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If anyone is going to try this, please post a picture before starting treatment
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Clinical Pharmacology
Like other topical corticosteroids, betamethasone valerate foam has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.Comment
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I'm not sure if it doesn't say
this guy used a bunch of shit, but it may have been his use of an EGFr inhibitor (not sure which) that caused the amazing regrowth (pictures in the hyperlinked thread).
I think there is some connections between EGFr and PGD2
we have to figure out if these foams stop PGD2. I know that both foams that I mention in the opening post have side affects of excessive hair growth...Comment
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The comparison of treatment with clobetasol propionate 0.05% and topical pimecrolimus 1% treatment in the treatment of alopecia areata
Read More: http://informahealthcare.com/doi/abs...34.2011.590788
this journal has crazy photos.. the before after pics are mind boggling... you google if and use google images you can see.. unfortunately you have to pay for the real article.\
also, pimecrolimus is a PGD2 antagonist and has less side affects than cortisolsteroids like clobetasol and betamethowhatever
another PGD2 antagonist is cetuximab.. but i think its an intense cancer drug
I think pimecrollimus is the way to go. We should test this out. I'm not seeing it mentioned that it has hair growth as a side effectComment
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heres some more info - http://www.dermattikon.gr/magazines/...OULIS%20EN.pdf
i think its best to stick with the betamethasone valeratel.
we know hypertrichosis can be a side effect with that, with the rest of the stuff we're just guessing it could grow hair.Comment
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pimecrolimus works
The prolonged treatment with potent topical steroids deserves comment. Orentreich et al (4) reported the failure of local injections of corticosteroids to induce hair growth in 50 cases of male pattern alopecia. Topical corticosteroids were unsuccessful in 40 additional patients with various causes of alopecia (4). A restoration of the normal perifollicular vascular architecture accompanies both the spontaneous regrowth and corticosteroid-induced regrowth of hair in alopecia areata (5). It is possible that the prolonged use of a potent topical steroid induced a normalization of the vascular pattern, but this seems unlikely in view of the study of Orentreich et al (4).
Robert L. Rietschel, MD
David D. Madorsky, MD
Brooke Army Medical Center Fort Sam Houston, Tex
4. Orentreich N, Sturm HM, Weidman AI, et al: Local injection of steroids and hair growth in alopecias. Arch Dermatol 82:894-902, 1960.
5. Popchristov P, Konstantinov A, Obreshkova E: The blood vessels of the scalp in patients with alopecia areata before and after corticosteroid therapy. Br J Dermatol 80:753-757, 1968.
source:http://webcache.googleusercontent.co...&ct=clnk&gl=usComment
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what the hell?
Through the years, Mr. Murphy has always had an active interest in health and medicine, and he originally considered going to medical school. Instead, he decided to pursue his own specific interests, including nutritional supplements that he thought might help cure his early-stage androgenic alopecia. In 2008, after thousands of hours of research and development, he succeeded in creating a formula which halted his hair loss. After verification of his novel equol-producing formula from a third party laboratory, Mr. Murphy decided to turn his project into a business.
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