7th World Congress for Hair Research (2013)

[Thinning87]

so maybe i have not been paying attention, but what is going on? will something not be available in 2015?

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[szn]

so maybe i have not been paying attention, but what is going on? will something not be available in 2015?

[DepressedByHairLoss]

Enough with the negativity. This is exciting.

I know we can at times be guarded regarding the progression of future treatments; we've been burned before. But this is legitimately exciting.

Let yourselves go a bit, fellas. Let your hair down.

I know, you're totally right. No wonder Spencer says to take what people say on these forums with a grain of salt, because of all the extreme negativity that goes on here.

[Conpecia]

Enough with the negativity. This is exciting.

I know we can at times be guarded regarding the progression of future treatments; we've been burned before. But this is legitimately exciting.

Let yourselves go a bit, fellas. Let your hair down.

C'mon Clan, doesn't it piss you off to think how long we'd have to wait for this to hit the market? I'm not saying this is terrible news; I'll take a cure at 40 over no cure, no doubt. But man I guess I just discovered BTT at the wrong time because 3 years ago we were at the MOST 5 years away from next gen treatments that would blow minox and fin out of the water. I think that's what many of us are upset about. And no one can deny that it's a huge blow to think you'll be fine by 2015 and then see it's going to be at least 5 more years of hell, each year the road to recovery getting more and more difficult.

Anyways, I've had my negative nancying for the week, time to focus on other shit and look forward to the World Congress.

[hellouser]

And one more thing. I get ****ing tired of guys coming on this forum and acting like we're a bunch of pussies for expressing the realistic view. If you're an alpha male you don't give a **** about your hairloss to begin with and you're nowhere near a baldness forum. If you're on this forum you're self-conscious about the way you look and that's weak and vain. Period. Stop putting people down with the beta comments. You're beta by default.

+1

Even the alpha males would rather have hair than not if given the choice. Beta or not, every guy is self conscious to some degree. Why should this even be frowned upon?

[Conpecia]

And one more thing. I get ****ing tired of guys coming on this forum and acting like we're a bunch of pussies for expressing the realistic view. If you're an alpha male you don't give a **** about your hairloss to begin with and you're nowhere near a baldness forum. If you're on this forum you're self-conscious about the way you look and that's weak and vain. Period. Stop putting people down with the beta comments. You're beta by default.

[hellouser]

I'm not sure I read the excerpt correctly: Does it not say that they used mice in the assay? I see they claim human HF in human skin but I'm missing language that states they actually implanted the spheroids in men not mice...

And man, this seems like it's still 20 years away if you start thinking clinical trials and timelines, safety testing, commercialization. I agree with Patiently, it's a Pyrrhic victory. Let me ask a question: Would you take an NW0 right now in exchange for the face and body of someone 20 years older? I sure as hell wouldn't. But that seems like what we're gonna be getting. And even worse, that trade would still be favorable from a pure hairloss perspective because we wouldn't have to go through 20 years of suffering. There's just no way out. Unless you go balls to the wall with HT's and meds, if you're between 18 and 30 it seems like you're going to be losing the hairloss battle throughout the prime of your life. We'll be cured at the expense of youth.

Hit the nail on the head.

Everytime theres a cure on the horizon, it takes 10+ years for it to even be available. But by then everyone that's been suffering has already gone completely bald and not a single shit is given and we're stuck with the next crop of great men completely destroyed by this disease.

I think theres more to the story than just money, because the supply of balding men is endless.

[Conpecia]

I'm not sure I read the excerpt correctly: Does it not say that they used mice in the assay? I see they claim human HF in human skin but I'm missing language that states they actually implanted the spheroids in men not mice...

And man, this seems like it's still 20 years away if you start thinking clinical trials and timelines, safety testing, commercialization. I agree with Patiently, it's a Pyrrhic victory. Let me ask a question: Would you take an NW0 right now in exchange for the face and body of someone 20 years older? I sure as hell wouldn't. But that seems like what we're gonna be getting. And even worse, that trade would still be favorable from a pure hairloss perspective because we wouldn't have to go through 20 years of suffering. There's just no way out. Unless you go balls to the wall with HT's and meds, if you're between 18 and 30 it seems like you're going to be losing the hairloss battle throughout the prime of your life. We'll be cured at the expense of youth.

[hellouser]

It's all about the money, and there's money to be made. Unfathomable amounts. Boldy's right. Companies want to dip their fat *****ing fingers in it, and that's good for us.

Ok, so why wasnt anyone banking on it 30 years ago??

[clandestine]

OK guys, I have now found the MOST FASCINATING presentation to look forward to at this year's Hair Research Congress!

Plz note, this is MOST probably where Aderans fell short at regenerating new hair follicles!

As some of you may know Prof. Jahoda is the king of Dermal Papillae (DP) cells! He implanted DP cells from his scalp into his arm and his wife's forearm and got hairs growing within 2 weeks back in 1980's!!!

Anyways, it seems like him and his crew finally cracked how to get DP cells to induce hair follicle formation!

2011 was the year of Lauser. 2012 was Tsuji and 2013 seems to be JAHODAAA

Here's the abstract to this fascinating study:

__________________________________________________ _______________________________________

HUMAN hair follicle neogenesis using microenvironmentally reprogrammed dermal papilla cells

C Higgins,C Jahoda and A Christiano
Durham, Durham, United Kingdom and Dermatology, Columbia, NYC, NY

Hair follicle (HF) neogenesis refers to the generation of an entirely new HF in recipient skin using HF dermal papilla (DP) cells. This has been extensively demonstrated in rodent skin, either using intact DP, or cultured DP cells. In stark contrast, however, HF neogenesis in human skin has not
previously been achieved using human cells. We previously performed global transcriptional profiling of both intact and cultured DP cells using the Affymetrix U133 Plus 2.0 array, which revealed several pathways expressed in intact DP, which are capable of neogenesis, but absent in cultured cells, that lack the potential to induce de novo HF growth. We postulated that one approach to restoring the 3D microenvironmental and anatomical context of intact DP is to grow the cells in hanging drops, which results in the formation of DP spheroids. We then profiled DP spheroids for changes in gene expression, and determined that the average correlation coefficient between the transcriptomes of intact DP vs cultured cells is 0.42 while between intact DP vs spheroids it is 0.56, which equates to a significant restoration of an intact DP signature by 3D culture.

To evaluate if recapitulation of the DP signature equated to a restored inductive potential, we established a contextual human-to-human HF neogenesis assay that could be used to assess the inductive capacity of human DP cells in human skin. When we micro-implanted DP spheroids into recombined foreskins placed onto the back of SCID mice, we observed dramatic HF neogenesis by 6 weeks.

HFs grew down into the dermis and produced hair fibers, showing for the first time that intact human DP can induce a de novo human HF. Thus, we show that the inductive potential of human DP cells can be restored by growth in spheroids, which can induce entirely new HFs in human skin. We conclude that the partial restoration of the transcriptional profile in human DP cells, achieved simply by growing the cells in a 3D spherical microenvironment, is sufficient in some instances to restore the inductive capacity of DP cell cultures and elicit complete human HF neogenesis.

__________________________________________________ _______________________________________________

I really wish we had a forum member there to record this talk and ask some questions...

Btw, to all the naysayers Read this study and cheer up guys

I don't want this to get lost, so I'm quoting it.

[clandestine]

It's all about the money, and there's money to be made. Unfathomable amounts. Boldy's right. Companies want to dip their fat *****ing fingers in it, and that's good for us.

[clandestine]

Enough with the negativity. This is exciting.

I know we can at times be guarded regarding the progression of future treatments; we've been burned before. But this is legitimately exciting.

Let yourselves go a bit, fellas. Let your hair down.

[Boldy]

Yes! Woo hoo! Can't wait, OMG! NW1, here we come, 2030 baby! It's going to happen guys, I can feel it, 2030. 40 year old's with NW1's!

Beta male Mindset.

[PatientlyWaiting]

Yes! Woo hoo! Can't wait, OMG! NW1, here we come, 2030 baby! It's going to happen guys, I can feel it, 2030. 40 year old's with NW1's!

[hellouser]

oh come on!

Its been possible for 30 years and it hasnt been made a reality. It gets little attention just like prostate cancer, the awareness for that is relegated to a MONTH where as all other womens issue are constantly pushed to the public.

30 years dude.

What a disgrace and failure.