7th World Congress for Hair Research (2013)

[Conpecia]

Thank God and Thank Des. Really needed this, been a rough week hair-wise.

[Desmond84]

Here's another very interesting study to be presented:

Fabrication and characterization of epithelial and mesenchymal scaffolds for engineering hair regeneration

J Oh, J Lim and M Kim
Immunology, Kyungpook National University School of Medicine, Daegu, Republic of Korea and Biomedical Science, Kyungpook National University Biomedical Research Institute, Daegu, Republic of Korea

The field of hair follicle regeneration is advancing rapidly, and there have been a number of major achievements over the last decade. Nonetheless, most current technologies are still unable to maintain its in-vivo characteristic in-vitro on the field of hair biology. The creation of new hair follicles for the treatment of alopecia using tissue engineering is promising however never tried before.

To recover and enhance the competent hair inducing ability of epithelial and mesenchymal cells, we tried three-dimensional scaffolds for making functionally working epithelial structure for human and mouse hair regeneration study.

The bladder-sub mucosal sponge (BSM hybrid sponge) shows the intrinsic activation of melanocyte once we insert inductive dermal papilla sphere. It could be applicable to the study of epithelial mesenchymal signaling pathway. We found that the Fiber sheet with Keratin enhance twice the cell spreading and adhesive property compared with other supplements such as Hyaluronic acid. The human outer root sheath keratinocytes did make cluster onto the mouse newborn epithelial skin scaffold (NESS) However the distribution is uneven due to the physical damage during preparation. This study speculated the possibility of using scaffold for hair regeneration study as point of epithelial cells. The present findings could be relevant model for epithelial and mesenchymal cells to advance our understanding of the hair regeneration and cure for hair loss.

__________________________________________________ ____

To simplify it, Tsuji lab creates a hair germ by creating a 3D scaffold that allows different types of stem cells to interact with each other and form a hair germ!

Now, finding an optimal scaffold for creating the hair germ has been challenging!

These Korean scientists, have come up with a scaffold called "The bladder-sub mucosal sponge" which can be used to create a hair germ in humans!

Good news keeps on coming

[Thinning87]

I vote Desmond for the 2016 Elections

[Desmond84]

Desmond,
I get so excited every time I see you make a fresh post. I honeslty want to jump for joy.. I was just being a depressed idiot in my room. I can't tell you how badly I need tangible good news...

Brother, you are too kind

TBH, this hairloss has become my passion in life! I've made this curse my reason for living trying to solve it has become my goal! There isn't a night I would go to bed without reading a journal article or a textbook on tissue engineering!

If you really can't get your mind off it, I recommend you doing the same! Knowledge is power brother.

Keep on fighting

[ANW]

Does the Follica carcus still have a pulse ?

Been reading through the abstracts and came across this one. For those that have been around long enough, you might remember Follica were heading down the road of new hair generation following wound healing. Interestingly L Garza an associate of G Costeralis (Uni of Penn) from whom Follica licensed the original technology still seems to have some interest.


1488
Interleukin 6 promotes adult de novo hair follicle organogenesis through STAT3 phosphorylation

A Nelson, A Katseff, S Resnik and L Garza Dermatology, Johns Hopkins School of Medicine, Baltimore, MD

Adult de novo organogenesis holds great promise in regenerative medicine. As a model system of regeneration, we study Wound-Induced Hair follicle Neogenesis (WIHN), where embryogenesis is recapitulated after full-thickness excisional wounding and de novo hair follicles are counted within the healed wound. To identify causes of natural variation, we screened gene expression differences between mice with high and low WIHN levels. Interleukin 6 (IL-6) was identified as prominently upregulated in mice with increased WIHN. We hypothesized that IL-6 and subsequent STAT3 phosphorylation promotes WIHN. Both IL-6 and STAT3 phosphorylation are increased immediately after wounding and in the reepithelialized keratinocytes. Levels of IL-6 mRNA (n=4; p<0.05) and protein (n=3; p<0.05) positively correlated with regeneration ability among mouse strains. Exogenous addition of recombinant IL-6 during wound healing significantly increased WIHN in C57BL/6J mice (n=20; p<0.01). Paradoxically, WIHN is also significantly increased in IL-6 null mice, compared to strain-matched (C57BL/6J) controls (n=45; p<0.01), highlighting the complexity associated with tissue regeneration. However, phosphorylation of STAT3, a downstream mediator of IL-6 signaling, is also significantly increased in IL-6 null mice versus controls (n=4; p=0.02), suggesting that other IL-6 superfamily members that also activate STAT3 compensate for IL-6. Indeed, the IL-6 family member oncostatin M (OsM) is significantly increased (n=4, p<0.01) in IL-6 null mice compared to strain-matched controls. Underscoring its importance, pharmacological inhibition of STAT3 phosphorylation inhibits WIHN in both wild-type (n=6–9; p=0.01) and IL-6 null mice (n=7–9; p=0.03). In all, these findings demonstrate that IL-6 and STAT3 phosphorylation trigger hair follicle regeneration. These results suggest targets to promote de novo hair morphogenesis in human clinical trials and also argue against generalizations about inflammatory mediators negatively impacting regeneration.

[hellouser]

Desmond,
I get so excited every time I see you make a fresh post. I honeslty want to jump for joy.. I was just being a depressed idiot in my room. I can't tell you how badly I need tangible good news...

What do you guys think about this??? 20 percent regrowth... What is propexia and minoxidil? Do you think this solves the problem for a NW 2/3 in conjunction with scarless FUE?

I think its going to be very very possible... but if you want my prediction, YES.

[stayhopeful]

Desmond,
I get so excited every time I see you make a fresh post. I honeslty want to jump for joy.. I was just being a depressed idiot in my room. I can't tell you how badly I need tangible good news...

What do you guys think about this??? 20 percent regrowth... What is propexia and minoxidil? Do you think this solves the problem for a NW 2/3 in conjunction with scarless FUE?

[Desmond84]

The abstracts for the presentations are now published! Here's the link:

http://www.nature.com/jid/journal/v133/n1s/full/jid201397a.html

Search for "Histogen" on this page to find the abstract

Unfortunately, no pictures are posted YET! That will be presented at the conference

[john2399]

Good news. Desmond your amazing at finding news. Terminal growth is awesome. If pictures back this up, we got a solid treatment coming.

[Artista]

Des....great reporting! Thanks

[rdawg]

Where'd you get that??

Pictures?

[Desmond84]

Hey guys,

Here's the Final Phase 1/2 results for Histogen! Here's what they will be presenting at the "International Investigative Dermatology Congress":

Embryonic-like cell-secreted proteins induce hair growth in a phase I/II trial in male pattern baldness

GK Naughton,1 M Zimber,1 J Peralta-Arambulo,2 T Reyes-Cacas,3 M Hubka,1 D Ehrlich1 and J Mansbridge

Histogen, Inc., San Diego, CA, 2Asian Hair Restoration Center, Pasig City, Philippines and 3Marc Medical Group, Manila, Philippines

A Phase I/II clinical trial was performed to study the safety and efficacy of a bioengineered human cell-derived formulation, termed Hair Stimulating Complex (HSC), in stimulating hair growth in subjects with male pattern baldness. HSC contains naturally secreted growth factors known to be important in hair growth, including Follistatin, KGF, and VEGF.

The clinical study was a double-blind, randomized, two center trial in 56 subjects. All subjects tolerated the eight 0.1cc intradermal injections at baseline and 6 weeks well, and no signs of an adverse reaction were reported. Blood and urine samples taken before and after each injection set showed no liver, kidney, or bone marrow toxicity. Trichoscan image analysis of treated sites were taken at baseline, and 12, 24, 36, and 48weeks.

At the 12 week time point significant improvements in total (p=0.0013), terminal (p=0.0135) and vellus (p=0.033) hair growth over baseline was seen as was an increase in cumulative thickness density (p=0026). The primary efficacy endpoint of increased terminal hair at 12 weeks was met, with a 19.5% increase seen, a 49.5% increase over the same endpoint in our proof-of-concept trial. In addition, unlike currently approved products, HSC induced hair growth in the temporal recession as well as vertex and mid scalp regions, and was highly effective in men over 40 years of age. At the 48 week time point there continued to be a significant increase in total hairs over baseline (p=0.028). These results clearly demonstrate the safety and efficacy of intradermal injections of HSC in subjects with androgenetic alopecia.

__________________________________________________ _________

[Artista]

Jman91, Don't read into whatever tone Spencer may or may not have had. Spencer Kobren has always been quite objective on his discussions of treatments and of hair loss possibilities.
Spence knows to be very impartial on TBT and here on the BTT .
Keep a positive outlook Jman, we may be very surprised this year.
Hang in there.

[jman91]

What did he say??

he said from what he knows there will most likely not be anything groundbreaking being presented.

[ANW]

does someone have a link to the Jahoda study ?