2013

[neversaynever]

Also don't forget CB. Should hear something this year, if only for the acne formulation. And hopefully find out who this "major multinational specialty pharmaceutical company" is who bought the marketing rights for it. You don't fork out $25 million unless you're confident you're onto something.

I dont know alot of CB, except some people think it will be the best topical around. Is it an anti-androgen? Any more details? The acne thing is interesting. MPB and acne definately share some issues. So I guess it blocks DHT and addresses inflammation?

[Pate]

It should easily be the best topical around. It's a strong antiandrogen and a weak anti-inflammatory so it should kill two birds with one stone.

Best of all it is quickly metabolised to an inactive metabolite, unlike any of the other antiandrogens, so it should have basically zero systemic absorption and zero sides. It will only work in the hair follicle. It's also an androgen antagonist so it blocks both types of DHT and T as well. Like RU in that regard but safer.

It will blow fin away on all counts. And everything else, google the POC trial results, they were very promising. Five applications once or twice a week resulted in 50% increase in hair count and thickness as well as 65% reduction in shedding and a big drop in sebum production.

It has one big downside and that is getting it into the follicle. Nobody has developed a suitable vehicle yet. But they are working on it.

[Desmond84]

CB could have great potential for those that suffer from side effects with fin. It blocks conversion of Testosterone to DHT but if it gets absorbed in to the blood it immediately breaks down into inactive metabolites.

The problem is, it is set for release in 2017 which is so long away! By then most of us will be either just shaving our heads or have gone down the path of Histogen + Aderans to fix things up!

It's a shame that this drug could have been released by 2002 but pharmaceutical companies never saw its potentials!

-Big sigh-

[thechamp]

So bim is the soonest treatment

CB could have great potential for those that suffer from side effects with fin. It blocks conversion of Testosterone to DHT but if it gets absorbed in to the blood it immediately breaks down into inactive metabolites.

The problem is, it is set for release in 2017 which is so long away! By then most of us will be either just shaving our heads or have gone down the path of Histogen + Aderans to fix things up!

It's a shame that this drug could have been released by 2002 but pharmaceutical companies never saw its potentials!

-Big sigh-

realistically bim is the soonest treatment that will be ready!

[Desmond84]

Here's the timeline both for Acne & Hair loss:

http://www.cosmopharmaceuticals.com/~/media/Files/C/Cosmo-Pharmaceuticals/120502_pipeline_slide.pdf

CB-01-03 for Acne looks to be approved by first half of 2016 and for Hair loss by first half of 2017!

That's 4 years away

[Desmond84]

realistically bim is the soonest treatment that will be ready!

I really doubt bimatoprost would be a major improvement from Minoxidil.

Either way you will end up having to block DHT some how anyways!

[mmmcoffee]

Say these new treatments come out and they are much more effective than rogaine/fin...you obviously will use them over fin/rogaine and probably quit that combo of products.

Do we have any idea if any of these new treatments will keep your results from fin/minox, instead of most likely the huge shed that follows quitting a hair loss product

at least that was my experience when I naively quit rogaine for 3 months...i dont want to go through that again if I quit rogaine/fin for a new treatment

[thechamp]

So basically

So I will just have to use the big 3 for another 3 years unless a miracle cure comes out!

[Pate]

Des, CB is an androgen antagonist, not a DHT inhibitor. Which is even better because it blocks all androgens in the follicle.

Mmmcoffee, there should be no shed going from fin to CB, and probably no big shed going from minox to bin. They are just more effective versions. So it's like upgrading, not starting from scratch or switching drug types.

[mmmcoffee]

Des, CB is an androgen antagonist, not a DHT inhibitor. Which is even better because it blocks all androgens in the follicle.

Mmmcoffee, there should be no shed going from fin to CB, and probably no big shed going from minox to bin. They are just more effective versions. So it's like upgrading, not starting from scratch or switching drug types.

Pate, have you read that somewhere or is that a more or less guess? Only reason I ask is, I started using rogaine, then got on fin, and quit rogaine thinking they did the same thing, but since they dont, I went through a huge shed by quitting rogaine, even though I was on fin.

I know now they treat baldness in two clearly different ways so thats why I experienced the shedding that I did. But since its largely unknown why rogaine is effective (more or less) against MPB, maybe Bim treats it differently...i.e. another shed?

I dont mean to put yet another fear into peoples heads, but its worth a discussion I think. Even if there is a shed from switching treatments, if the new stuff is more effective, your shed will come back and hopefully thicker/healthier

[Pate]

Pate, have you read that somewhere or is that a more or less guess? Only reason I ask is, I started using rogaine, then got on fin, and quit rogaine thinking they did the same thing, but since they dont, I went through a huge shed by quitting rogaine, even though I was on fin.

I know now they treat baldness in two clearly different ways so thats why I experienced the shedding that I did. But since its largely unknown why rogaine is effective (more or less) against MPB, maybe Bim treats it differently...i.e. another shed?

I dont mean to put yet another fear into peoples heads, but its worth a discussion I think. Even if there is a shed from switching treatments, if the new stuff is more effective, your shed will come back and hopefully thicker/healthier

No I haven't read it anywhere. Nobody knows for sure. But it's the most likely outcome. Like you said the shed between minox and fin is because they have completely different mechanisms of action. Minox lengthens the anagen phase, probably via some sort of PG stimulation. Bim should do the same but more strongly.

Likewise CB should inhibit androgens more strongly than fin.

You may still get a shed from going on CB or bim but only the same sort of shed someone who isn't on anything would get. It shouldn't happen like going from minox to fin where you lose the effects of one when you start the other.

But it's all speculation at this point.

[Tracy C]

I wish we could have minox and RU in one topical.

If we could assume RU actually works and is safe to use, which we can't, that would be a reasonably good formula.

When I was trying to find reasonably good evidence for RU, I found a Youtube video of a young fella mixing up his own RU in bottle of propylene glycol. As I watched that video I was thinking to myself "Why doesn't he just mix it in with liquid Minoxidil?"... BTW, The young fella in that video does not even have MPB - and his before and after pics look exactly the same. There is absolutely no visible improvement - because he didn't even have MPB to begin with.

[hellouser]

If we could assume RU actually works and is safe to use, which we can't, that would be a reasonably good formula.

When I was trying to find reasonably good evidence for RU, I found a Youtube video of a young fella mixing up his own RU in bottle of propylene glycol. As I watched that video I was thinking to myself "Why doesn't he just mix it in with liquid Minoxidil?"... BTW, The young fella in that video does not even have MPB - and his before and after pics look exactly the same. There is absolutely no visible improvement - because he didn't even have MPB to begin with.

Mixing RU with PG isnt going to desolve it, its no wonder you dont believe it works even though IrishPride86 has well documented his use of RU with great results after mixing it with 95% alcohol.

I think you first need to learn how its applied before suggesting to the members of this forum that it doesnt work. Youre doing a great disservice to everyone interested in RU.

[Tracy C]

Youre doing a great disservice to everyone interested in RU.

I did not suggest that it does not work. I suggested that there is no good proof that it works, which is 100% true. What "proof" you can find is far from good. The safety has not been adequately proven either. Those who are truly doing a disservice are all those guys who don't even have MPB yet they are touting about how RU is working wonders for them. That is the true disservice.

If you want good proof that something works to treat MPB, you need to start with study participants who actually have MPB. I found lots of guys who are using RU. Not a single one of them actually has MPB.

[neversaynever]

I did not suggest that it does not work. I suggested that there is no good proof that it works, which is 100% true. What "proof" you can find is far from good. The safety has not been adequately proven either. Those who are truly doing a disservice are all those guys who don't even have MPB yet they are touting about how RU is working wonders for them. That is the true disservice.

If you want good proof that something works to treat MPB, you need to start with study participants who actually have MPB. I found lots of guys who are using RU. Not a single one of them actually has MPB.

Youre totally right. But i do have mpb and RU works. Shedding and the dreaded itch pretty much stopped within days. Safety, who knows. Nothing bad reported yet, in all these years. Except for the usual fin like sides from some people.

There will never be a study or trial with RU. Its dead.

I would drop RU in a heartbeat for a working PGd2 blocker. The lab rats need to hurry up.

I think RU being an 'experimental' drug, it might be unethical to reccomend it to others. I would say it works, but it is experimental, so you use it at your own risk.