New Stemcell Treatment Photos... wow?

[garethbale]

534623

Why don't you respond properly if you are trying to contradict Dr Nigam...ie something along the lines of 'dr X's studies suggest that body hair does not grow longer on the scalp' rather than needless and rude replies.

[534623]

...ie something along the lines of 'dr X's studies suggest that body hair does not grow longer on the scalp' rather than needless and rude replies.

The names of these "dr X's" - ARE in the pics. Why should I mention their names in addition?? Or is it difficult for you to find out "who said what - and where?"

[garethbale]

The names of these "dr X's" - ARE in the pics. Why should I mention their names in addition?? Or is it difficult for you to find out "who said what - and where?"

what on earth are you on about now?

it's clear that my post is not disputing what you are saying, just the way you say it.

[One]

Dr Nigam can you make a public announcement here, saying: "within X months I to publish scientific proofs"

We are tired of your words on this forum without something scientific!

[didi]

dr nigam

i have about 40 pounds of fat i wanna get rid off, since you are an expert in the field can you tell me how much would your treatment cost, how much you charge per pound?
im serious about this, its as important as my hair.

im sick of al this lard, what do you suggest

[bananana]

I think neversaynevers question is very interesting. PGD2 and its role, it should definitely be looked into. Maybe that is preventing from getting even better results.

Keep up the good work dr Nigam and keep developing your technique.

[clandestine]

Dr Nigam today someone wrote this feedback about yourself:

-----------
Dr Nigam clining advanced stem cell therapy for Hair is completely fraud.I paid 2 lakhs for the stem cell and do not see anything good out of the treatment after 5 months
Instead of pure stem cell they are mixing with the treatrment FUT and charging unnecessary for stem cell
Staff are of poor quality and they are more like a money making machine

http://www.mouthshut.com/review/Dr-Nigam-s-Slimming-Centre-Mumbai-Health-Clubs-Fitness-Parlours-review-qsmtmmrqor

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What do you say about it?

This needs to be reiterated.

[neversaynever]

This needs to be reiterated.

Yes it does.

And I want to reiterate my previous question, whilst adding:

If balding men have elevated levels of PGD2, and PGD2 can indeed block certain signals which prevent stem cells from becoming progenitor cells:

Is it also possible that the elevated PGD2 levels also block another signal. When cultured cells are injected, and inducted by a follicle, Im assuming the cells of the follicle (or perhaps the cultured cells) send signals to 'join up'. So would PGD2 not also hinder that signal thus reducing the number of new cells recruited (or perhaps blocking entirely) and also prevent activation via something like Histogens HSC by inhibiting the positive activity of the stem cells. This might explain Aderans, Repicel, and Histogen results thus far, and maybe explain why results are mostly on areas of thinning hair or very recently slick bald.

?

[drnigams]

Didi,thanx for a change...
Not all the characteristics of a hair follicle are controlled by it's genetics,but also by the surrounding skin tissue.A nonwavy follicle transplanted from the back of the scalp to the mid scalp will become wavy if the original follicles of the recipient scalp were wavy.Similarly follicles from the chest or leg grows more in length and diameter when transplanted to the frontal or mid scalp.But definitely not as thick and long as scalp follicles.
Since body hair are single follicle ,hence a good option for making the hairline dense.
BHT is also a good option with people with wavy hair totally or partially.

do body hairs grow as body hairs or they grow as scalp hair once on scalp?

[clandestine]

Dr. Nigam;

Stop being selective about which questions you choose to answer. You're avoidance of hard questions does not lend you any cedibility; something which you desperately require at this point.

Answer mine and neversaynever's questions.

[drnigams]

Neversay,
The first step in the formation of a hairfollicle in an embryo is to reduce adherance among undifferentiated stemcells in the epithelial layer of the embryo.
Once the adhesion between stemcells is reduced ,it can become independent of underlying cells and start differentiating into a hair follicle,by becoming an epithelial bud as the first step before elongating towards mesenchymal layer.
This reduction in adherence is majorly achieved by wnt protein stimulation of a nuclear protein of stemcells called LEF1 through beta catinine protien and noggin protien signal from underlying mesenchymal cells.
The second coordinated signal is from proteins like HEDGEHOG,FIBROBLAST GROWTH FACTOR, BMP and few other proteins.
This is the present understanding of formation of a hair follicle in an human embryo.
Now in case of an anagen follicle which has regressed to a telogen Follicle the problem in getting it back to anagen phase is not just restricted to PGD2 inhibitory effect on the bulge stemcells or hair follicle cells.There is fibrosis around root of the follicle,there is reduced blood supply,there is reduced innnervation at the root and bulge stemcells.
There is no conclusive proof that bulge stemcells are prevented from becoming progenitor cells by PGD2 inhibitory effect.At present it is only presumed by costaralis (don't forget he works for a pharma company who plans to launch topical PGD2 lotion)/
PGD2 elevation around regressing follicle seen by costaralis is not a primary effect in itself to supposedly inhibit hair follicle,but PGD2 concentration is increased around regressing follicle as a secondary phenomenon which is not known to me ,but we know that PGD2 is secreted from MAST cells in response to allergens etc.As costaralis mentions he found mast cells and lymphocytes around hairfollicle and bulge stemcells ,which could be a secondary phenomenon to regression of hair follicle or inactivation of bulge stemcells.
At present i will need more concrete evidence to focus on blocking PGD2 to improve my HM results.Let the specific topical solution be made available by the pharma company ,probably than i may experiment in vitro in the lab first,although your reference link claims that PGD2 inhibited follicle culture growth in vitro.
As on today my major focus is to directly inject progenitor stemcells into dormanting follicles,since there exists atleast a follicular structure.I am waiting to receive my order from USA of wnt protien,HEDGEHOG protien and few other growth factors.If DHT was the prime reason for hairloss ,replenishing the hair follicle receptors with anti DHT i.e finisteride would have cured baldness by now.

Thank you, that is one of your better replies.

What are your thoughts on something 'blocking' cultured DP cells from communicating with the stem cells to start hair growth?

Is it possible that PGD2 could be blocking this process?

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

Please refer to the link. It shows PGD2 inhibits hair growth. There are other studies that indicate PGD2 can inhibit 'cell talk'. We know somewhere lower down the ladder DHT plays a big role, which goes on to alter TGF's and BMPs in the hair follicle, and maybe finally, producing too much PGD2.

PGD2 has been a huge talking point on the forums since the study and its finding were made public. Other studies have shown the following:

Earlier studies about cell lines found that micromolar amounts of the PGD2 metabolites inhibit cellular proliferation

Perhaps this (or something similar) is the reason why cell based hair therapies can yield great results on mice, but not in a human balding scalp. The cells that you, aderans, replicel inject are recruited by the follicle but the PGD2 (or something else) that surrounds the follicle is still preventing the cross talk between the DP cells and the bulge stem cells.

Therefore, are you interested in PGd2 therapies? Do you have any knowledge you can add? Do you think a cell based treatment combined with PGD2 treatment might yield better results?

I believe PGD2 also inhibits the migration of Langerhans cells in the follicle. Maybe we could skip all the process and inject all the signals the stem cell requires to produce hair, but PGd2 blocking might be available soon.

Is it possible to monitor the movement of cultured cells in vitro with a balding hair follicle? If yes, what are your thoughts on also testing a PGD2 blocker in vitro, and then followed by the addition of cultured cells?

If, as a few studies have indicated, pgd2 and its evil son pgj2 inhibit proliferation of the stem cells, then I think it should be of great interest to you...

Bottom line is: We still dont know enough to get the cells talking again, though maybe Histogen have got us closer. A popular study has also shown that bald scalps still have the required stem cells. But perhaps the increased PGD2 in balding follicles is preventing aderans, you, repicel, histogen from achieving remarkable results?

Instead of focusing on what the signals the stem needs, maybe you should focusing on what is blocking that signal (might be easier), and then combine cell therapy with a therapy that inhibits the agent that is blocking the DP to stem cell signal.

Sorry for the amatuer questions again, I'm just a curious person, and interested in your technical thoughts.

[drnigams]

The person in the concerned link has been forwarded my mail address to discuss further on his follow up status.If he is a genuine patient he will revert back and we will try to analyze the results and accordingly take further corrective measure.Although i am surprised he did not once contact us to discuss the matter,there are many competitors to post such remarks.This is the first patient who claims to have had our treatment and not satisfied,although others who have commented against us in the past have never claimed to have taken our treatment.
Have just replied to neversay.

Dr. Nigam;

Stop being selective about which questions you choose to answer. You're avoidance of hard questions does not lend you any cedibility; something which you desperately require at this point.

Answer mine and neversaynever's questions.

[neversaynever]

Thank you for the replies Dr Nigam, it is appreciated.

I must disagree about one aspect of your DHT statement. While it might not be the ONLY cause of male pattern baldness, fin and other anti-dht chemicals can save your hair, and do so for many people. The problem is the half life of these compounds means you need daily consumption. Therefore, washing a follicles receptors with anti-dht treatment will only provide a temporary solution, until that compound disapears. If an anti-dht compound lasted for months at a time, then those in early balding might well be 'cured'.

Of course, there are many many other factors once a follicle is dormant.

Male pattern baldness shares alot in its mechanism to something like acne, would you agree? If so, DHT and PGD2 will indeed play a big role.

I do believe there is a connection between PGD2 and stem cell proliferation. Specifically, proliferation of the hair stem cells. But as you stated, there is no concrete proof.

You activate stem cells, which become progenitor, and you then inject them. Earlier you said "you do not question why Gho keeps follicles in a preservation medium". Gho was debated for a long long time on these forums before people started to believe in it...

But what he does is different. What I cant understand is why there would be any benefit from using the cells of just 100 follicles? Its such a lower number that surely they would serve better for multiplication purposes? Or perhaps my body hair idea suggested on the other forum...

Using the cells from 2000 body hair follicles, activate them, and then inject...do you see any reason why that would not work? I think youve stated also that beard hair is preferable, can you please state the exact reasons for that? Why are the cells in beard hair better to use than in other hairs?

Also how do you inject? A standard needle? Mesotherapy gun? A tool that you designed?

What are you throughts on recent findings that state cultured hair cells perform better when implanted, if they were stored with a certain type of vitamin D? Here is part of the study....

http://www.ncbi.nlm.nih.gov/pubmed/23197867

Here is a silly question...

If you culture cells, and store them in a petri dish. Then extract a balding follicle, bath it in the new cells, and re-implant the follicle form where you took it, would there be any benefit?

Would it also not benefit to inject culture cells, and then inject with wnt, bmps, and other positive signals? Would that cause health risks?

Lots of questions, again. Hope you can answer.

[drnigams]

Please read point 4 and 5 ,which also mention that body hair when transplanted into the scalp grow in length more than their body length. Remember genetics of a hair follicle is not the only factor but the surrounding skin tissue also plays a role in the defining of character and length of a hair follicle,You mean to say older surgeons are better than younger ones..!With due respect ,each one is unique and age has its advantages as well as limitaions.

https://vimeo.com/52530963






All these guys are much longer than you in the HT business and they are doing BHT since around 10 years. So I think they know more than you ...

[didi]

dr nigam

do you know wtf is going on with your Hm, everyones so confused

you been preaching abt your HM for the past 3 months but no credible evidence yet, only complaints, dr nigam this dr nigam that...


no results, no goodies