Follica

[baldee]

No not as far as I can make out. This is a wounding method combined with a known substance that expresses a certain substance in newly healing skin. This promotes the formation of new hair. Follica appear to have IP on the wounding device only? Suggesting the biological process is quite simple.

I hope you are right. Try to get hold a copy of this:

http://www.ncbi.nlm.nih.gov/pubmed/?term=Dissociated+Human+Dermal+Papilla+Cells+Induce+Hair+Follicle+Neogenesis+in+Grafted+Dermal-Epidermal+Composites

[brunobald]

If this is about Cotsarelis latest publication, its definitely not going to hit the market tomorrow. Basically they constructed a dermal epidermal composite containing neonatal foreskin keratinocytes and Human dermal papillae cells, transplanted it unto naked mice and after 8 weeks they noted hair follicle growth.

No not as far as I can make out. This is a wounding method combined with a known substance that expresses a certain substance in newly healing skin. This promotes the formation of new hair. Follica appear to have IP on the wounding device only? Suggesting the biological process is quite simple.

[baldee]

If this is about Cotsarelis latest publication, its definitely not going to hit the market tomorrow. Basically they constructed a dermal epidermal composite containing neonatal foreskin keratinocytes and Human dermal papillae cells, transplanted it unto naked mice and after 8 weeks they noted hair follicle growth.

[joely]

Thanks hellouser, clears it up a fraction when i first read the post i was thinking it was all but ready to go

[hellouser]

Here is Follica's pipeline:

http://www.puretechventures.com/pipeline.php

Its funded by PureTech Ventures, hence the not so obvious website.

[hellouser]

If they are using a known safe substance for the topical after wounding do they need to complete a Phase III?

Hopefully not, but the snail paced cure gatekeeping businessmen, I mean the FDA, will have a final say as to how quickly they can allow Follica to release a treatment.

[brunobald]

Preclinical would be the research, and clinical would the safety trials in Phase I. They are now in Phase II.

If they are using a known safe substance for the topical after wounding do they need to complete a Phase III?

[hellouser]

"While researchers at Follica have remained somewhat coy on exactly how the process works, The Scientist reports the procedure has already sailed through both preclinical and clinical trials."

'Sailed through clinical trials'...is this possibly implying that the procedure they've tested has already gone through all phases? Or maybe just referring to Phase 1 and 2a as we previously knew?

Preclinical would be the research, and clinical would the safety trials in Phase I. They are now in Phase II.

[Scoots]

"While researchers at Follica have remained somewhat coy on exactly how the process works, The Scientist reports the procedure has already sailed through both preclinical and clinical trials."

'Sailed through clinical trials'...is this possibly implying that the procedure they've tested has already gone through all phases? Or maybe just referring to Phase 1 and 2a as we previously knew?

[brunobald]

I would guess there should be a patent out now or soon describing the process. Should make interesting reading, especially if we can replicate.

[DesperateOne]

I don't know whether to get excited about this or not, there has been a few times this year iv got exited thinking we are almost there and turns out we aren't, i get the impression this could be all we hear, in hoping they are close, any ideas once they do release something it will be available in the uk? Id like to hear more than vagrancies and from follica themselves such as how close is close and how wellitvwill work and if higher norwoods willbevable to benefit having found myself in the news paper a few times i know they don't always tell the complete truth! Don't want to put a downer on it could be amazing! But yet another game of wait and see if you ask this balding twenty something

Since its a USA based company I suspect it will be here before the UK, maybe about three more years it will go international if this does come out. I am also sick of press releases and articles giving no substance in relation to time, it seems all they want is the publicity. They really should be close because their since is really not as complex as others companies.

[hellouser]

Hard to know what to make of this. They don't say anything they haven't said before.

They are in Phase II trials. It'll be a couple years at least before we see anything worth our time.

[joely]

I don't know whether to get excited about this or not, there has been a few times this year iv got exited thinking we are almost there and turns out we aren't, i get the impression this could be all we hear, in hoping they are close, any ideas once they do release something it will be available in the uk? Id like to hear more than vagrancies and from follica themselves such as how close is close and how wellitvwill work and if higher norwoods willbevable to benefit having found myself in the news paper a few times i know they don't always tell the complete truth! Don't want to put a downer on it could be amazing! But yet another game of wait and see if you ask this balding twenty something

[optimisticyouth]

I think they're releasing this news because they know we're onto their studies from the dermarolling thread.

I'm still sticking to my theory that dermabrasion + injections of FGF-9 will give similar results. Follica and Cotsarelis must be shaking in their boots!

I don't care who we get it from so long as this generation gets to be cured!

[brunobald]

Hard to know what to make of this. They don't say anything they haven't said before.