2013

[rdawg]

Very interesting stuff Desmond, thank you for the find!

When can we expect to see early results from that?

Alot of this stuff sounds great in theory, I'd just be more interested in seeing some real results from this!

[Desmond84]

well Phase 1 is generally 1-3 months. I'm just not sure if they've started it yet!

Preclinical work is definitely done though!

We just need to somehow access this report!

[StinkySmurf]

Score GliaMed

well Phase 1 is generally 1-3 months. I'm just not sure if they've started it yet!

Preclinical work is definitely done though!

We just need to somehow access this report!

It's tempting for sure Desmond even at $2000, but I think you would be surprised how much you already know, and I don't think it's possible that this report could contain any information not released to the public so it's hard to know what the basis is for their analysis.

At least we picked up the name GliaMed though!!

[Desmond84]

Very nice Desmond....!

By doing a couple Google searches I stumbled upon this website after I copy/pasted some of the words in the link you provided.

http://www.biomedexperts.com/

With a free subscription you can search studies and published papers for possible new research and development regarding hair loss, and every other thing known to man.

Wow! Nice!

Well I still have access to university journals which is great!

If you guys wanna read a journal desperstely, let me know! I'll try and get it

[StinkySmurf]

Why does Aderans work?

Can I ask Desmond why you think Ji Gami will work?

I'm not talking about the science which you've demonstrated out the wazoo!

I'm asking have you spoken to or read any info from Phase 2 trial participants or any info from another ongoing study that leads you to believe cultured DP works or that cell therapy works?

Thanks!

[Desmond84]

Can I ask Desmond why you think Ji Gami will work?

I'm not talking about the science which you've demonstrated out the wazoo!

I'm asking have you spoken to or read any info from Phase 2 trial participants or any info from another ongoing study that leads you to believe cultured DP works or that cell therapy works?

Thanks!

Look honestly, I don't think it will generate new hairs! But I have come to a logical conclusion that it will halt further hair loss (based on the science I described earlier)

Think about it:

- Propecia is proven to work for up to 10 years (it may even be working longer, but we just haven't researched it further than 10 years yet. Ppl on this forum have been on it for 12-15 years and can vouch for it!)

- SO, DHT is the major factor!

- Testosterone must bind to Dermal Papillae (DP) receptors to produce DHT!

- If your newly implanted DP cells don;t have the receptors then in theory your hair will continue to grow just as it would with Propecia!

- If you;ve lost some hair in the waiting process till you get your hands on Ji Gami, Histogen can hopefully bring some of it back!

- Worse comes to worse, you can get a small Gho transplant to cover the receded hairline and your hairloss should be controlled permanently!

Hope this helps brother

[StinkySmurf]

Million Dollar Answer

Look honestly, I don't think it will generate new hairs! But I have come to a logical conclusion that it will halt further hair loss (based on the science I described earlier)

- Worse comes to worse, you can get a small Gho transplant to cover the receded hairline and your hairloss should be controlled permanently!

Hope this helps brother

It helps absolutely. I would still love to hear some results from someone who participated in phase 2, but your arguments are very convincing that this is a sort of immunization therapy, and you hit the nail on the head with your last statement. I don't want to spell it out too much, but HM will be good times for everyone

[StinkySmurf]

stuff in the report

besides talking to HM phase 2 trial participants or Intercytex trial participants or whatever, that report could contain information from interviews with leading scientists, which could definitely tell us something, or it could contain opinions from hair transplant surgeons which you have to take with a grain of salt.

That TOC is very big, but with a paid report like that the number of true gold nuggets is gonna be small so it could just be GliaMed for us. $2000 is not a lot for an investor to pay to know the things you can learn in this forum, but any of the above info is good to know.

[Pate]

The first thing I would do is contact the companies directly. They may be able/willing to provide more information.

I tend to agree that this report probably does not contain much in the way of unreleased info. It's more of a data compilation of available info.

It's funny how these have all slipped under our radar. Nobody has been talking about GliaMed or Hygeia even though the info has been out there for all to see.

Although the Hygeia website doesn't seem to have been updated since 2010, which can't be a good sign. Not seeing much action from GliaMed either.

Where did you find that GliaMed are going into Phase I in 2013, Des?

[inspects]

There is certainly a LOT of research going on right now to fight hair loss, I would have to bet in the next couple years there will be a product on the market with little to no side-effects for the vast majority of people, and hopefully affordable for all the young people who need a product so desperately to stop further loss.

Hopefully a growth product will be available just as soon. If you think about all the research happening at the moment at all corners of the world, its really incredible, what is even more mind-boggling is how difficult it is to develop a product to regrow hair on a majority of different type individuals with varying degrees of hair loss.

[Banana Republic]

Rosmarinus officinalis

Hi everyone,

I'm new to this forum. I've been following the discussions on different topic threads (admittedly not very thoroughly), so I have some idea of what's going on. The discussions about cutting edge/future treatments intrigue me the most, obviously.

Just out of curiosity, is there a consensus on here about the merits of plant-based therapies? I personally am not terribly excited about the idea of synthetic drugs, so the prospect of a plant-based treatment is very appealing to me. I came across an interesting and very recent study about rosmarinus officinalis (rosemary), which apparently shows promise for promoting hair growth. I've included the abstract below.

I don't know what the attitude is in this forum towards plant-based treatments -- whether it's considered hocus pocus or actually taken seriously -- so I would be curious to get your thoughts.

Thanks!

.................................................. .....

Promotion of Hair Growth by Rosmarinus officinalis Leaf Extract
Phytotherapy Research, Article first published online: 20 APR 2012

KEYWORDS

Rosmarinus officinalis;
testosterone 5α-reductase;
12-methoxycarnosic acid;
androgenic alopecia;
hair growth

ABSTRACT

Topical administration of Rosmarinus officinalis leaf extract (RO-ext, 2 mg/day/mouse) improved hair regrowth in C57BL/6NCrSlc mice that experienced hair regrowth interruption induced by testosterone treatment. In addition, RO-ext promoted hair growth in C3H/He mice that had their dorsal areas shaved. To investigate the antiandrogenic activity mechanism of RO-ext, we focused on inhibition of testosterone 5α-reductase, which is well recognized as one of the most effective strategies for the treatment of androgenic alopecia. RO-ext showed inhibitory activity of 82.4% and 94.6% at 200 and 500 µg/mL, respectively. As an active constituent of 5α-reductase inhibition, 12-methoxycarnosic acid was identified with activity-guided fractionation. In addition, the extract of R. officinalis and 12-methoxycarnosic acid inhibited androgen-dependent proliferation of LNCaP cells as 64.5% and 66.7% at 5 µg/mL and 5 μM, respectively. These results suggest that they inhibit the binding of dihydrotestosterone to androgen receptors. Consequently, RO-ext is a promising crude drug for hair growth.

http://onlinelibrary.wiley.com/doi/10.1002/ptr.4712/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=false

[inspects]

More snake oil.....

http://en.wikipedia.org/wiki/Rosemary

[Tracy C]

I don't know what the attitude is in this forum towards plant-based treatments -- whether it's considered hocus pocus or actually taken seriously -- so I would be curious to get your thoughts.

In general, plant based therapies or "natural remedies" are not going to do anything meaningful to treat hereditary hair loss. The only plant based supplement that has anything close to almost good evidence for it is a good quality Saw Palmetto Complex. Please note the word "complex". Saw Palmetto complex and straight Saw Palmetto are not the same thing.

Hereditary hair loss is a natural and normal process. It is unreasonable to expect that any "natural remedy" would be able to do anything meaningful to stop or slow down a natural process.

[StinkySmurf]

I'm always a skeptic when it comes to natural remedies, but I guess my first step would be asking to see the photographic evidence.

[Pate]

There are any number of natural substances that positively influence hair growth, especially in mice. But unfortunately the mechanism of androgenetic alopecia is so powerful, particularly in men, that it just overpowers any positive effect these therapies have.

Saw palmetto, caffeine, apple procyanidins, chilli and soy are just some examples. Now rosemary. Unfortunately it won't work any better than the others. MPB and the autoimmune response are just too strong.

But by all means give it a go if you want. Just don't expect miracles.

Thanks for the link though! If nothing else research like this might result in rosemary being added to preparations like DNC that take the 'everything but the kitchen sink' approach.