I'm just hoping they show as good of results or better and they are planning on moving ahead. Histogen is really the only treatment I have hopes for, other than CB and BNP.
Well sorry man they are not going to come out and say "we found it and it's going to be on sale in a year and it reverses everyone's condition..."
I mean you can tell from the presentations there's a few interesting things moving forward but pretty much that's gonna be it, and you can kind of tell what they are from the abstracts linked by Desmond.
I think the only potential suprises we can have will be Aderans results, developments, and possibly moving to phase 3, and Histogen's results at the 24, 36, and 48 week timelines being better than expected (but that's a long shot); but hopefully they will give hints to things like compoundability, or how HSC can be combined with other treatments... I don't know.... if they told us they have found a partner that would honestly be big too because it would mean they can move forward without making us wait
Hey guys, just an update on Dr Jahoda's presentation titled:
"Human hair follicle neogenesis using microenvironmentally reprogrammed dermal papilla cells"
As we discussed earlier, he knows why Aderans failed to regenerate brand NEW follicles!
Previous techniques used by Intercytex, Bioamide and Aderans to culture human DP cells were too simplistic!
He has found human DP cells to be far more complex than its rodent counterpart! So he designed a genius method of culturing DP cells inspired by the way it happens in nature! A 3D spheroidal culturing, which I mentioned briefly earlier!
This new method created DP cells that have maintained most of their trichogenicity! For staticians on this forum, here's some numbers:
- First, look at the method mastered by Aderans: the average correlation coefficient between the transcriptomes of intact DP vs cultured cells is 0.42
- Now look at Jahoda's method: the average correlation coefficient between intact DP vs spheroids it is 0.56, which equates to a significant restoration of an intact DP signature by 3D culture.
I have no doubt that this method of culturing DP in 3D spheroids can be perfected by 3D printers! Australia just launched its first hospital with 3D printers printing cell cultures on bio-scaffolds
Looks like, all these great breakthroughs are happening at just the right time
Comment