OC000459? (Yes that's its name)

[youngsufferer]

I can't stress this enough, if this doesn't work we are all ****ED.

[re22]

Why? This isn't the only thing going on.

[Kirby_]

maybe we won't have to.... maybe inhibiting PGD2 ONLY will give us desirable results.
Minox increases PGE2 somewhat so there's that.

I also hope that PGD2-inhibitors alone will be good enough, if only for the sake of everyday convenience! I'm sure that enough forum-goers will be using individual or combo treatments for us to get a decent general idea if the latter gets significantly better results.

well he was the one who discovered this PGD2 thing so it's totally fair to claim a patent on it

Fair enough, just wish he'd get a move on in terms of implementing the newfound knowledge for the benefit of the balding public...

[gutted]

a combination approach would be required for this though, i think a good antibacterial agent is also neccasary to stop the cause of the upregulation, or it'll be a tug of war scenario.

also a good vehicle to get the agent into the dermal papilla.

[Gjm127]

Question: If the OC000459 pill was taken orally through the clinical trials for that allergy treatment... Why didn't anyone see their hair grow back (to some extent) ?

[2020]

a combination approach would be required for this though, i think a good antibacterial agent is also neccasary to stop the cause of the upregulation, or it'll be a tug of war scenario.

also a good vehicle to get the agent into the dermal papilla.

you have no idea what you're talking about... just go back to IH forums

[2020]

Question: If the OC000459 pill was taken orally through the clinical trials for that allergy treatment... Why didn't anyone see their hair grow back (to some extent) ?

because the trial lasted only 2 months or so

[gutted]

you have no idea what you're talking about... just go back to IH forums

are you having a laugh? at best this would provide results on par with minoxidil, minoxidil has been claimed to be workking via the prostglandins mechanism for years in some people, yet this is not enough to stop someone from going bald. i wonder why!

your best bet if you want to maintain your hair is get on a androgen recepter blocker, before its too late.

this is all experimental and there is no garantee that this will be working.

[2020]

are you having a laugh? at best this would provide results on par with minoxidil, minoxidil has been claimed to be workking via the prostglandins mechanism for years in some people, yet this is not enough to stop someone from going bald. i wonder why!

your best bet if you want to maintain your hair is get on a androgen recepter blocker, before its too late.

this is all experimental and there is no garantee that this will be working.

first of all, minoxidil is not that effective at raising PGE2 levels. A direct PGE2 would be a much better solution.

second: the reason why minoxidil doesn't work that well is because it doesn't take care of the main problem which is excessive PGD2 which is very good at inhibiting hair growth

[Davey Jones]

are you having a laugh? at best this would provide results on par with minoxidil, minoxidil has been claimed to be workking via the prostglandins mechanism for years in some people, yet this is not enough to stop someone from going bald. i wonder why!

your best bet if you want to maintain your hair is get on a androgen recepter blocker, before its too late.

this is all experimental and there is no garantee that this will be working.

Minox only increases PGE2. And I'm not even sure how much. Supposedly, the larger effect (the inhibition of hair growth, rather than the promotion of it) is due to PGD2. Minox doesn't nothing to inhibit conversion of compounds into PGD2 or block PGD2 from binding with its receptor site. OC000459 blocks PGD2's receptor site.

Though I do think your question about what the vehicle would be is interesting. I'm wondering the same thing, myself. Do you guys have an idea for that yet, 2020, or is there a reason that that's a stupid question?

[gutted]

http://divineskin.com/uk/spectralDNC-L/BJD150MinoxidilMech.PDF

[gutted]

Minox only increases PGE2. And I'm not even sure how much. Supposedly, the larger effect (the inhibition of hair growth, rather than the promotion of it) is due to PGD2. Minox doesn't nothing to inhibit conversion of compounds into PGD2 or block PGD2 from binding with its receptor site. OC000459 blocks PGD2's receptor site.

Though I do think your question about what the vehicle would be is interesting. I'm wondering the same thing, myself. Do you guys have an idea for that yet, 2020, or is there a reason that that's a stupid question?

the vehicle is key, if thats not right, this will be a failiure.

[gutted]

first of all, minoxidil is not that effective at raising PGE2 levels. A direct PGE2 would be a much better solution.

second: the reason why minoxidil doesn't work that well is because it doesn't take care of the main problem which is excessive PGD2 which is very good at inhibiting hair growth

you need to look at the bigger picture, theres a reason why dr cots has been holding onto the patent since 2008...

your going to block pgd2 on one hand and then increase dht on the other....i dont see it working...it'll probably provide results the same as minox and baldness will advance sureley but slowly.

lets hope im wrong though!

[neversaynever]

I also hope that PGD2-inhibitors alone will be good enough, if only for the sake of everyday convenience! I'm sure that enough forum-goers will be using individual or combo treatments for us to get a decent general idea if the latter gets significantly better results.


Fair enough, just wish he'd get a move on in terms of implementing the newfound knowledge for the benefit of the balding public...

I dont get it. He has the knowledge, and the patent, so why no word on solutions? Hes passing the buck to other companies. I can only think because if a big pharma find an amazing treatment, theyll have to pay him royalties. Ive seen a video of him saying that there are a number of companies already testing pgd2 blockers (not for hair loss). This implies that he has no desire to provide the 'solution'.

Maybe he knows its not the silver bullet? Or maybe he knows it will be big and he will rake in millions in royalties?

Also, does anyone know the relationshp of pge2 and pgd2? Does pgd2 directly decrease the amount of pge2 in balding areas? If the pge2 levels are lower, regardless of pgd2 levels, then a pgd2 blocker is not enough really.

What about allergens treatment? Does dr cots mention pgf2a levels in balding areas?

[2020]

you need to look at the bigger picture, theres a reason why dr cots has been holding onto the patent since 2008...

and what would be the reason? Maybe his company - follica is working on some PGD2 stuff you never know

your going to block pgd2 on one hand and then increase dht on the other....i dont see it working...it'll probably provide results the same as minox and baldness will advance sureley but slowly.

why would I increase DHT?