CB-03-01 - new antiandrogenic

[FearTheLoss]

CB is most similar to RU, but with fewer sides.


In theory. Unless you're sensitive to cortisol.

CB also has anti-inflammatory properties...in theory it should be better than anything on the market because it works multiple angles.

[KO1]

^Ah...high levels of cortisol cause: http://en.wikipedia.org/wiki/Cushing%27s_syndrome

If you're sensitive to cortisol, well then...

[clandestine]

Any way to know or test if someone is sensitive to cortisol /corticosteroids?

KO;

[KO1]

No idea, sorry.

[Desmond84]

Any way to know or test if someone is sensitive to cortisol /corticosteroids?

Hey Clan

Ppl are generally not sensitive to steroids as it is used for skin sensitivity! However, prolonged use on a daily basis may cause skin atrophy (thinning of the epidermal layer) meaning your skin may break very easily when scratching etc.

CB-03-01 is a ONCE WEEKLY formulation, which may not have such detrimental effects on the skin but then again we don't know! For those lucky ones that tolerate Finasteride, they may be able to switch between fin & CB on a monthly basis to allow the epidermal layer to return to its original density. If you don't tolerate fin (and I know you don't brother) an option would be to apply it ONCE WEEKLY for 3 weeks then allow a ONE WEEK CB-free period before starting this routine again!

That's how we treat kids with severe eczema! 7-10 day drug holiday generally allows their skin to go back to normal.

[Hairismylife]

Hey Clan

Ppl are generally not sensitive to steroids as it is used for skin sensitivity! However, prolonged use on a daily basis may cause skin atrophy (thinning of the epidermal layer) meaning your skin may break very easily when scratching etc.

CB-03-01 is a ONCE WEEKLY formulation, which may not have such detrimental effects on the skin but then again we don't know! For those lucky ones that tolerate Finasteride, they may be able to switch between fin & CB on a monthly basis to allow the epidermal layer to return to its original density. If you don't tolerate fin (and I know you don't brother) an option would be to apply it ONCE WEEKLY for 3 weeks then allow a ONE WEEK CB-free period before starting this routine again!

That's how we treat kids with severe eczema! 7-10 day drug holiday generally allows their skin to go back to normal.

Thanks Desmond!

Once a week, should in what amount?

[Dan26]

Hey Clan

Ppl are generally not sensitive to steroids as it is used for skin sensitivity! However, prolonged use on a daily basis may cause skin atrophy (thinning of the epidermal layer) meaning your skin may break very easily when scratching etc.

CB-03-01 is a ONCE WEEKLY formulation, which may not have such detrimental effects on the skin but then again we don't know! For those lucky ones that tolerate Finasteride, they may be able to switch between fin & CB on a monthly basis to allow the epidermal layer to return to its original density. If you don't tolerate fin (and I know you don't brother) an option would be to apply it ONCE WEEKLY for 3 weeks then allow a ONE WEEK CB-free period before starting this routine again!

That's how we treat kids with severe eczema! 7-10 day drug holiday generally allows their skin to go back to normal.

Hey Desmond, do you know what class steroid CB would be considered comparable too? Potent like beta or clobeatsol? More potent?

[clandestine]

Thanks so much for the reply Des, the clarification is much appreciated!

[Desmond84]

Hey Desmond, do you know what class steroid CB would be considered comparable too? Potent like beta or clobeatsol? More potent?

CB's a very unique steroid as it has anti-androgenic properties! No other corticosteroid has such properties, which could mean two things: either it's anti-androgenic properties has made its steroidal activity minimal at best or it has steroidal properties just like any other topical steroids out there!

The only way to answer your question Dan is to conduct a Phase 2 trial, which is happening as we speak! The results should be released by January 2014. We just have to hang tight The answers are coming

[Desmond84]

Thanks so much for the reply Des, the clarification is much appreciated!

No worries Clan

Thanks Desmond!

Once a week, should in what amount?

I don't remember exactly but I'm pretty sure Cosmo Pharmaceuticals tried the 5% formula with outrageous results!

[Hairismylife]

No worries Clan



I don't remember exactly but I'm pretty sure Cosmo Pharmaceuticals tried the 5% formula with outrageous results!

But, once a week, means 6 CB-free weekday, can't imagine it can help hairloss, as you know minoxidil is to be applied daily to work.

Btw, what vehicle should I use for CB? And 5% means how much CB in how much vehicle, sorry I'm a chemistry idiot

[Desmond84]

But, once a week, means 6 CB-free weekday, can't imagine it can help hairloss, as you know minoxidil is to be applied daily to work.

Btw, what vehicle should I use for CB? And 5% means how much CB in how much vehicle, sorry I'm a chemistry idiot

It blocks the androgen receptors for about a week before being washed away, hence once weekly dosing

With regards to vehicle and strength...it is going to be very difficult to find the right one ATM...so far we know that only ionopheresis can provide adequate topical absorption to halt hairloss. There is no data on other vehicles which makes in-house manufacturing quite difficult!

Ionopheresis is a device that costs $200-$300 and tbh I'm not quite sure how to use it! Has anyone actually tried the ionopheresis method btw?

P.S. No question is stupid to ask? That's why we're here brother

[Hairismylife]

It blocks the androgen receptors for about a week before being washed away, hence once weekly dosing

With regards to vehicle and strength...it is going to be very difficult to find the right one ATM...so far we know that only ionopheresis can provide adequate topical absorption to halt hairloss. There is no data on other vehicles which makes in-house manufacturing quite difficult!

Ionopheresis is a device that costs $200-$300 and tbh I'm not quite sure how to use it! Has anyone actually tried the ionopheresis method btw?

P.S. No question is stupid to ask? That's why we're here brother

Hellouser is using CB but I dunno what vehicle he use, i'm waiting his response

Actually I'm using Mpbt premixed RU but i'm worry about any possible side effect,
is RU such a risky thing that you dont suggest using?

I remember RU has ever passed Phase 1 testing this means that it's safe?

[KO1]

The key is that androgen receptors take some time to regenerate, but I don't know if that is days or hours. Anyone know?

With regards to vehicle and strength...it is going to be very difficult to find the right one ATM...so far we know that only ionopheresis can provide adequate topical absorption to halt hairloss.

They're using an anhydrous vehicle, so strong chance it could be E/PG. The cream is for acne, but we may not need it.

CB's a very unique steroid as it has anti-androgenic properties! No other corticosteroid has such properties, which could mean two things: either it's anti-androgenic properties has made its steroidal activity minimal at best or it has steroidal properties just like any other topical steroids out there!

It should be milder than other corticosteroids as it becomes converted to cortodoxone which is less potent than cortisol which is far less potent than clobetasol. Just my guess.

I don't remember exactly but I'm pretty sure Cosmo Pharmaceuticals tried the 5% formula with outrageous results!

They have said the 5% formula is for AGA, but where did u see their results out of curiosity?

[Hairismylife]

The key is that androgen receptors take some time to regenerate, but I don't know if that is days or hours. Anyone know?



They're using an anhydrous vehicle, so strong chance it could be E/PG. The cream is for acne, but we may not need it.



It should be milder than other corticosteroids as it becomes converted to cortodoxone which is less potent than cortisol which is far less potent than clobetasol. Just my guess.



They have said the 5% formula is for AGA, but where did u see their results out of curiosity?

Can use KB solution instead?