Dutasteride

Collapse
X
 
  • Time
  • Show
Clear All
new posts
  • ChrisM
    Senior Member
    • Jun 2012
    • 299

    #46
    Originally posted by WarLord
    I don't see any reason, why the combination of fin and dut should be "poisonous". I only think that it is unnecessary. I have been on this combination for 11 weeks already, because it turned out that finasteride did NOTHING in me (well, except incessant shedding). In fact, it was an utter joke, as for the suppression of my DHT levels.

    After those 11 weeks, my DHT levels FINALLY started to decline on the level that is typical for average finasteride users (from 25-32 ng/dl to 17 ng/dl). And it took 1.25 mg fin + 0.25 mg dut! The next week, I will jump on 0.375 mg dut + 1.25 mg fin, which would roughly equal to the effect of 0.5 mg dut. In the next months, I plan to quit finasteride completely, but I still have 20 pills (=80 days), so it would be unreasonable to throw it into a scrap basket.

    On my example, you can see that finasteride is completely ineffective in some men. The reason obviously lies in the large standard deviation of DHT suppression, as this graph demonstrates:



    The average is more or less the same in all studies (-70% DHT), but some guys can experience -90% suppression, while others less than -50%. On sufficiently high dutasteride doses, these differences quickly disappear. Therefore, I keep telling young people: Don't waste your time with finasteride. It was a breakthrough at its time, but now it is an outdated drug. There is no rational reason, why you should start finasteride as the first treatment.

    BTW, the only side effects that I have noticed on dutasteride are increased libido and acne on my back.
    First off no one said anything about " poisonous" save your counterpart Patiently Waiting. I said it was unwise to mix the taking of two oral DHT inhibitor where both have in some cases a variety of sexual side effects that come with them. That's it. It was unwise to do so based on logical and reasoned common sense choices. That's my opinion here.

    Now as to your other statement about Finasteride being an outdated 20 year drug whose time has past is a subjective opinion of your own that you are trying to import to others as a fact. That is patently false as a general statement that is made as if you were an expert in the field.

    That is your opinion like my own which you are free to have based on your own subjective experiences but it is hardly a known fact. Scientific clinical trials would beg to differ with you in terms of evidence showing that Finasteride still after 20 years has a lot of mileage to go in terms of it positive hair regrowth in men over all of that time.

    And it still is one of the most widely prescribed or generically distributed DHT inhibitors to this day. It would not be if the majority of bald men so no results whatsoever.

    It would have failed in the first 5 years of its introduction or less in the market had it not shown tested and proven results over a period of time and not been around for as long as it has so far.

    It has worked and continues to work for others here on this forum board.

    And you also would just mention like Patiently Waiting you are actively now using both and taking both in your systems right now. It has worked for me and reversed out a considerable area of baldness after 10 months and I am looking to see what it does past 10 months and into a year and past that hopefully. If it doesn't I can wean myself off of Finasteride and start Dutasteride safely which is what I am promoting here. Cycling off of one drug safely before starting the next one. Period.

    So if Fin were that useless in efficacy then why are you both still taking it in combination with Dutasteride right now ? That makes no sense as you would just be taking Dutasteride followed with whatever regimen of topical you might use in concert with that. Your actions contradict your use of charts and your previously made statements.... negating them actually.
    If there was a total confidence on your part in Dutasteride alone as the goto drug and that Fin was a waste of time then neither of you would still be taking Finasteride today mixing any dosages and you would just be on Dutasteride. From what you are saying then you are both throwing money away on one product while the other is producing your gains and results.

    Comment

    • ChrisM
      Senior Member
      • Jun 2012
      • 299

      #47
      Video of propecia's results over time.




      Clinical studies information


      the chart can be seen here

      https://www.****************/hair-lo...ride-doses.pdf

      Clinical studies on the effects of oral finasteride, a type 11 5(x-reductase inhibitor, on scalp hair in men with male pattern baldness
      Introduction
      Ever since the clinical observations of James Hamilton over fifty years ago, investigators have sought the identification of the specific androgens responsible for the development of male pattern baldness (Androgenetic Alopecia). In 1974, the description of men with genetic deficiency of type II 5a-reductase shed further light on this issue. These men were found to have low serum dihydrotestosterone, normal or slightly elevated serum testosterone, and no prostate enlargement or male pattern baldness. This led to the search for 5a-reductase inhibitors as potential pharmacologic agents for treatment of disease in man.
      Clinical studies Finasteride, an orally-active type 11 5a-reductase inhibitor, was the first such agent developed for clinical use in man. Clinical trials conducted for the treatment of men with benign prostatic hyperplasia established the excellent safety profile of this compound. Studies were subsequently initiated for the treatment of men with male pattern baldness. Concurrently, finasteride administration was shown to result in increased hair growth in the stumptail macaque, and to lower scalp skin dihydrotestosterone in balding men. We conducted two separate, placebo-controlled clinical trials to evaluate the safety and efficacy of finasteride in men age 18 to 35 years old with Hamilton classification III vertex and IV male pattern baldness. Finasteride 5 mg/day or placebo was administered orally for 12 months in one study, while finasteride 1 mg, 0.2 mg, or 0.01 mg/day or placebo was administered for 6 months in a second study.
      Materials and methods
      Objective improvement in hair growth in men with male pattern baldness was determined by analysis of haircounts from macrophotographs taken of a 1

      inch diameter circle (5.1 cm) of scalp hair centered at the leading edge of the vertex bald spot.- Subjective improvement was determined by analysis of: 1) a self-administered patient hair growth questionnaire (HGQ); 2) investigator clinical assessment (ICA) of hair growth; and 3) assessment of global photographs (GPA) by a panel of expert dermatologists.
      Results
      Table 1 summarizes the results of these studies.

      Patients treated with finasteride at 5 mg, 1 mg or 0.2 mg/day showed improvement in hair growth at 6 months (M6) or at 12 months (M12), while treatment with 0.01 mg/day was similar to the placebo. Serum dihydrotestosterone (DHT) was reduced to castrate levels in patients receiving finasteride at 5 mg, 1 mg or 0.2 mg/day, while serum testosterone (T) remained in the normal range. No significant safety issues were identified in patients receiving finasteride at any dose.

      Conclusions
      In these studies, oral treatment with finasteride at doses from 0.2 to 5mg/day resulted in clinically significant improvement in hair growth in men with male pattern baldness. These studies are currently ongoing at the 1mg dose of finasteride to obtain longer-term data.

      Comment

      • mark-1
        Member
        • Mar 2009
        • 84

        #48
        So inhousepharmacy is legit?

        Which of the 3 alternatives of avodart would you recommend? I can't really afford the most expensive one.

        Comment

        • ChrisM
          Senior Member
          • Jun 2012
          • 299

          #49
          Originally posted by mark-1
          So inhousepharmacy is legit?

          Which of the 3 alternatives of avodart would you recommend? I can't really afford the most expensive one.
          A one month supply 30 pills of Avodart where I am buying my Finasteride currently is about 39.95 USD (dollars) so forty dollars plus tax . Two months is going to be about slightly over 80 dollars and up from there. Dutasteride is about as cost effective as I have seen most medications that are generics or prescription based.

          Hell... when I started Minoxidil when it first hit the scene in the early to mid
          1990's Upjohn sold an aerosol can probably with 12 fluid ounces or less for over 60 dollars closer to 70.

          Now that was expensive! And the aerosol can barely got you through the month!

          And it wasn't even the Minoxidil concentration we have today where you can get the 5 percent foam or liquid now . The Minoxidil then was probably barely two percent.

          Comment

          • BigThinker
            Senior Member
            • Oct 2012
            • 1507

            #50
            Originally posted by WarLord
            I don't see any reason, why the combination of fin and dut should be "poisonous". I only think that it is unnecessary. I have been on this combination for 11 weeks already, because it turned out that finasteride did NOTHING in me (well, except incessant shedding). In fact, it was an utter joke, as for the suppression of my DHT levels.
            This is my biggest fear. I've been shedding like fkn crazy lately, and whether I get my hair stabilized is to be determined.

            How long did you wait before you decided fin wasn't doing anything?

            Comment

            • Shan
              Senior Member
              • Feb 2013
              • 366

              #51
              Originally posted by BigThinker
              This is my biggest fear. I've been shedding like fkn crazy lately, and whether I get my hair stabilized is to be determined.

              How long did you wait before you decided fin wasn't doing anything?
              You should give Fin at least a year

              Comment

              • PatientlyWaiting
                Senior Member
                • Jan 2011
                • 1637

                #52
                Originally posted by mark-1
                So inhousepharmacy is legit?

                Which of the 3 alternatives of avodart would you recommend? I can't really afford the most expensive one.
                Before I purchased Dutagen, I googled their manufacturer Ranbaxy, from a quick glance at their website and clicking trough it, they seemed legit to me. They are a huge billion dollar Indian pharmaceutical company, no reason to think their Dutasteride are illegitimate. Their Dutasteride is the cheapest in inhouse so I got theirs because I could not afford Dr Reddy's or GSK [manufacturer for Avodart] for a full year.

                Comment

                • WarLord
                  Senior Member
                  • May 2012
                  • 343

                  #53
                  Originally posted by BigThinker
                  This is my biggest fear. I've been shedding like fkn crazy lately, and whether I get my hair stabilized is to be determined.

                  How long did you wait before you decided fin wasn't doing anything?
                  The timeline of my ordeal with finasteride is as follows:

                  26th June 2012 - started fin, 1 mg/day
                  Early August 2012 - an explosive regrowth along my hairline; big joy!
                  September/October 2012 - regrowth suddenly stopped; nothing to report
                  Late October 2012 - March 2013 - my hairline in temples is hit very brutally; losses, losses, losses. After 3 months, my left temple was borderline transparent to the depth of 1-1,5 cm. I felt like a medieval martyr.
                  Late November 2012 - I increased my fin dosage to 1.25 mg/day, but without any effect
                  December-January 2012 - Blood tests betray that my DHT is not as suppressed as one would expect in the average finasteride user (25-32 ng/dl). In other words, fin apparently doesn't work in me properly. I realized that the summer regrowth may have been due to the concurrent use of SARMs that I was taking during July-August. There still exists the possibility that my shed is only temporary, but perhaps, the quitting of SARMs may have caused some adverse hormonal reaction???
                  9th February 2013 - I couldn't handle the incessant losses anymore and added dutasteride, starting on 0.5 mg every 4th day
                  March 2013 - hairloss in temples finally slowed down
                  Mid-April 2013 - hair in temples stabilized, but still nothing remarkable to report with regard to regrowth (although one small area of my left temple largely regrew almost overnight). Some parts of my temples have thinned to such a degree that I can't imagine that they would fully regrow back, but I will see.

                  My DHT was 17.7 ng/dl on 11th April, after 3 weeks on fin+0.25 mg dut/day. This shows that I am on the right track! I must get the DHT down to 10 ng/dl in the following weeks.

                  Currently I take 1.25 mg fin/day + 0.375 mg dut/day (3 capsules every 4 days). This dosage should roughly equal to 0.5 mg dut/day.

                  Comment

                  • Dannyfire
                    Junior Member
                    • Apr 2013
                    • 22

                    #54
                    I have just started taking 1mg of Propecia a day, if i was to add 0.5mg of Dustasride to my regime would this be daily or every 4 days?

                    And out of the 3
                    Dutagen
                    Dutas
                    Avodart

                    Which one should i buy? They look the same but are differenct prices?

                    Thanks alot.

                    Comment

                    • WarLord
                      Senior Member
                      • May 2012
                      • 343

                      #55
                      Originally posted by Dannyfire
                      I have just started taking 1mg of Propecia a day, if i was to add 0.5mg of Dustasride to my regime would this be daily or every 4 days?

                      And out of the 3
                      Dutagen
                      Dutas
                      Avodart

                      Which one should i buy? They look the same but are differenct prices?

                      Thanks alot.
                      In theory, it shouldn't matter. Here you can see DHT levels after a single dose of dutasteride (GI198745).




                      And here you have another study, testing various doses, in various intervals, including 2.5 mg dut/week:




                      Based on these data, I think that dosing once in 3-4 days should be fine. Using once a week can already produce some fluctuations, although they are still very small. Look at the variance in DHT levels in finasteride!

                      Comment

                      • Dannyfire
                        Junior Member
                        • Apr 2013
                        • 22

                        #56
                        Thanks alot for the reply mate, im thinking of ordering Dutagen and taking one 0.5mg tablet every 3-4 days is the ok or would you recommend Avodart instead?

                        Also shoukd i get some Retin A cream? Thanks

                        Comment

                        • WarLord
                          Senior Member
                          • May 2012
                          • 343

                          #57
                          Originally posted by Dannyfire
                          Thanks alot for the reply mate, im thinking of ordering Dutagen and taking one 0.5mg tablet every 3-4 days is the ok or would you recommend Avodart instead?

                          Also shoukd i get some Retin A cream? Thanks
                          You can't get a recipe for Avodart? I wouldn't trust internet pharmacies.

                          Rather, I order it from China. I plan to buy about 5 grams of dutasteride powder from a Chinese supplier. I will quickly know from my blood profile, if it is legit. I think that I will need higher dosages than 0.5 mg/day to achieve my goals.

                          If you were not satisfied with the results, you can add minoxidil, but it is a life-long commitment.

                          Comment

                          • Woodyy
                            Senior Member
                            • Apr 2013
                            • 112

                            #58
                            Just ordered some Dr Reddy's Dutas from InHouse, I'm just going to take the kitchen sink approach to this thing now, I don't even care.

                            Comment

                            • BigThinker
                              Senior Member
                              • Oct 2012
                              • 1507

                              #59
                              Originally posted by Woodyy
                              Just ordered some Dr Reddy's Dutas from InHouse, I'm just going to take the kitchen sink approach to this thing now, I don't even care.
                              Keep us posted. I've been thinking the same thing increasingly as each day passes.

                              Comment

                              • Woodyy
                                Senior Member
                                • Apr 2013
                                • 112

                                #60
                                Originally posted by BigThinker
                                Keep us posted. I've been thinking the same thing increasingly as each day passes.
                                Will do. 2 questions for anyone that can help:

                                1. Considering I'm on finasteride at the moment (which didn't cause me a shed) moving onto dut is less likely to cause me a shed compared to if I'd gone straight on dut right? I mean my DHT levels are only going to drop another 20/30% or so and so I hope I should be alright.

                                2. Looking at the graphs there doesn't seem to be much benefit on taking Dut every day, would taking it EOD or MWF be almost as effective?

                                Cheers brahs.

                                Comment

                                Working...