Histogen at the ISHRS conference

[hellouser]

u've never gotten laid, have u?

Wow kid, you got me there.

Though your response does indicate you've never had a corporate job, lol. Tell you what; get a desk job and climb the corporate ladder. When you do that, come back and tell us what brand strategies and press releases look like as well as how much time is spent on preparing them, what decisions are made, how many people are involved, how many phone calls are made, how many boardroom meetings are held, how many conference calls go through, how presentations are made to investors, what information is made present to investors, what feedback is implemented from investors, etc.

You think this shit is as easy as going to your local camera shop, grabbing a point and shoot, taking a picture in auto and calling it a day? Well guess what dipshit, thats been done before and when it has the same kind of whiny dolts such as yourself were bitching about the inaccuracy of the photos showing all the information. Which is why I've posted many responses at length detailing the work involved in dead accurate and consistent photography (click here). So even if pictures were provided, do you know whats required to get the same results from before and after (I say this because you probably didnt read the in the link I posted earlier in this reply).

You really do seem to think everything is a 5 minute job without even taking into consideration the possible repercussions. Like I said, you've clearly never had a corporate job.

Take a seat kid.

[Kiwi]

lots of bald men make excuses for this company. they live in fantasy land cuz they dream of growing hair one day and believe everything this company says. so of course frustrated bald guys will make excuses, even if the company shows little or no hair growth.

my advice for Kiwi (not very bright) is to stop being so desperate. they promised pics in feb. so far were close to march.. duh

Dude. You're exceptionally thick and very naive.

I've been observing this site, histogen, aderans, replicel and all the others that have come and gone bust for about 5 years now. In the 5 years I've been obsessively studying... histogen and aderans are your best bet of getting your hair back thus far.

Dont get me wrong. I'm ready for them to fail. If they do I'm going to get SMP in Milan and shave my head.

I hope you've got a plan too

[goingquick]

u wouldnt **** me??!! whats kind of gay homo sh'it talk is that?? look homo, get ur gay ass out of here. we dont need any gay perverts here or anywhere. i'm reporting ur gay ass now.

You're reporting him for being...gay? What decade do you live in?

[koolx]

lol - I was just thinking the same thing.

They have no choice but to line up all their ducks and then announce properly with as many questions answered as possible.

Think about it. If they just take some random "snap" they instantly open themselves up to hundreds of angry balding people like us demanding answers to dumb questions.

My advice to koolx (not so cool) is to be patient. I HATE it. I REALLLY HATE IT AND I'M SO ANGRY WITH THEM.... but there is no other way. They are on our side.

lots of bald men make excuses for this company. they live in fantasy land cuz they dream of growing hair one day and believe everything this company says. so of course frustrated bald guys will make excuses, even if the company shows little or no hair growth.

my advice for Kiwi (not very bright) is to stop being so desperate. they promised pics in feb. so far were close to march.. duh

[Kiwi]

You've never had a corporate job, have you?

lol - I was just thinking the same thing.

Everything these guys do needs to be considered. They just cant do what you want them to do. EVERYTHING they do / show / say is going to be scrutinised by their investors, by people at the FDA, by people like us...

They have no choice but to line up all their ducks and then announce properly with as many questions answered as possible.

Think about it. If they just take some random "snap" they instantly open themselves up to hundreds of angry balding people like us demanding answers to dumb questions.

My advice to koolx (not so cool) is to be patient. I HATE it. I REALLLY HATE IT AND I'M SO ANGRY WITH THEM.... but there is no other way. They are on our side.

If you goto histogen.com and actually read what they said in their last announcement they talk about cosmetic results. Lets wait and see those results and hope they blow our socks off.

[hellouser]

come on.. stop pu'ssying around. pics are pics. a pic shouldnt have to be "prepared" to show how effective the drug is. if the drug grows adequate hair growth then any pic would show that no matter what. stop making excuses for the company.

You've never had a corporate job, have you?

[koolx]

There actually is a process for this, believe it or not, lol. I did photography a couple of weeks ago for an exhibition. I had around 800 photos and the bosses wanted to about 50-150 photographs in the end to upload for the public. However, I had to first weed out the bad ones and then present the good ones. They then pick out the ones they like and I need to do edits (colour correction, sharpening, etc) so all photographs look consistent and proper. The bosses the look at the photos and give the final go ahead and will often times ask for changes.

come on.. stop pu'ssying around. pics are pics. a pic shouldnt have to be "prepared" to show how effective the drug is. if the drug grows adequate hair growth then any pic would show that no matter what. stop making excuses for the company.

[Desmond84]

OK guys, here's a little summary of how clinical trials are conducted:

- Pre-clinical Phase: also known as "Proof of concept trials" and is conducted in Animals, Skin grafts, etc

- Phase 1: First in man trial. Aim is safety and pharmacokinetic data (~10-20 trial subjects)

- Phase 2: Examines safety & efficacy and is usually divided in TWO parts:

Phase 2a: is generally known as the "Dose-range finding study" and is conducted in about 50 patients. It examines dose-response relationships, frequency of dosing, and safety & efficacy of different doses, etc. This is how far Histogen has gotten btw.

Phase 2b: is known as the "pivotal trial", which is a rigorous study conducted in about 200-300 patients and examines the efficacy of specific doses & frequencies chosen from Phase 2a trial. It is generally longer than Phase 2a trials as well.

- Phase 3: is a large, blinded clinical trial conducted in around 2000-3000 patients and generates additional data on safety & efficacy. It generally lasts the same amount of time as Phase 2b trial (in this case 12-18 months).

So, we can say safely that considering Phase 2b and 3 each would take 14-18 months, Histogen is at least 3 years away from completing all of these trials. It will then require an additional 10 months to acquire FDA approval in US/Europe/Japan/Australia (i.e. Q1 2017). Hopefully though if all goes well, they might be able to release it in South Korea/Singapore 3 months after Phase 3 trial completion (i.e. Q1-2 2016).

Unfortunately, if they don't follow these specific model of trial design, most regulatory bodies would not even consider their application for approval and will require further studies to prove safety and efficacy.

[hellouser]

OMG! get the fu'ck out of here.. takes time to find the ideal pics... if u got to find the ideal pics, which doesnt and shouldnt exist, then this histogen is all bulls'hit.. listen everyone if it takes this much trouble for this company to supply a couple iof stupid little pics then dont waste your time.. this thing doesnt work.. look into other things.

There actually is a process for this, believe it or not, lol. I did photography a couple of weeks ago for an exhibition. I had around 800 photos and the bosses wanted to about 50-150 photographs in the end to upload for the public. However, I had to first weed out the bad ones and then present the good ones. They then pick out the ones they like and I need to do edits (colour correction, sharpening, etc) so all photographs look consistent and proper. The bosses the look at the photos and give the final go ahead and will often times ask for changes.

Now heres the thing;

This is all bullsh*t photography that doesnt have much if any effect on the company. What your asking for with the photographs is to open up a can of worms should the photographs reveal too much or not enough. A small company that doesnt rely on photographs wont be affected but for Histogen that photographic evidence has the potential to completely SCREW them has to be played safe. And you dont want to reveal your best photo either. Suppose you do but the final product doesnt work as great as what you presented? What do you do then?

[UK_]

OMG! get the fu'ck out of here.. takes time to find the ideal pics... if u got to find the ideal pics, which doesnt and shouldnt exist, then this histogen is all bulls'hit.. listen everyone if it takes this much trouble for this company to supply a couple iof stupid little pics then dont waste your time.. this thing doesnt work.. look into other things.

We're all ears...

[koolx]

I think it takes time to find the "ideal" pics for the public and potential investors. Furthermore, it takes also time to find the "ideal" success numbers (percentages) to these "ideal" pics.

OMG! get the fu'ck out of here.. takes time to find the ideal pics... if u got to find the ideal pics, which doesnt and shouldnt exist, then this histogen is all bulls'hit.. listen everyone if it takes this much trouble for this company to supply a couple iof stupid little pics then dont waste your time.. this thing doesnt work.. look into other things.

[UK_]

2000 USD every two years is pretty expensive.

concerning the number of injections and dose - nobody can tell, because phase II/III is supposed to check that.

Something like HSC, that bald people in the whole world will be depended on, so they can still hold their hair, shouldn't be expensive. because every bald guy will get the treatment every two years, an income from every bald guy in the world every two years will make histogen rich enough...
that 2000 price will make histogen bankrupt.. lol

anyway.. if that's the max amount of price that would be, it will drop eventually.

2000USD isnt expensive if you're spending that already on 2 years worth of supply of finasteride, minoxidil and the host of other snake oils everyone falls prey to each year.

[534623]

ok they said they'd update us this month with pics from the 12-month trial. so far i havent seen any pics. its almost march already.. where the hell are the pics??

I think it takes time to find the "ideal" pics for the public and potential investors. Furthermore, it takes also time to find the "ideal" success numbers (percentages) to these "ideal" pics.

[koolx]

ok they said they'd update us this month with pics from the 12-month trial. so far i havent seen any pics. its almost march already.. where the hell are the pics??

[HARIRI]

Thanks Desmond.

What's the reason for a phase IIB?

It really pisses me off when I hear Phase IIB, I have no clue why Histogen wants to prolong the trial II phase??? I never heard of this before. This means another delayed year for IIB results which makes it in total 2 years with Phase III !!! I hope Desmond84 enlighten us on it.

I only have strong hopes in Histogen, weak ones in Aderans and very weak ones in Replicel.