Aspirin would actually be your best bet (SARCASM). However, not sure how this would pan out. Hopefully, the side effects would stay topically. Other drugs that would act at the top enzyme in the chart below include all the NSAID drugs such as ibuprofen.
However, I wouldn't use aspirin, just because you need the other prostaglandins to function properly. Also, increased intake of aspirin or any other non steroidal antiinflammatory increases the risk for gastric ulcers.

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