7th World Congress for Hair Research (2013)

[Arashi]

Hey guys, just an update on Dr Jahoda's presentation titled:

"Human hair follicle neogenesis using microenvironmentally reprogrammed dermal papilla cells"

As we discussed earlier, he knows why Aderans failed to regenerate brand NEW follicles!

Previous techniques used by Intercytex, Bioamide and Aderans to culture human DP cells were too simplistic!

He has found human DP cells to be far more complex than its rodent counterpart! So he designed a genius method of culturing DP cells inspired by the way it happens in nature! A 3D spheroidal culturing, which I mentioned briefly earlier!

This new method created DP cells that have maintained most of their trichogenicity! For staticians on this forum, here's some numbers:

- First, look at the method mastered by Aderans: the average correlation coefficient between the transcriptomes of intact DP vs cultured cells is 0.42

- Now look at Jahoda's method: the average correlation coefficient between intact DP vs spheroids it is 0.56, which equates to a significant restoration of an intact DP signature by 3D culture.

I have no doubt that this method of culturing DP in 3D spheroids can be perfected by 3D printers! Australia just launched its first hospital with 3D printers printing cell cultures on bio-scaffolds

Looks like, all these great breakthroughs are happening at just the right time

We're not far guys from a true cure!

Thanks for your always informative posts Desmond ! However 'not far from a cure' sounds a bit too optimistic IMHO. I doubt they could start clinical trials within 2 years and from thereon it's going to be at least another 5 year to get things approved.

But yeah, within a 10 year timeframe, things look very optimistic for sure !

[Arashi]

BTW, how do you know this Desmond, are you attending the conference ?

[Desmond84]

I got my hands on the journal Unfortunately, I'm not attending as much as I would have loved to!

[Desmond84]

ole ole ole ole

[Desmond84]

Well, it seems we just can't get enough of Edinburgh!

Scientists at Edinburgh University, Scotland have found the missing link on how to rapidly multiply stem cells!

They found that by genetically modifying stem cells to produce less Oct4 triggers them to rapidly mass produce!!!

Another step closer to true hair multiplication

Three cheers for our Scottish brothers

Here's the link btw:

http://www.scotsman.com/news/education/edinburgh-university-scientists-stem-cell-find-1-2918808

[Desmond84]

Hey guys, just an update on Dr Jahoda's presentation titled:

"Human hair follicle neogenesis using microenvironmentally reprogrammed dermal papilla cells"

As we discussed earlier, he knows why Aderans failed to regenerate brand NEW follicles!

Previous techniques used by Intercytex, Bioamide and Aderans to culture human DP cells were too simplistic!

He has found human DP cells to be far more complex than its rodent counterpart! So he designed a genius method of culturing DP cells inspired by the way it happens in nature! A 3D spheroidal culturing, which I mentioned briefly earlier!

This new method created DP cells that have maintained most of their trichogenicity! For staticians on this forum, here's some numbers:

- First, look at the method mastered by Aderans: the average correlation coefficient between the transcriptomes of intact DP vs cultured cells is 0.42

- Now look at Jahoda's method: the average correlation coefficient between intact DP vs spheroids it is 0.56, which equates to a significant restoration of an intact DP signature by 3D culture.

I have no doubt that this method of culturing DP in 3D spheroids can be perfected by 3D printers! Australia just launched its first hospital with 3D printers printing cell cultures on bio-scaffolds

Looks like, all these great breakthroughs are happening at just the right time

OMG guys, looks like I was right!!!!!!!

Another group of scientists from Edinburgh University have just announced they are capable of printing 3D stem cells! Here's the most fascinating part:

Dr Will Shu, from Heriot-Watt University in Edinburgh, said: "We found that the valve-based printing is gentle enough to maintain high stem cell viability, accurate enough to produce spheroids of uniform size, and most importantly, the printed hESCs maintained their pluripotency - the ability to differentiate into any other cell type."


These SPHEROIDS are exactly what Dr. Jahoda needs to mass produce DP cells! Good news just keeps on coming!

[Desmond84]

Here's the link to the article btw:

http://www.scotsman.com/news/education/edinburgh-university-scientists-stem-cell-find-1-2918808

[Desmond84]

Oops, sorry this is the link:

http://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-21328109

[UK Boy]

This is all great Desmond but how long will it realistically be before anything comes of this? It all seems so easy, Jahoda just needs to speak to the Scots, Aderans needs to speak to Jahoda and then Aderans should use this spheroid culturing technique in the phase III trials. The meeting this week is the perfect opportunity for these guys to get together, I wish that they use it to everyone's advantage and don't just waste it.

[hellouser]

This is all great Desmond but how long will it realistically be before anything comes of this? It all seems so easy, Jahoda just needs to speak to the Scots, Aderans needs to speak to Jahoda and then Aderans should use this spheroid culturing technique in the phase III trials. The meeting this week is the perfect opportunity for these guys to get together, I wish that they use it to everyone's advantage and don't just waste it.

I'm curious about this actually! Can they just substitute this with their current method without having to start Phase I and II all over again?

[FearTheLoss]

I'm curious about this actually! Can they just substitute this with their current method without having to start Phase I and II all over again?

No, they would definitely have to start at phase 1 again, they would need to test the safety of it no doubt.

[Thinning87]

lol one day a scientist will read the Desmond thread and they will learn from him and then do it and find the cure

[oppenheimer82]

This is all great Desmond but how long will it realistically be before anything comes of this? It all seems so easy, Jahoda just needs to speak to the Scots, Aderans needs to speak to Jahoda and then Aderans should use this spheroid culturing technique in the phase III trials. The meeting this week is the perfect opportunity for these guys to get together, I wish that they use it to everyone's advantage and don't just waste it.

dr nigam doesn't need to hold safety trials. he could use this spheroid technique to mass produce dp cells. anything else would require at least 10 years.

[hellouser]

No, they would definitely have to start at phase 1 again, they would need to test the safety of it no doubt.

Are you 110% sure? Theyre still our own cells though.

[SoClose]

Are you 110% sure? Theyre still our own cells though.

Even with your own cells, there can be issues with implanting them. Particularly if they are stem cells, as they are totipotent (able to differentiate into any type of cell) or pluripotent (able to differentiate into many types of cells). Given that they have this totipotency, f they receive the wrong "messages" (as it were) from the body, then there is a very large breadth of tissue types they could develop into. Ones which you would obviously not want in your scalp.

There could also be an issue with stem cells that refuse to die - think cancer.

So there is a high chance they would have to start again. Or maybe start running this trial parallel to their current one, and almost release it as an "update" in the future. Hair v1.1.