CB-03-01 - new antiandrogenic

[hellouser]

Maintain and thicken existing hair like Fin/RU. CB-03-01 binds to androgen receptors( like RU58841 ) so androgens can't bind and do any damage. It won't regrow any hair on a slick bald area.

many vellus hairs could and should turn terminal. from cosmo's presentations, hair became about 50% thicker, with 40% more hair count. both of these factors should make a world of a difference in terms of overall density.

[goldbondmafia]

Maintain and thicken existing hair like Fin/RU. CB-03-01 binds to androgen receptors( like RU58841 ) so androgens can't bind and do any damage. It won't regrow any hair on a slick bald area.

oh for sure, I don't expect anything to regrow hair on a slick bald area, just looking for something that may regrow thinning hair for my hairline personally. Don't know if I should try minoxidil or wait for CB...

Too early to tell. We'll know in the coming months with Kane's CB.

Is Kane's supposed to be legit compared to other sources for getting CB? Good to hear they are on it though

[BudskiiHD]

many vellus hairs could and should turn terminal. from cosmo's presentations, hair became about 50% thicker, with 40% more hair count. both of these factors should make a world of a difference in terms of overall density.

Hmm, but the results that are possible with cb-03-01 should also be achievable with RU58841 since they are both doing the same thing. Maybe CB-03-01 has higher binding affinity when compared to RU58841, or maybe cb-03-01 reaches the target better when compared RU58841. But, note in the CB-03-01 POC study they did use Iontophoresis which certainly improved the results. So yeh, I guess we will have to wait and see. But honestly, I don't think think it's anything to be really hyped about, but it is something I guess. Since once FDA approved it will be cheaper and no "bad batches" as with RU. I'd rather just call it the "convenient RU58841".

[StayThick]

Iron dragon updated their website, said its cb is now available in 1 week instead of 5. Plus they wrote this.

http://www.iron-dragon.com/product_info.php?products_id=238&osCsid=45ba21cb835e928582ad1606e7320d7b

CB is in clinical trials for acne, what vehicle are they using for that? Im guessing itll be the same as it needs to penetrate the skin for it to work against acne.

I'll jump on this if its premixed. Anybody know if Iron Dragon will be offering this in a premixed version?

I hope it doesn't ruin my eyes like RU did...fingers crossed

[mari0s]

many vellus hairs could and should turn terminal. from cosmo's presentations, hair became about 50% thicker, with 40% more hair count. both of these factors should make a world of a difference in terms of overall density.

these results were archived by using iontophoresis, don't forget. The best thing should be buying the machine and make a try but you must be know how to use it

[mari0s]

Ok i know is an 3 yrs old proof of concept but i was look at it and something occurred to my mind.



Forget about cb-03-01 for a moment and look the results of cyproterone acetato and 17a-estradiol. They seems pretty amazing, i would be more than happy if the cyproterone that i use in my lotion + minox would have given that result.

Plus the effect seems to continues even after 4 weeks the treatments is done (which is not occur with a topical lotion that you have to use every day)

So maybe (maybe) our approach is quite wrong, it's more HOW to apply rather than What apply.

On a old thread on another site a user has writed this:
"The follicle actually lies fairly deep under the skin. Iontophoresis is interesting because research suggests that it largely aids transdermal absorption by sending the active ingredient down the hair shaft.

The ideal scenario would be finding someone who can create cationic liposomes to encapsulate active ingredients. Then you could use a (fairly inexpensive) iontophoresis device to deliver it."

I dont have the knowledge to try, maybe someone has

[yan]

Not specifically related to CB 03 01:

Lainate, Italy – 31 July 2013
Cosmo reports excellent first half; new product sales exceed expectations and important progress is attained in products in development strong increase in profits

http://www.cosmopharmaceuticals.com/news/press/pr2013/2013-07-31.aspx

Some other info from the half-year report:

"Work on attaining the proof of concept in CB-03-01 for Alopecia continues making progress."

"Valeant, who acquired our licensee Medicis late last year, has reiterated its high strategic interest in this product."

"The development of CB-03-01 continues as planned. The phase II for acne calls for 4 cohorts of 90 patients each to be treated with ascending doses. Currently patients for the third cohort are being recruited. To date there have been no major adverse events."

"For CB-03-01 the Company believes it has an optimal solution in being assisted in the management of the phase II trials by the experience professionals of Intrepid Therapeutics Inc. and an optimal long term licensing partnership with Valeant who is the leader in skin diseases in the US."

"CB-03-01 is applied topically. It penetrates the skin well and acts by displacing the androgen from the sebaceous gland or hair follicle."

Half-year report:

http://www.cosmopharma.com/~/media/Files/C/Cosmo-Pharmaceuticals/half-year%20report-31-7-13.pdf

[TravisB]

Not specifically related to CB 03 01:

Lainate, Italy – 31 July 2013
Cosmo reports excellent first half; new product sales exceed expectations and important progress is attained in products in development strong increase in profits

http://www.cosmopharmaceuticals.com/news/press/pr2013/2013-07-31.aspx

Some other info from the half-year report:

"Work on attaining the proof of concept in CB-03-01 for Alopecia continues making progress."

"Valeant, who acquired our licensee Medicis late last year, has reiterated its high strategic interest in this product."

"The development of CB-03-01 continues as planned. The phase II for acne calls for 4 cohorts of 90 patients each to be treated with ascending doses. Currently patients for the third cohort are being recruited. To date there have been no major adverse events."

"For CB-03-01 the Company believes it has an optimal solution in being assisted in the management of the phase II trials by the experience professionals of Intrepid Therapeutics Inc. and an optimal long term licensing partnership with Valeant who is the leader in skin diseases in the US."

"CB-03-01 is applied topically. It penetrates the skin well and acts by displacing the androgen from the sebaceous gland or hair follicle."

Half-year report:
http://www.cosmopharma.com/~/media/F...rt-31-7-13.pdf

Hmm, I wonder how will they deal with potentiall skin atrophy side effect, since CB-03-01 is a steroid. If we were to apply it to our scalps for the rest of our lives, it better NOT cause such serious side effect as skin atrophy.

[mari0s]

"CB-03-01 is applied topically. It penetrates the skin well and acts by displacing the androgen from the sebaceous gland or hair follicle."

Half-year report:
http://www.cosmopharma.com/~/media/F...rt-31-7-13.pdf

Off course their final product must be a topical but given the great results they have archived even with the 17a-estradiol make me think that this way will be less effective than ionophoresis, in their R&D day of january they don't speak about the results they had with their new vehicle only about skin permeation test.

[Hairismylife]

Apply CB right after derma rolling could help

[yan]

Hmm, I wonder how will they deal with potentiall skin atrophy side effect, since CB-03-01 is a steroid. If we were to apply it to our scalps for the rest of our lives, it better NOT cause such serious side effect as skin atrophy.

Is there even a minimum chance that it doesn`t cause this side effect?

Because as far as I know, every topical steroid can cause this side effect...

If steroid atrophy is a side effect of CB, then its useless and not worth the risk. I would rather take a mini dose fin for the rest of my life than risk steroid atrophy on my head.

[KeepHoping]

Do you guys think it will have to be delivered through a specific vehicle to actually work? Will this IronDragon site sell the right formulation and is it legal for them to sell it? I need some insight from you guys because I'm sure you all know more than I do about the legal process of patented drugs and delivery mechanisms and whatnot. Thank you in advance.

[hellouser]

Do you guys think it will have to be delivered through a specific vehicle to actually work? Will this IronDragon site sell the right formulation and is it legal for them to sell it? I need some insight from you guys because I'm sure you all know more than I do about the legal process of patented drugs and delivery mechanisms and whatnot. Thank you in advance.

If they sell you legitimate CB, YOU have nothing to worry about other than the potential side effects (skin atrophy, although at 10mg dosage spread out across a large area of scalp is probably too little to make a difference).

[TravisB]

Is there even a minimum chance that it doesn`t cause this side effect?

Because as far as I know, every topical steroid can cause this side effect...

If steroid atrophy is a side effect of CB, then its useless and not worth the risk. I would rather take a mini dose fin for the rest of my life than risk steroid atrophy on my head.

If the steroid is relatively weak, and isn't applied every day (CB is meant to be applied once a week), then maybe that side effect can be avoided, but I'm not an expert. However I'm not sure what would happen after very prolonged use even with once a week application.

Note that CB-03-01 is now into Phase II for acne and they report no serious side effects, and it's also applied to the skin (however I don't know how often), so maybe they avoided skin atrophy side effect somehow.

[hellouser]

Wikipedia article on steroid skin atrophy

http://en.wikipedia.org/wiki/Steroid_atrophy