7th World Congress for Hair Research (2013)

[Boldy]

But will this ever be a reality? I don't want to seem negative, but Desmond said the jahoda experiment was conducted in the 1980s. That's like 25 plus years ago now

Of course it is reality!, Everything is possible. being depended of the big companies that fight over money and patents, will indeed delay the process(they dont give a single Fu-ck about our hair its just about they money).if you want something very much, you can get it....

we DO know exactly, (YES EXACTLY) how to culture DP cells, How to Isolate them, how to inject them back, how to check their trychonic activity, etc. everything is step by step explained in more than 50 studies. even a kid can do it (for example).


I have been doing Full time research for the past 3 months on dp cells and on each detail from A to Z. And it made me very angry, because such simple process, had been possible 30 years ago!

I have combined and taken each positive aspect of the studies, including aderans, Replicel, and tsuij- lab) for the best protocol with most yield, the only thing next is, instruct a lab to culture my cells. which is the Next ToDO..




I don't like the Püssy Beta male mindset and believe in: "Everything is possible, if you work hard enough for it! "

[Thinning87]

oh come on!

[hellouser]

But will this ever be a reality? I don't want to seem negative, but Desmond said the jahoda experiment was conducted in the 1980s. That's like 25 plus years ago now

Its not a woman's problem, so no, it will never be a reality. Society doesn't give a fvck about men.

Receding hairline? Bald? Balding? Cue-ball? You just get laughed at and become the recipient of many jokes. And men do it too (I'm *not* blaming women).

[garethbale]

its super interesting indeed !

and do you know what even more nice is?, its possible to culture 10 Dp's for 20-30 weeks, which will give you so much cells, that its possible to cure the whole US army (from nw7 to NW0), and that with just 10 starting cells, after 30 weeks.....


It has been proven, that allogenic cells, will not be refused in the Host scalp/arm. So my cells, can be used for example to treat thousands of other man..



I have read almost every dp culture study out there now, and I cant ****ing wait to give myself a new hairline (nw0 or even a NW negative)..


this is the cure.

But will this ever be a reality? I don't want to seem negative, but Desmond said the jahoda experiment was conducted in the 1980s. That's like 25 plus years ago now

[Boldy]

PS. Don't forget that these were HUMAN hair follicles forming in HUMAN skin!

NOT rats / mice !!!!

Very exciting stuff

its super interesting indeed !

and do you know what even more nice is?, its possible to culture 10 Dp's for 20-30 weeks, which will give you so much cells, that its possible to cure the whole US army (from nw7 to NW0), and that with just 10 starting cells, after 30 weeks.....


It has been proven, that allogenic cells, will not be refused in the Host scalp/arm. So my cells, can be used for example to treat thousands of other man..



I have read almost every dp culture study out there now, and I cant ****ing wait to give myself a new hairline (nw0 or even a NW negative)..


this is the cure.

[Desmond84]

PS. Don't forget that these were HUMAN hair follicles forming in HUMAN skin!

NOT rats / mice !!!!

Very exciting stuff

[Desmond84]

OK guys, I have now found the MOST FASCINATING presentation to look forward to at this year's Hair Research Congress!

Plz note, this is MOST probably where Aderans fell short at regenerating new hair follicles!

As some of you may know Prof. Jahoda is the king of Dermal Papillae (DP) cells! He implanted DP cells from his scalp into his arm and his wife's forearm and got hairs growing within 2 weeks back in 1980's!!!

Anyways, it seems like him and his crew finally cracked how to get DP cells to induce hair follicle formation!

2011 was the year of Lauser. 2012 was Tsuji and 2013 seems to be JAHODAAA

Here's the abstract to this fascinating study:

__________________________________________________ _______________________________________

HUMAN hair follicle neogenesis using microenvironmentally reprogrammed dermal papilla cells

C Higgins,C Jahoda and A Christiano
Durham, Durham, United Kingdom and Dermatology, Columbia, NYC, NY

Hair follicle (HF) neogenesis refers to the generation of an entirely new HF in recipient skin using HF dermal papilla (DP) cells. This has been extensively demonstrated in rodent skin, either using intact DP, or cultured DP cells. In stark contrast, however, HF neogenesis in human skin has not
previously been achieved using human cells. We previously performed global transcriptional profiling of both intact and cultured DP cells using the Affymetrix U133 Plus 2.0 array, which revealed several pathways expressed in intact DP, which are capable of neogenesis, but absent in cultured cells, that lack the potential to induce de novo HF growth. We postulated that one approach to restoring the 3D microenvironmental and anatomical context of intact DP is to grow the cells in hanging drops, which results in the formation of DP spheroids. We then profiled DP spheroids for changes in gene expression, and determined that the average correlation coefficient between the transcriptomes of intact DP vs cultured cells is 0.42 while between intact DP vs spheroids it is 0.56, which equates to a significant restoration of an intact DP signature by 3D culture.

To evaluate if recapitulation of the DP signature equated to a restored inductive potential, we established a contextual human-to-human HF neogenesis assay that could be used to assess the inductive capacity of human DP cells in human skin. When we micro-implanted DP spheroids into recombined foreskins placed onto the back of SCID mice, we observed dramatic HF neogenesis by 6 weeks.

HFs grew down into the dermis and produced hair fibers, showing for the first time that intact human DP can induce a de novo human HF. Thus, we show that the inductive potential of human DP cells can be restored by growth in spheroids, which can induce entirely new HFs in human skin. We conclude that the partial restoration of the transcriptional profile in human DP cells, achieved simply by growing the cells in a 3D spherical microenvironment, is sufficient in some instances to restore the inductive capacity of DP cell cultures and elicit complete human HF neogenesis.

__________________________________________________ _______________________________________________

I really wish we had a forum member there to record this talk and ask some questions...

Btw, to all the naysayers Read this study and cheer up guys

[stayhopeful]

Dude. Let's see if it even works in the first place. But don't worry, if a treatment makes it through regulation hurdles, there is a extremely low probability it is harmful

[Cookie]

Does hair cloning cause cancer? Anyone medical expert here know? Sorry if I sound discouraging, but I'm very curious.

[clandestine]

Theres a group buy that just finished and some guys will be giving it a go soon. Lets hope it;

a) works
b) is safe

BNP-32 already exists in your body and many people inject it (Nesiritide). It should be relatively safe. All the test patience used in the clinical trial were old with most likely poor health. Us younger guys should be good.

I can't find it at the moment, but I think Desmond cautioned us in some thread regarding BNP and its potential sides?

edit:
post;

http://www.baldtruthtalk.com/showpost.php?p=105429&postcount=63

thread, posted by knockin';

http://www.baldtruthtalk.com/showthread.php?t=11145

[hellouser]

I'm very curious to see how the BNP-32 trial does too, just hope the testers know what they are doing with this one...

Theres a group buy that just finished and some guys will be giving it a go soon. Lets hope it;

a) works
b) is safe

BNP-32 already exists in your body and many people inject it (Nesiritide). It should be relatively safe. All the test patience used in the clinical trial were old with most likely poor health. Us younger guys should be good.

[Kirby_]

I'm very curious to see how the BNP-32 trial does too, just hope the testers know what they are doing with this one...

[hellouser]

Hellouser - are u DEFO sure RU works and has very little sides?

Im thinking of getting on it if the Keratene pills don't work, but there has been a fair bit of speculation.

What results have u seen whilst on it?

Only sides I've got from being on my regimen are most likely from Saw Palmetto, which is a lowered libido. Though I can't be sure its cuz of Saw Palmetto either as my social and sex life has been unstable (basically I'm either at home or at work, no time for anything else or even to think about anything else).

RU hasn't given me any sides and neither has CB. Minox only makes my scalp itchy as hell (though its been greatly reduced since about 1 month ago) and the god damn FLAKES that come out of my hair, looks like it SNOWS sometimes. Its pretty bad at times so I try to limit the use of Minox. It hasn't been so bad in the last few weeks (perhaps the addition of CB had something to do with it).

Results?

Well, I switched from 2% Minox to 5% in December and started seeing massive shedding, so much so that my density was visible thinner (friend commented on it). I added 100mg of RU per 1ml in February and now that were in April and just got my haircut, things look significantly better. My hair isn't DENSE by any means, but noone can tell im thinning either unless looking pretty closely. However, my hairline has receded by 1cm since I starting MPB about 10 years ago and my temples are gone. Thus making me about a NW3 with some thinning but not very noticeable.

I'm curious to see how the group buy trials are going to go with BNP-32, from the small clinical trial, pretty much all the patients saw at least a significant change in density and growth in slick bald areas. I'm hoping it can regrow my temples and push back down my hairline by at least half a centimetre. If not, I'm going in for a procedure with Gho and getting at least 1,600 grafts but going to push for whatever is necessary to bring me back down to NW1-1.5 (should be around 2-2,500 grafts).

[MrBlonde]

Hellouser, what sides do you get?

[hellouser]

how much does that regimen cost ya? im on propecia and minox but its quite expensive.

RU costs $225/10g which at 100mg/day lasts me about 3 months.
CB costs between $130-$225/1g which at 15mg/1.5ml lasts me about 2 months.

Minox is cheap as hell, Kirkland's 5% off ebay costs about $20 and 3 bottles last me at least 4 months.

Saw Palmetto is also cheap, about $12 per 60 capsules (so lasts 2 months)

Nizoral costs me about $15 for 175ml but I don't use much, only 3 times a week and lasts me 3+ months. Per year, I'd say its is upwards of $1,000 but if it means I keep my hair, I won't hesitate for a second to pay the price.