Equol

[gutted]

Id rather take equol, at least until there is more progress with pgd2 and cox2 stuff. You may well be right, but there isnt any compound available at this point (thats known to maintain hair). Its another interesting avenue though.



Also, i dont see how an oral cox 2 suppressor is a good choice. If we took oral medicine strong enough to block cox 2 in the scalp, would that not be massively dangerous for us?

there have been various patents explaining how blocking these enzymes results in hair growth.
although i agree taking the more potent ones (benaxoprofen etc) can be dangerous but saw palmetto, msm, curcumin seem to be tolerated well.

also bear in mind im not saying these drugs need to be taken for life - only until regeneration takes place which will give you a 3/5 year anagen hair cycle until minturaisation takes course.

in my personal opinion blocking cox2 is one of the most underrated hair loss approaches.

using eqoul will allow you to maintain however blocking cox 2 directly will allow actual hair regeneration. It is this upregulated enzyme that stops hair from turning terminal

[2020]

using eqoul will allow you to maintain however blocking cox 2 directly will allow actual hair regeneration. It is this upregulated enzyme that stops hair from turning terminal

how is that even possible? Wouldn't castration automatically downregulate cox-2?

Did you find any shampoos that are good at blocking COX-2?

[gutted]

how is that even possible? Wouldn't castration automatically downregulate cox-2?

Did you find any shampoos that are good at blocking COX-2?

cox 2 expression stays upregulated permanently after the last hair cycle -> follicles go dormant.
the only way to revive those is through cox2/ (possibly 5lox as well) inhibition. Doing this forces the hair follicle to regenerate. Whether those hairs are cosmetically accepatable (thick) depends on the amount of cox2 that has been blocked at the point when the follicle decides to regenerate.


nizoral blocks cox2/5 lox, however it has other effects hence why i wouldnt reccomend it.

[2020]

cox 2 expression stays upregulated permanently after the last hair cycle -> follicles go dormant.

PERMANENT upregulation? How do you deregulate it forever? "switches" like that are bad news for Histogen

what are you taking currently?

[gutted]

well, semi permanently.

you cant deregulate it forever, its part of you. What needs to be done is inflammation controlled which elevates cox2 further more in addition to the natrual hair cycling cox2 expression through androgens.

trx2, msm, curcumin, garlic extrct, saw palmetto.

[2020]

well, semi permanently.

you cant deregulate it forever, its part of you. What needs to be done is inflammation controlled which elevates cox2 further more in addition to the natrual hair cycling cox2 expression through androgens.

trx2, msm, curcumin, garlic extrct, saw palmetto.

how could they miss such an obvious thing - inflammation.

Bad news just keep coming in.... if it turns out that MPB is caused by some "permanent switch" rather than some real damage than we're screwed.

I almost wish that MPB was auto-immune at this point.

[gutted]

how could they miss such an obvious thing - inflammation.

Bad news just keep coming in.... if it turns out that MPB is caused by some "permanent switch" rather than some real damage than we're screwed.

I almost wish that MPB was auto-immune at this point.

there is no "permanent switch". Its fully reversible with time.
Benaxoprofen proves this.

[2020]

there is no "permanent switch". Its fully reversible with time.
Benaxoprofen proves this.

perhaps? But how could Histogen POSSIBLY overcome this "semi-permanent" overexpressed COX-2 expression?

benaxoprofen is a suicide and it doesn't prove ALL of it since not many people in the experiment experienced the reversal of MPB.

Out of 300 patients who had taken benoxaprofen for a mean of 6.4 months, 196 (65.3&#37 reported side effects, resulting in 104 patients (34.6%) having the drug withdrawn.

also, the crap you're taking won't do much. You should at least try sulfazine which is like a "weaker" benaxoprofen with minimal side effects.

[gutted]

perhaps? But how could Histogen POSSIBLY overcome this "semi-permanent" overexpressed COX-2 expression?

benaxoprofen is a suicide and it doesn't prove ALL of it since not many people in the experiment experienced the reversal of MPB.




also, the crap you're taking won't do much. You should at least try sulfazine which is like a "weaker" benaxoprofen with minimal side effects.

why do you keep going on about histogen? histogen works long term through possibly many unknown mechanisms, (even possibly indirect downregulation of cox 2) and right know i would take hostogen over ANY "inconvenient" topical or drug.

yeh i know benaxoprofen is a suicide but the underlying principle needs to be researched further.

the "crap" im taking is without a doubt definiteley maintaing for me, as for regrowth, ill know more with time.
dont want to take sulfasalazine due to possible sides but full regrowth of a hairline = cure.

[2020]

why do you keep going on about histogen? histogen works long term through possibly many unknown mechanisms, (even possibly indirect downregulation of cox 2) and right know i would take hostogen over ANY "inconvenient" topical or drug.

because I've been researching their science for the past month and I don't think that HSC would work long term especially if there is some kind of "switch" rather than "damage" which I think is the case. Stem cells simply turn off so that's the main problem. HSC also claims that they grow BRAND NEW FOLLICLES.... yeah I don't think so

yeh i know benaxoprofen is a suicide but the underlying principle needs to be researched further.

it does!

the "crap" im taking is without a doubt definiteley maintaing for me, as for regrowth, ill know more with time.

and how do you know that's not due to TRX2 and saw palmetto where both have some positive studies so you certainly wouldn't be the first one to regrow hair on either one of those.

dont want to take sulfasalazine due to possible sides but full regrowth of a hairline = cure.

dude that drug has been around for like 50 years and millions of people take it for arthritis plus I'm sure you can get it for cheap nowadays. It's definitely safe.

This also comes back to: why aren't those millions of people on NSAIDS regrow any hair?

[JDW]

Is anyone on here getting that s-equol Folloxen product that's being talked about on ***?

[gutted]

and how do you know that's not due to TRX2 and saw palmetto where both have some positive studies so you certainly wouldn't be the first one to regrow hair on either one of those.

its difficult tell if youve regrown hair if your not fully bald. Leaving it to human vision to assess whether youve rergrown hair (unless you are slick bald) is very hard, although i believe i have regrown some hair on my regime although not where i would like it to grow. Hence why i want a guinea pig that is a slick bald nw5/7 to see what this can do on them.
Its not trx2 or saw palmetto alone, its definetley the combination, that is preventing me from further balding - 2000%

dude that drug has been around for like 50 years and millions of people take it for arthritis plus I'm sure you can get it for cheap nowadays. It's definitely safe.

Yeah i know but stil...you never know, i would have to stay on it for around a year or two and cant really commit to that.

This also comes back to: why aren't those millions of people on NSAIDS regrow any hair?

its very difficult to assess if you have regrown hair unless you are slick bald hence why its one of the reasons why people dont/cant take notice.
Also i doubt even if people noticed they regrew hair using it they would come on places like this to document it.

[yeahyeahyeah]

Is anyone on here getting that s-equol Folloxen product that's being talked about on ***?

I might order it.

[2020]

interesting... a bunch of people were regrowing hair left and right on hydrocortisone:

https://www.google.com/webhp#q=site:hairlosshelp.com hydrocortisone

http://en.wikipedia.org/wiki/Topical_steroid#Classification_systems

here's your cure:
http://en.wikipedia.org/wiki/Clobetasol_propionate (side effects: Hypertrichosis)

^ if this doesn't regrow you hair, nothing will


EDIT: RESULTS FROM CLOBETASOL PROPIONATE

before:


after:

[gutted]

interesting... a bunch of people were regrowing hair left and right on hydrocortisone:

https://www.google.com/webhp#q=site:hairlosshelp.com hydrocortisone

http://en.wikipedia.org/wiki/Topical_steroid#Classification_systems

here's your cure:
http://en.wikipedia.org/wiki/Clobetasol_propionate (side effects: Hypertrichosis)

^ if this doesn't regrow you hair, nothing will


EDIT: RESULTS FROM CLOBETASOL PROPIONATE

before:


after:

needhairasap, was supposed to be trialling this stuff, but i guess he probably didnt stick with it long enough to see any regrowth, dont know what the situation is with him though.