So how close are we to a new 'cure'

[hellouser]

What happened to PGD 2 treatments already being in trials so in a few years we will have a cure?

Nothing. Some asshat by the name of Cotsarelis throughout his typical bullsh*t response of 'within 2 years' as if it were an attempt to bring more media attention to himself.

Liars, the whole f*cking lot of them.

[BoSox]

Don't forget Follica identified the growth factor as well, Fgf9. They are able to grow new hair (neogensis). Forget about maintaining or any of that bs, this will cure baldness as we know it. Just don't let all these pessimistic people on this forum distract you. It's going to happen soon, not exactly sure when, but soon. Just relax until its on the market.

[burtandernie]

I would much rather have some PGD 2 type thing or CB 03 01 get to market so I can do something to keep my hair because if I could I would never care about all this other stuff to regrow which is going to expensive, time consuming, and who knows when it will actually happen.
What happened to PGD 2 treatments already being in trials so in a few years we will have a cure?

[Henkeh91]

This will be interesting indeed!

[TO YOUNG TO RETIRE]

Arashi can you post a link?

and also Dr Nigam please keep us updated too.

indeed thats sounds perfect if its played out without sides but hair i am going too

[Dazza]

Dr Nigams just stated on HS that 2 forum members arrived who will be getting 3d DP culture !! That should be very interesting. If he can repeat Jahoda's experiment on SCID mice, but this time on human beings, man that's going to be extremely interesting !!

Woah..
This is interesting indeed. Have the two forum members names been released? Dr Nigams says one of the members is a biotech researcher? Wasn't Boldy studying this?

Dr Nigams can you name the forum members?
Best of luck to all who are participating.

[DepressedByHairLoss]

Dr Nigams just stated on HS that 2 forum members arrived who will be getting 3d DP culture !! That should be very interesting. If he can repeat Jahoda's experiment on SCID mice, but this time on human beings, man that's going to be extremely interesting !!

God bless Dr. Nigam!! He seems like one of the few people who is looking to cure hair loss!!

[Arashi]

It seems exciting, i just want to see photos to back it up that is all.

There's no photo's. This has never been tried on humans. Jahoda managed to create Human Hair follicles on Human skin, transplanted onto a SCID mouse. Now Dr Nigams is about to try it on humans. To me, that's interesting

[Conpecia]

Photographs of results get me interested. That's about it at this point.

[john2399]

From Jahoda's paper:

Hair Follicle (HF) neogenesis refers to the generation of an entirely new HF in recipient skin using HF dermal papilla (DP) cells. This has been extensively demonstrated in rodent skin , either using intact DP or using cultured DP cells. In contrast , HF neogenesis in human skin has not previously been achieved using human cells. We performed global transcriptional profiling of both intact and cultured Dp cells using Affymetrix U133 Plus 2.0 array , which revealed several pathways expressed in intact DP , which are capable of neogenesis , but absent in cultured cells, that lack the micro environmental and anatomical context of intact DP is to grow the cells in hanging drops, which results in the formation of DP spheroids. We then profiled DP spheroids for changes in gene expression and determined that the average correlation coefficient between the transcriptomes of intact DP and the cultured cells is 0.42 , whereas that between the intact DP 3D culture. To evaluate whether recapitulation of the DP signature equated to a restored inductive potential, we established a contextual human – to – human HF neogenesis assay that could be used to assess the inductive capacity of human DP cells in human skin. When we micro implanted DP spheroids into recombined foreskins placed onto the back of SCID mice, we observed marked HF neogensis by 6 weeks, showing for the first time that intact human DP can induce de novo human HFs. We conclude that the partial restoration of the transcriptional profile in human Dp cells, achieved simply by growing the cells in a 3d spherical microenvironment, is sufficient in some instances to restore the inductive capacity of Dp cell cultures and elicit human HF neogenesis.

And now Dr Nigams is about to try this on humans !! Really, if this doesn't get you interested, then what does ?

It seems exciting, i just want to see photos to back it up that is all.

[Arashi]

From Jahoda's paper:

Hair Follicle (HF) neogenesis refers to the generation of an entirely new HF in recipient skin using HF dermal papilla (DP) cells. This has been extensively demonstrated in rodent skin , either using intact DP or using cultured DP cells. In contrast , HF neogenesis in human skin has not previously been achieved using human cells. We performed global transcriptional profiling of both intact and cultured Dp cells using Affymetrix U133 Plus 2.0 array , which revealed several pathways expressed in intact DP , which are capable of neogenesis , but absent in cultured cells, that lack the micro environmental and anatomical context of intact DP is to grow the cells in hanging drops, which results in the formation of DP spheroids. We then profiled DP spheroids for changes in gene expression and determined that the average correlation coefficient between the transcriptomes of intact DP and the cultured cells is 0.42 , whereas that between the intact DP 3D culture. To evaluate whether recapitulation of the DP signature equated to a restored inductive potential, we established a contextual human – to – human HF neogenesis assay that could be used to assess the inductive capacity of human DP cells in human skin. When we micro implanted DP spheroids into recombined foreskins placed onto the back of SCID mice, we observed marked HF neogensis by 6 weeks, showing for the first time that intact human DP can induce de novo human HFs. We conclude that the partial restoration of the transcriptional profile in human Dp cells, achieved simply by growing the cells in a 3d spherical microenvironment, is sufficient in some instances to restore the inductive capacity of Dp cell cultures and elicit human HF neogenesis.

And now Dr Nigams is about to try this on humans !! Really, if this doesn't get you interested, then what does ?

[Arashi]

I want to see some amazing photos before getting interested in it.

Why ? You didn't read Jahoda's last paper ? Or do you doubt Nigams can replicate Jahoda's work ?

[john2399]

Dr Nigams just stated on HS that 2 forum members arrived who will be getting 3d DP culture !! That should be very interesting. If he can repeat Jahoda's experiment on SCID mice, but this time on human beings, man that's going to be extremely interesting !!

I want to see some amazing photos before getting interested in it.

[Arashi]

Dr Nigams just stated on HS that 2 forum members arrived who will be getting 3d DP culture !! That should be very interesting. If he can repeat Jahoda's experiment on SCID mice, but this time on human beings, man that's going to be extremely interesting !!

[Vox]

no it's not that intensive...it's like sandpapering your skin almost, except with a device that is more precise.

It looks like it would leave visible injury on bald scalps. Where this assumption about a sandpapering-like treatment comes from?