OC000459? (Yes that's its name)

[neversaynever]

It's a bold and, to be honest, completely unjustified statement, nobody can honestly say they are 99% sure... but there is definitely a theoretical basis for believing that it could work extremely well, if baldness really is caused by unbalanced PGs.

An 'analog' in pharmacology is a molecule has the same effect as another molecule - usually meaning, a synthetic drug that has the same effect as a natural protein/enzyme/whatever. In this case meaning a drug that binds to the same receptors in the hair follicle as PGE2 does. PGE2 is one of the 'good' prostaglandins.

So you want a PGE2 analog and a PGD2 inhibitor. And the other PGs are in there too somewhere...

Im not so knowledge. Upto a few months ago I thought PGs was a type of tea.

Im very curious about histogen and prostaglandins. Does HSC involve prostaglandins? Theyre getting good growth rates, surely that means they are restoring the balance in good and bad PG's?

[2020]

Are there any obtainable compounds that act as PGE2? I'd love to see 2020 go through with it.

yes, and they're very expensive. People on HLH are trying to form a group buy so they can obtain it cheaper.

[2020]

Im very curious about histogen and prostaglandins. Does HSC involve prostaglandins? Theyre getting good growth rates, surely that means they are restoring the balance in good and bad PG's?

that's a million dollar question

if your hair(or lack of it) is just a product of the ratio of certain good and bad prostaglandins, then in order to grow hair there must be something that changes that "ratio" in a hair positive way....

I hope HSC does truly change PG ratio otherwise I can't see how it would work besides just forcing your hair into anagen phase which would only last once but for at least a couple years...

[NeedHairASAP]

yes, and they're very expensive. People on HLH are trying to form a group buy so they can obtain it cheaper.

why doesn't somebody just start a company instead of some amateur group buy... it would work out the same and probably be easier to finance.

[2020]

why doesn't somebody just start a company instead of some amateur group buy... it would work out the same and probably be easier to finance.

what are you talking about?

[NeedHairASAP]

what are you talking about?

I mean somebody start a ****ing company. Sell bonds or shares. Get a shitload of money. Buy a load of what you're talking about. Try it. If it works, then buy a shitload of the shit you're talking about and sell that shit for a shitload of money more than originally invested. TRX4/spectral f7 style.

[bananana]

well, if it DOESN'T work, you got yourself a shitload of shit that wont work and you've lost a shitload of money.

so, at least 5-10 people gotta try it first, see if it works and if it does somebody will open the company, don't worry.

[ppxrare]

When can we expect news on whether PGD2 inhibitors work or not, and if they do work how long do you guys think it will take for a product to be out there.

[NeedHairASAP]

Did this guy get the ocoooo459 yet or what?

[2020]

Did this guy get the ocoooo459 yet or what?

"I got a replay on Friday, They are now with the Latest synthesis step of OC000459. They told me its harder then expected to make it 99% pure.. So I hope everything goes well and that we have it within the next days/2 weeks.. "


all of this is happening on HLH:

http://www.hairlosshelp.com/forums/messageview.cfm?catid=7&threadid=99747&STARTPAGE=1&FTVAR_FORUMVIEWTMP=Linear

[Aston]

Just to stir the moldy pudding over here: http://www.ncbi.nlm.nih.gov/pubmed/11589743

(@Gutted: it seems the production of TNFa is typically increased during metabolic imbalances connected to certain dietary disorders and is a major inflammation kickstarter.)

[NeedHairASAP]

Just to stir the moldy pudding over here: http://www.ncbi.nlm.nih.gov/pubmed/11589743

(@Gutted: it seems the production of TNFa is typically increased during metabolic imbalances connected to certain dietary disorders and is a major inflammation kickstarter.)

whats your point?


diet can kick start inflammation in the scalp?

[Aston]

There are known and proven associations, but it's still nebulous. I have started a thread about one possible theory days ago.

[Kirby_]

When can we expect news on whether PGD2 inhibitors work or not, and if they do work how long do you guys think it will take for a product to be out there.

Well, for it to work, I imagine that the first-wave of users would need 3 to 6 months to judge the effects, preferably 6. Hypothetically.

[2020]

Just to stir the moldy pudding over here: http://www.ncbi.nlm.nih.gov/pubmed/11589743

(@Gutted: it seems the production of TNFa is typically increased during metabolic imbalances connected to certain dietary disorders and is a major inflammation kickstarter.)

come on dude.... those people on IH take everything to the extreme too and NO ONE has regrew any hair. When can we put this "MPB due to lifestyle" theory to rest???

I personally know people who are pretty much on life support due to the number of drugs they're taking and yet they have a full head of hair. Explain that