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I had never watched the full 2010 A.R.I. presentation until now, thanks Desmond.
The video 'regenerates' my optimism for the NEAR future of us, the hair loss SUFFERERS.
I believe it very well just may be the "Next big GAME CHANGING platform" as it has been defined. I would not expect it to produce a juvenile head of hair but that it would do far greater ,percentage wise, than what is available today.
Personally and realistically , all i want to achieve is an IMPROVEMENT to my scalp. I would never expect to once again have the head of hair that i did at the age of 19. Although,, that would be an amazing experience.Comment
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Being able to modify and fabricate DHT resistant follicles would surely cause a hump in the HT business. Majority of patients suffering from androgenetic alopecia wouldn't need to resort to HT, and could solely be used for those individuals who were involved in a traumatic accident of some sort.
Also, secondly, if they could engineer it to make the receptors resistant at the level of the prostate - would completely solve this issue. Prostate cancer is the #1 cancer in males, but the 2nd leading cause of death in males, followed by lung cancer.Comment
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It's 1st of November and Histogen has provided us with a third round of updates with some amazing results. Aderans really needs to give us an update soon! I mean whats with all the secrecy!!!Comment
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Btw, I spoke to them this morning after noticing they're practically located on the same exit as to where I live. They're conducting studies all across the US. They plan on releasing a new study group in downtown Atlanta, GA. Person said to check this site for other studies, as they're always looking for candidates.
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JJ, during your conversation did they mention what Phase they were recruiting for? That would really be helpful if you could find out somehow. Thanks for taking the iniative to help look into this!Comment
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Joker, it shows to be Phase 2
I just called the Florida locale ,they have filled their enrollment quota . She also said that all the other Radiant Research, Inc locales have too .Comment
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Hi Artista, I know that the clinical trials page says Phase 2. Not sure if you've been following the thread (don't blame you if you haven't), but some sites have stated over the phone that they were actually recruiting for Phase 3. I'm just trying to reconcile these differing pieces of information. For example, when I called in Florida they told me it was a Phase 3 trial.Comment
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I unfortunately didn't ask that, as it slipped my mind. I'd like to join but I'm sure many probably wouldn't qualify as it would require John Doe to not have taken Rogaine in the past 6 months or fin in the past year. In addition, you can't use these treatments while getting the treatment. To add to the insult, if this were a double blind study, and you became part of the control group that's additional time without the supportive treatments, and would result in further hair loss.Comment
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PS: Winston, can Aderans have its own sub forum like Histogen?
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Hey guys, I've been thinking a lot about how Adernas works and had a few questions that some of you guys might know the answer to:
So far, what I've understood is Aderans takes samples of Dermal & Epidemal cells from the back of your scalp, replicates them (by millions) and injects them in the frontal scalp. Now, here's my questions:
"How do they know that DHT receptors that get expressed on hair follicles in ppl with AGA are only present on these specific cells and not on other parts of the follicular unit? In other words, will the new follicles become DHT-Resistant in true sense of the word?"
"Also, another question is when they inject these cells into your scalp, you already have dermal and epidermal cells surrounding that follicle, so what makes the old ones disappear and the ones Aderans produced replace them?"
It just doesnt make sense to me, so I thought I would share...Comment
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Alright everyone, so since no one in the media seems to be helping us out in getting info from Aderans, I did a little bit more research tonight.
I compared the clinical trial arms listed on clinicaltrials.gov with the ones listed in their June 2010 powerpoint. As a result, I learned some interesting things.
First Phase 2 Test
CA-2011 Ji Gami (enrollment 21, both male and female)
PP date: The beginning of 2010 thru the beginning of 2012.
CT.gov date: October 2008 thru June 2010.
This trial had two variables: single injections vs. repeat injections; and epidermal + dermal cells vs. dermal cells. It injected cells the day after they were harvested from culture.
Although it is hard to determine how these variables contribute to the aggregated data on the powerpoint, overall this trial had about a 50% response rate.
Second Phase 2 Test
CA-2062 Ji Gami DO (enrollment 21, both male and female)
PP date: unknown
CT.gov date: June 2009 thru September 2010.
This trial tested only Dermal cells, similar to the old Intercytex method.
Interestingly, this trial peaked at a 65% response rate, which perhaps signifies that Dermal cells alone are more potent than the Epidermal + Dermal cells used in the first trial. This is difficult to determine, however, because the first trial tested two variables (including strictly Dermal cells) and we can't be certain which independent variables led to higher/lower response rates.
Third Phase 2 Test
CA-2013 Ji Gami (enrollment 33, both male and female)
PP date: unkown
CT.gov date: January 2009 thru August 2010
This trial was very similar to the first trial but did not include injections of Ji Gami DO (purely Dermal cells) and it re-injected the cells on the day the cells harvested from culture, not the day after they were harvested. This appears to have improved the potency of the cells, because efficacy maxed out at 70%.Comment
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The (potentially) good news:
All of these tests apparently fall into the first arm of Ji Gami tests listed on the PowerPoint, so Ji Gami C, Ji Gami N, Ji Gami NDO, and Ji Gami CN all have the ability to improve on the results.
The later trials have VASTLY increased their sample sizes as well. Enrollments have gone from 20s to 40s to 100 in Ji Gami CN. Maybe this indicates confidence?
The (potentially) bad news:
The differences between each one of the portfolio products isn't that much different. Some they use two cells, others just one cell. Some they wait a day, others they don't. It's basically one technology with different best practices. Therefore results might not be able to improve THAT much from the initial phases.
Other variables currently being tested include:
Whether or not plucking hairs from the excised scalp will improve the potency of the cells in culture.Comment
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Joker, the time and attention that you have taken is very much appreciated. Thank you so much. It is all so very interesting to read.
I feel very positive about ARI ..the concept is amazing to begin with.Comment
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Joker, you're amazing brother! That's one hell of investigative research put together. Thanks for sharing.
Btw guys, do you know how large was the treatment areas? (crown, temples, vertex, or all of the above?)
I've read some comments by some guy that claims he was part of the 2010 trials , he goes by the name "Bald Half-truth" and he reckons the treatment was only on a small part of his crown. It thickened up a little bit, but it mostly halted his hairloss!Comment
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