PGD2, betamethasone valeratel, and hair growth....

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  • 2020
    Senior Member
    • Jan 2012
    • 1513

    #61
    Originally posted by gutted
    its probably the ideal solution if you are 16-18, way better than fin to help keep your hormonal profile at opitiumum levels but you wont get any real regrowth from it.

    i think most people want major regrowth.
    so you're basically saying that equol stops male pattern baldness? I don't care about regrowth. Maintaining what I have now will be enough...

    wth, back in 2005 or so everyone was talking about it. Why did it die out?

    Comment

    • 2020
      Senior Member
      • Jan 2012
      • 1513

      #62
      Originally posted by gutted
      this is not an eqoul discussion!

      ant inflammatories are the next best thing.
      right I'm just disappointed at all those people who tried solving MPB 10 years ago... so many "unfinished" theories. Why can't we just make a list and then once we prove some theory false we just check it off or something

      Comment

      • gutted
        Senior Member
        • Jan 2011
        • 1397

        #63
        Originally posted by 2020
        so you're basically saying that equol stops male pattern baldness? I don't care about regrowth. Maintaining what I have now will be enough...

        wth, back in 2005 or so everyone was talking about it. Why did it die out?
        like i said, no one wants to waste time and hair on something thats not scientifically proven.

        Comment

        • NeedHairASAP
          Senior Member
          • Jul 2011
          • 1408

          #64
          Originally posted by gutted
          heres some more info - http://www.dermattikon.gr/magazines/...S%20EN.pdf

          i think its best to stick with the betamethasone valeratel.

          we know hypertrichosis can be a side effect with that, with the rest of the stuff we're just guessing it could grow hair.
          yes, betamethasone valeratel AND Clobetasol Propionate both have hypertrichosis as side effects


          beta has been included in minox,we know it grows hair and could be the reason minox grows hair


          but clobetasol has some AMAZING before/after pictures in that study I posted about AA and clobetasol and pimaminuuss-whatever


          it's a toss up between the two. I think beta is the safer steroid of the two but I don't know

          Comment

          • 2020
            Senior Member
            • Jan 2012
            • 1513

            #65
            Men with androgenic alopecia typically have higher levels of 5-alpha-reductase, lower levels of total testosterone, higher levels of unbound/free testosterone, and higher levels of total free androgens including DHT.[15][16]

            Sex hormone-binding globulin (SHBG), which is responsible for binding testosterone and preventing its bioavailability and conversion to DHT, is typically lower in individuals with high DHT.
            The aim of this study was to evaluate the effect of supplementing healthy men with soy isoflavones on the serum levels of sex hormones implicated in prostate cancer development. A total of 28 Japanese healthy volunteers (18 equol producers and 10 equol non-producers) between 30 and 59 years of age were given soy isoflavones (60 mg daily) supplements for 3 months, and the changes in their sex hormone levels were investigated at the baseline and after administration. The serum and urine concentrations of daidzein, genistein, and the levels of equol in the fasting blood samples and 24-h stored urine samples were also measured. All 28 volunteers completed the 3-month supplementation with isoflavone. No changes in the serum levels of estradiol and total testosterone were detected after 3-month supplementation. The serum levels of sex hormone-binding globulin significantly increased, and the serum levels of free testosterone and dihydrotestosterone (DHT) decreased significantly after 3-month supplementation. Among the 10 equol non-producers, equol became detectable in the serum of two healthy volunteers after 3-month supplementation. This study revealed that short-term administration of soy isoflavones stimulated the production of serum equol and decreased the serum DHT level in Japanese healthy volunteers. These results suggest the possibility of converting equol non-producers to producers by prolonged and consistent soy isoflavones consumption.
            WHY DID THIS THEORY DIE???

            Comment

            • NeedHairASAP
              Senior Member
              • Jul 2011
              • 1408

              #66
              Originally posted by 2020
              WHY DID THIS THEORY DIE???
              so were forgetting about pgd2 now and just eating lots of soy products??

              Comment

              • gutted
                Senior Member
                • Jan 2011
                • 1397

                #67
                Originally posted by 2020
                WHY DID THIS THEORY DIE???
                you should try it out.
                dht is no longer a problem for me.
                we should concentrate on cox 2/pgd2

                Comment

                • gutted
                  Senior Member
                  • Jan 2011
                  • 1397

                  #68
                  Originally posted by NeedHairASAP
                  yes, betamethasone valeratel AND Clobetasol Propionate both have hypertrichosis as side effects


                  beta has been included in minox,we know it grows hair and could be the reason minox grows hair


                  but clobetasol has some AMAZING before/after pictures in that study I posted about AA and clobetasol and pimaminuuss-whatever


                  it's a toss up between the two. I think beta is the safer steroid of the two but I don't know
                  what pictures?

                  Comment

                  • NeedHairASAP
                    Senior Member
                    • Jul 2011
                    • 1408

                    #69
                    Originally posted by gutted
                    what pictures?

                    before


                    after



                    from this study on clobetasol propionate and pimecrolimus

                    Comment

                    • NeedHairASAP
                      Senior Member
                      • Jul 2011
                      • 1408

                      #70
                      "Pimecrolimus is a macrolactam of the immunosuppressant class. It is a selective inhibitor of pro-inflammatory cytokines and mediators in T cells and mast cells." (source: some website)


                      mast cells produce PGD2


                      "Conclusion: In conclusion, we detected that topical pimecrolimus treatment is as effective as topical corticosteroids and is superior to topical corticosteroids in terms of side effects in the treatment of AA."

                      source: http://informahealthcare.com/doi/abs...34.2011.590788




                      thusly, we should use pimecrollimus

                      Comment

                      • gutted
                        Senior Member
                        • Jan 2011
                        • 1397

                        #71
                        Originally posted by NeedHairASAP
                        before


                        after



                        from this study on clobetasol propionate and pimecrolimus
                        thats some major regrowth!

                        id like to know how it works. its a topical corticosteroid
                        i think it surpresses the immune system.

                        Comment

                        • NeedHairASAP
                          Senior Member
                          • Jul 2011
                          • 1408

                          #72
                          Originally posted by gutted
                          thats some major regrowth!

                          id like to know how it works. its a topical corticosteroid
                          i think it surpresses the immune system.
                          it has to be some of the best regrowth ever recorded... not sure how people missed this... I guess it's because it happened before the immune system and PGD2 was implicated? in other words, it was when they thought AA was vastly different than MPB

                          Comment

                          • gutted
                            Senior Member
                            • Jan 2011
                            • 1397

                            #73
                            Originally posted by NeedHairASAP
                            it has to be some of the best regrowth ever recorded... not sure how people missed this... I guess it's because it happened before the immune system and PGD2 was implicated? in other words, it was when they thought AA was vastly different than MPB
                            yeah i agree.

                            Comment

                            • bigentries
                              Senior Member
                              • Dec 2011
                              • 465

                              #74
                              Originally posted by NeedHairASAP
                              before


                              after



                              from this study on clobetasol propionate and pimecrolimus
                              You got to be kidding me. They need to test that with MPB
                              A lot of people affected by AA end up cured spontaneously

                              Comment

                              • NeedHairASAP
                                Senior Member
                                • Jul 2011
                                • 1408

                                #75
                                Originally posted by bigentries
                                You got to be kidding me. They need to test that with MPB
                                A lot of people affected by AA end up cured spontaneously

                                I'm starting treatment now as I have some of the foam. Can anybody get ahold of the journal article? I'd like to know how often and how long the presecribed the use of the foam

                                Comment

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