dream? might it happen? some rich guy pay docs and researchers and cure him self in his mansion and then post it online maybe?

i hope it will... we need it badly

[hellouser]

Oh God, if I can barely tolerate the pain now, we are going to need some sort of gel to numb the area, otherwise I can't see myself doing it. Let us know on what you have decided to use in the end, Hellouser. What about if we actually just use knitting needles, they can be found at any length and width, the problem will be the amount of time it will take to do the procedure and the PAIN!

No idea, obviously I'm only joking about getting a cheesegrater, however we should really look into replicating Follica's methods as close as humanly possible. If we can do that, we could have a cure ourselves without spending thousands of dollars and without waiting many years. We just need more people looking into the research and doing a little experimentation. With a little luck, we can easily do it.

I'd love to hear more from Desmond on this, god damn... we are so close.

[DesperateOne]

Just as I predicted, we need much harsher wounding to replicate Follica's methods, even the diagrams I posted in the dermarolling thread reflected that, where the wounds went down to where the follicle lives and wide enough to cover a follicle's surrounding area.

Screw the dermaroller, I'm buying a cheesegrater.

Oh God, if I can barely tolerate the pain now, we are going to need some sort of gel to numb the area, otherwise I can't see myself doing it. Let us know on what you have decided to use in the end, Hellouser. What about if we actually just use knitting needles, they can be found at any length and width, the problem will be the amount of time it will take to do the procedure and the PAIN!

[hellouser]

1mm in diameter is quite a large hole, the hole is also being held open by a slow dissolving gel. I wonder if this is part of the reason a dermaroller does not work as the skin will close back around the puncture wound. In contrast a 1mm permantent hole will force the skin to bridge the gap and create NEW tissue!

In regards to the actual laser and print cartridge technology I have a lot of experience with this stuff having built my own co2 laser cutter and I see no reason why it cannot be done. Im not proposing we build on though If Follica pull this off I would be more than willing to give them my custom.

Edit reading the patent back I relise it is does say the hole is 1mm in diameter but 1mm in depth. I guess the gel may still be key to creating a bridging effect?

Just as I predicted, we need much harsher wounding to replicate Follica's methods, even the diagrams I posted in the dermarolling thread reflected that, where the wounds went down to where the follicle lives and wide enough to cover a follicle's surrounding area.

Screw the dermaroller, I'm buying a cheesegrater.

[DesperateOne]

Am I missing something?

I'm unsure as to why you're touting we can "leave this curse"?

So you like your curse?

[clandestine]

This is such good news, finally we can all leave this damn curse. I will try to do my part as soon as hellouser determines the hack for us, I will be a la rat for this.

Am I missing something?

I'm unsure as to why you're touting we can "leave this curse"?

[DesperateOne]

This is such good news, finally we can all leave this damn curse. I will try to do my part as soon as hellouser determines the hack for us, I will be a la rat for this.

[Thinning87]

1mm in diameter is quite a large hole, the hole is also being held open by a slow dissolving gel. I wonder if this is part of the reason a dermaroller does not work as the skin will close back around the puncture wound. In contrast a 1mm permantent hole will force the skin to bridge the gap and create NEW tissue!

In regards to the actual laser and print cartridge technology I have a lot of experience with this stuff having built my own co2 laser cutter and I see no reason why it cannot be done. Im not proposing we build on though If Follica pull this off I would be more than willing to give them my custom.

Edit reading the patent back I relise it is does say the hole is 1mm in diameter but 1mm in depth. I guess the gel may still be key to creating a bridging effect?

You might be right. Either way I will be happy to give Follica a nice fifty k if they can cure me for good