Cetirizine

[thechamp]

Doke

Where you buy propylene glycol from?

[doke]

also bought some distilled water and propylene glycol for the mix.

[doke]

got enough to last years hahaha

[thechamp]

Good work dole

Well done doke,there solid science behind this imagine if this works after all this trx2 bullshit we gave been threw!

[doke]

hi champ i have just ordered eight 30 10mg tablets of cetirizine and only cost me about six quid i see that you can buy liquid 10mg capsules of cet but it would be very expensive in benadryl allergy liquid release.

[thechamp]

Worth a shot doke

And this will be a topical something has to work lol

[doke]

I do not know if any guys here remember ken aka his rk19 product many years ago contained oral antihistamine plus a vit as well which caused a big internet argument as to a scam and some saying it worked.
And what about hydrocotisone which many say stopped the itch and i think some minoxidil on sale contains like promox.
But this may help with calming the scalp into some regrowth its worth a try and if its cheap then i may give it a go.

[thechamp]

Quote:
Originally Posted by garethbale
Hi Desmond

Can I just take zyrtec tablets orally then? It seems much easier than making a topical and I don't want to mix up everything into a solution. But if the topical is the best method I will try that. Thanks

I wanna try the topical but don't want to she'd to much as I'm a Norwood 1 and what's the chance of keeping my hair with this topical or growing it back?

[Pate]

Hi Desmond

Can I just take zyrtec tablets orally then? It seems much easier than making a topical and I don't want to mix up everything into a solution. But if the topical is the best method I will try that. Thanks

I think the issue with taking them orally is the dose. If you apply 10mg topically you will get a much higher dose to the scalp than if you take it orally where it will diffuse throughout your entire body.

You'd have to take a shed load of pills to get the same concentration in your scalp which would have systemic effects. So I think topical is the way to go.

One concern I have is we have no idea how much cet will go systemic from topical application. But I guess if you apply 10mg then no more than that can do systemic. Perhaps much less. I have no idea how much of a drug is typically going to go systemic from application to the scalp. I guess it varies widely.

Any thoughts Des?

[thechamp]

Agrered

Well five weeks till, I go on holiday thinking I have plenty if hair but if I start this treatment will I loose alot of hair or will I be able to keep it there's no gaurentee

[rdawg]

Hi Desmond

Can I just take zyrtec tablets orally then? It seems much easier than making a topical and I don't want to mix up everything into a solution. But if the topical is the best method I will try that. Thanks

Injesting it orally gives you more risk of side effects. I believe it gives the same benefit but less side effects if you use it topically.

EDIT: and On a side note I love how we're all becoming researchers right now. Screw the FDA trials!!(sarcasm kinda, I know they're for safety but still, 3-5 years is a long wait for hairloss!).

[garethbale]

Hi Desmond

Can I just take zyrtec tablets orally then? It seems much easier than making a topical and I don't want to mix up everything into a solution. But if the topical is the best method I will try that. Thanks

[thechamp]

Desmond

Desmond all this sounds to good to be true if we only knew years ago about this dam it lol!

[Desmond84]

Good News

Hey guys,

I thought it was really odd how Cetirizine had shown no effect on PGD2, particularly since Cetirizine is far more effective than Loratadine (Claratyne) & Fexofenadine (Telfast) when it comes to SKIN allergies.

So I did a lot of digging and found that within 5 hours of its oral use it inhibits PGD2 production in the skin by at least 50%!

I think the previous study was looking at PGD2 levels in nasal mucosa. I guess it makes sense. For example, antihistamines don't seem to work when you have a runny nose due to a cold (minimum effect on PGD2 in the nose) so we have to resort to Sudafed (Pseudoephedrine) to dry up and unblock our nose

Here's a study for you guys to look at. This was conducted during its approval process

http://www.ncbi.nlm.nih.gov/pubmed/2469708

So, stick to Cetirizine for now, until I dig up more info on Cromolyns.

P.S. If Cromolyns are more effective, there's a product called INTAL SPINCAPS, which are Cromolyn based capsules that go into a inhaler device. We can just open one capsule everynight, mix it with Emu oil & Propylene Glycol & voila

[ovoxo]

so maybe ethanol/ppg vehicle for loratadine?