Histogen at the ISHRS conference

[Pate]

Hey guys,

First of all, merry xmas to all my balding brothers wishing u all the very best.

Secondly, koolx I've attached a copy of the trial in the link below for you to look at. I think your confusion comes from the fact that you're not aware of the number of injections they used. This was merely a safety trial (Phase I/IIa). So they only injected each patient with 8 injections at 3mm apart. Now, in order for you to notice significant cosmetic growth on the top of your scalp, they need to inject 200-300 injections!

Now I promise you they will eventually reach a point where they will inject the whole scalp (Phase IIb) and by the look of things, the results will be impressive. Just be patient and don't attack anyone on the forum! We're all here to help each other get through this curse

Peach brother

http://clinicaltrials.gov/ct2/show/N...istogen&rank=1

Des, the 8 injections were for the Phase IIb trial, the macroscopic photos were from Ziering's IND trial and there were 20 of them.

Still would only cover less than a square inch.

The interesting thing is that for four of the patients, they expanded the trial to 40 injections. So the total treatment was 120 injections like this:

Baseline: 20 injections
6 weeks: 20 injections
12 weeks: 40 injections
18 weeks: 40 injections

Results were photographed at between 12 and 24 weeks. So basically in none of those photos would you expect to see good results because the HSC just hasn't had enough time to reach its full effect. It takes 12 months for that.

I've said this til I've sounded like a broken record, but there are so many trolling f-wits determined to depressed people already struggling with their hair loss by destroying whatever hope they have left, so I'll say it again.

Until we see the results at 12 months, like a HT, we won't know what the full cosmetic effect will be.

On the other hand, if they show us results at 12 months that don't look any better than what they've already shown us, then yes, we may have a problem... That's when I'll listen to the nay-saying f-wits, not before.

[Desmond84]

Oh really! Fair enough Can't wait for the results man! I have a feeling it'll be good...

You know what's really strange? Our generation has only Aderans, Replicel & Histogen left in the game. If these guys don't make it then we're pretty much screwed! Everything else is at least 10 years away

So I don't know why so many ppl are rooting for these treatments to fail!!!

Talk about giving up and taking the world down with you!

[Artista]

Its called 'pessimism' Desmond, due to long term internal sadness and disappointments-realistically and unrealistically

[Scientalk56]

Des, the 8 injections were for the Phase IIb trial, the macroscopic photos were from Ziering's IND trial and there were 20 of them.

Still would only cover less than a square inch.

The interesting thing is that for four of the patients, they expanded the trial to 40 injections. So the total treatment was 120 injections like this:

Baseline: 20 injections
6 weeks: 20 injections
12 weeks: 40 injections
18 weeks: 40 injections

Results were photographed at between 12 and 24 weeks. So basically in none of those photos would you expect to see good results because the HSC just hasn't had enough time to reach its full effect. It takes 12 months for that.

I've said this til I've sounded like a broken record, but there are so many trolling f-wits determined to depressed people already struggling with their hair loss by destroying whatever hope they have left, so I'll say it again.

Until we see the results at 12 months, like a HT, we won't know what the full cosmetic effect will be.

On the other hand, if they show us results at 12 months that don't look any better than what they've already shown us, then yes, we may have a problem... That's when I'll listen to the nay-saying f-wits, not before.

about the photos thing,

Both Histogen and Zerinig showed us photos.
SID - they showed the "before after" photos from Ziering clinical trials - 3 months after injection in female patients in USA.

ISHRS - my questino is - what photos did they show us? from histogen or ziering trial?

Are there any photos from the trial in philippines???

[neversaynever]

about the photos thing,

Both Histogen and Zerinig showed us photos.
SID - they showed the "before after" photos from Ziering clinical trials - 3 months after injection in female patients in USA.

ISHRS - my questino is - what photos did they show us? from histogen or ziering trial?

Are there any photos from the trial in philippines???

someone should take the time to post all the photos histogen have made available. I have a feeling I've missed some.

[Desmond84]

Its called 'pessimism' Desmond, due to long term internal sadness and disappointments-realistically and unrealistically

Uhhh you know as cheesy as Rocky might be, there's scene near the end that really changed my life. Here it is if you wanna watch it:

https://www.youtube.com/watch?v=0dKmgPMDnCI&feature=endscreen&NR=1

Life's not all sunshine and rainbows! its a mean and nasty place and if you let it, it will kick you down and keep you there permanently!

It ain't about how hard you can hit, but how hard you can get hit and keep moving forward!

Believe it or not I used to be really depressed about my hairloss! But then one day I just decided to do everything I can to make things better and believe it or not I'm much happier now than I used to be!

I guess what I'm trying to say is there's no point being a pessimist, you just waste your life away being angry and pissed off; HOPE alone gets me through everyday...maybe it'll help you get through it as well...

Just saying...hope that helps

[Artista]

I feel the same as you Des' ..There is no point in allowing disappointments to keep you down.

[neversaynever]

Uhhh you know as cheesy as Rocky might be, there's scene near the end that really changed my life. Here it is if you wanna watch it:

https://www.youtube.com/watch?v=0dKmgPMDnCI&feature=endscreen&NR=1

Life's not all sunshine and rainbows! its a mean and nasty place and if you let it, it will kick you down and keep you there permanently!

It ain't about how hard you can hit, but how hard you can get hit and keep moving forward!

Believe it or not I used to be really depressed about my hairloss! But then one day I just decided to do everything I can to make things better and believe it or not I'm much happier now than I used to be!

I guess what I'm trying to say is there's no point being a pessimist, you just waste your life away being angry and pissed off; HOPE alone gets me through everyday...maybe it'll help you get through it as well...

Just saying...hope that helps

Id say there are alot of depressed guys on the forum, and they dont even know it. Maybe I am too, but I have things in my life that help me get perspective about hairloss.

Keep the positive vibes up, its needed.

Im very hopeful over histogen, but slightly suspicious from the photos I've seen. Maybe ive not seen some photos you guys have...

[Desmond84]

Im very hopeful over histogen, but slightly suspicious from the photos I've seen. Maybe ive not seen some photos you guys have...

Here's a few They look very promising

http://imgur.com/a/62ISJ

http://imgur.com/a/7GI4A

http://imgur.com/a/7BVb9

[neversaynever]

Here's a few They look very promising

http://imgur.com/a/62ISJ

http://imgur.com/a/7GI4A

http://imgur.com/a/7BVb9

There is some promise there. But two things strike me:

1. The difference in lighting
2. Both females

The huge positive is that only small areas were treated. So all we can do is stay positive and hope that they move into phase 3 and will release early in Asia.

[Scientalk56]

http://imgur.com/a/7BVb9#8mjvQ

the growth in this photo is incredible. and by the way this is a black man in his 50's if i'm not mistaken. I think it will have better results in younger men, with NW1-3.. especially with more injections and the potential to grow hair in temples.
i don't know why people here are disappointed.

i just wish that the next phase will have more participants. it should have 300 men. not 50. this number is a joke.

[Scientalk56]

Histogen - Safety Issues, Adverse Effects

another thing that concerns me:

Fen-phen made it to Phase III and many people lost their lives (or shortened them). The Histogen trial pool was also very limited to a small sample size and only two year follow up. Most oncology epigenetic related dynamical processes take five or more years to show up.

You can find this comment here:

http://forum.hishairclinic.com/topic/if-you-are-also-interested-in-histogen-read-here#.UNiUaG9J6dw

I also asked a dermatologist about histogen, and he said to me that a trial like that have to contain more participants. (300 people at least!!)

Histogen did phase 1 with 20 people and phase 2 with 50 people..
:S

[2020]

this thread is such a rollercoaster between soon having a cure and to everything is hopeless. As far I'm concerned, Aderans and Replicel are finished. Don't expect anything from them. They don't have anything now nor will they have anything in the future.
desmond was right when he said that those were our only hopes in the next 10+ years. Take away those two, and you're only left with Histogen who has shown poor results at this point however you want to spin it. They had more than 5 years to figure out this crap and up to this point they got nothing.

also, to the person who thinks that "regrowing" follicles is as difficult as regrowing heart then wow he doesn't know jack and judging how Aderans and Replicel describe their "science" they don't know it either. Follicles "regenerate" with each cycle automatically. Anagen -> Miniaturized follicle -> Anagen again. The problem is with activation and missing growth factors required to grow visible/normal hair.

[Benzzro]

this thread is such a rollercoaster between soon having a cure and to everything is hopeless. As far I'm concerned, Aderans and Replicel are finished. Don't expect anything from them. They don't have anything now nor will they have anything in the future.
desmond was right when he said that those were our only hopes in the next 10+ years. Take away those two, and you're only left with Histogen who has shown poor results at this point however you want to spin it. They had more than 5 years to figure out this crap and up to this point they got nothing.

also, to the person who thinks that "regrowing" follicles is as difficult as regrowing heart then wow he doesn't know jack and judging how Aderans and Replicel describe their "science" they don't know it either. Follicles "regenerate" with each cycle automatically. Anagen -> Miniaturized follicle -> Anagen again. The problem is with activation and missing growth factors required to grow visible/normal hair.

Weren't you the guy that said Replicel was the future? And everything else was useless?

[john2399]

this thread is such a rollercoaster between soon having a cure and to everything is hopeless. As far I'm concerned, Aderans and Replicel are finished. Don't expect anything from them. They don't have anything now nor will they have anything in the future.
desmond was right when he said that those were our only hopes in the next 10+ years. Take away those two, and you're only left with Histogen who has shown poor results at this point however you want to spin it. They had more than 5 years to figure out this crap and up to this point they got nothing.

also, to the person who thinks that "regrowing" follicles is as difficult as regrowing heart then wow he doesn't know jack and judging how Aderans and Replicel describe their "science" they don't know it either. Follicles "regenerate" with each cycle automatically. Anagen -> Miniaturized follicle -> Anagen again. The problem is with activation and missing growth factors required to grow visible/normal hair.

what the hell 2020, i thought you were pro histogen.