CB-03-01 - new antiandrogenic

[Mike K]

H2 or 2H means second half of 2014. IND is Investigational New Drug which is what they need to get approved by the FDA before they can conduct clinical trials in the US.

Thank you. Anyone have any vehicle info?

[Pate]

What does H2 and IND mean? Also isn't the problem with this stuff that there isn't a good vehicle for it? Does anyone know what vehicle they are planning to use in the trials?

H2 or 2H means second half of 2014. IND is Investigational New Drug which is what they need to get approved by the FDA before they can conduct clinical trials in the US.

They have been doing a lot of work on the vehicle. They have said what the vehicle is based on but I forget. Maybe someone else remembers.

[lilpauly]

I have full confidence in regards to CB and Cosmo being able to bring it to commercialization, unlike Histogen and those other start ups, Cosmo is a pharmaceutical company.

This is though, its essentially topical fin/dut without sides - if I wait before its released - even just the acne version so we can reverse engineer it I will probably be something like diffuse nw6 with recession to NW4 because I have aggressive MPB. I don't know what to bridge these 1-2 years with... RU? Dut made me piss like a mad man and infact Im still ****ed from it but its been only 3 days and Im getting better.

I have hopes in in bim as well!!!!

[LMS]

I have full confidence in regards to CB and Cosmo being able to bring it to commercialization, unlike Histogen and those other start ups, Cosmo is a pharmaceutical company.

This is though, its essentially topical fin/dut without sides - if I wait before its released - even just the acne version so we can reverse engineer it I will probably be something like diffuse nw6 with recession to NW4 because I have aggressive MPB. I don't know what to bridge these 1-2 years with... RU? Dut made me piss like a mad man and infact Im still ****ed from it but its been only 3 days and Im getting better.

[lilpauly]

What does H2 and IND mean? Also isn't the problem with this stuff that there isn't a good vehicle for it? Does anyone know what vehicle they are planning to use in the trials?

Hi they might give more info next month regarding the vehicle in quarterly update

[Mike K]

- 120 patient Phase II POC trial comparing CB, minox and placebo for alopecia due to start in H2 2014, with IND filing in April.

What does H2 and IND mean? Also isn't the problem with this stuff that there isn't a good vehicle for it? Does anyone know what vehicle they are planning to use in the trials?

[burtandernie]

I think CB with a decent long term study showing it stops MPB can sell plenty by saying it prevents MPB with no sexual sides, and actually has the evidence proving its true. If it can become over the counter eventually it could sell big time.
The sexual sides and other possible problems did not help propecia with its sales

[Sogeking]

Updates from Cosmo on CB just released today.

- Phase II for acne completed in February, top line results expected in April.
- FDA has waived the requirement for a systemic carcinogenicity trial, which must mean they are satisfied there is no systemic absorption!
- $20M payment due from Valeant for the completion of Phase II milestone
- 120 patient Phase II POC trial comparing CB, minox and placebo for alopecia due to start in H2 2014, with IND filing in April.

Finally looks like some action on this front. Unlike most of these deadbeat startups like Histogen and Replicel, Cosmo is actually very successful financially so funding shouldn't be an issue. If the drug works in this trial I think there is a good chance it might be developed for sale (officially, not Chinese!).

They say it is on track for acne but slightly behind schedule for alopecia. Typical...

Here's hoping mate. I am stoked for this. And I like the fact that Phase II for alopecia will compare it both to minox and placebo.
Go Cosmo...

[BDDFreak]

Excellent, unless I am mistaken CB-03-01 is just about the only thing on the horizon, without this it will be a huge wait too long for some of us.
It may not be the best thing to hit the market but it will be the only thing of substance.

I think bimatoprost is also on the horizon. With cb, bimatoprost and pilofocus which most likely will be in practice by 2015 then we can consider a lot of ppl essentially "cured" .

[Hair Bear]

Excellent, unless I am mistaken CB-03-01 is just about the only thing on the horizon, without this it will be a huge wait too long for some of us.
It may not be the best thing to hit the market but it will be the only thing of substance.

[simba]

Updates from Cosmo on CB just released today.

- Phase II for acne completed in February, top line results expected in April.
- FDA has waived the requirement for a systemic carcinogenicity trial, which must mean they are satisfied there is no systemic absorption!
- $20M payment due from Valeant for the completion of Phase II milestone
- 120 patient Phase II POC trial comparing CB, minox and placebo for alopecia due to start in H2 2014, with IND filing in April.

Finally looks like some action on this front. Unlike most of these deadbeat startups like Histogen and Replicel, Cosmo is actually very successful financially so funding shouldn't be an issue. If the drug works in this trial I think there is a good chance it might be developed for sale (officially, not Chinese!).

They say it is on track for acne but slightly behind schedule for alopecia. Typical...

Thats great news, do you have any idea how long the Phase II trial will last?

[Pate]

Updates from Cosmo on CB just released today.

- Phase II for acne completed in February, top line results expected in April.
- FDA has waived the requirement for a systemic carcinogenicity trial, which must mean they are satisfied there is no systemic absorption!
- $20M payment due from Valeant for the completion of Phase II milestone
- 120 patient Phase II POC trial comparing CB, minox and placebo for alopecia due to start in H2 2014, with IND filing in April.

Finally looks like some action on this front. Unlike most of these deadbeat startups like Histogen and Replicel, Cosmo is actually very successful financially so funding shouldn't be an issue. If the drug works in this trial I think there is a good chance it might be developed for sale (officially, not Chinese!).

They say it is on track for acne but slightly behind schedule for alopecia. Typical...

[hellouser]

Yeah I like how the community drops the most promising things and pursues the dumbest ones like laser helmets.

Dalek Helmets:




[/QUOTE]

[burtandernie]

Yeah I like how the community drops the most promising things and pursues the dumbest ones like laser helmets.

[HairBane]

Well whatever work gets done on it is going to be mostly educated guess work about how to reverse engineer this stuff. You're welcome to try buying the ingredients yourself and having a crack at it.

Just a thought, but when Cosmo eventually release the CB in acne cream form (maybe next year? they're starting phase 3 now I think), could we just switch out a few of the ingredients which are bad for hair, and up the percentage ourselves?