Will an official cure ever be found? Honestly

[mlamber5]

It is related to aging in the sense that it begins more or less at puberty. How it progresses is variable from person to person. But it is not a result of the universal, systemic decline that follows the age of 25 (for most people). If there is any correlation to age (I've never heard your 20%/20's, 30%/30's timeline before), it is only because the process is different from person to person, genetics depending; for some it progresses so rapidly that it is cosmetically noticeable by their 20's, for others by their 30's, etc.

I firmly believe that it is an autoimmune disorder, and that the JAK studies will bear fruit. That being said, there are several promising protocols in the pipeline, and if one of them hits, it will be in less than ten years, as all of them are in Phase I trials or later. If none of them work, then yes, the timeline gets significantly longer.

Pretty much my thoughts exactly. We've moved on from a DHT centered point of view. Got to have DHT to start it all off but castration wont reverse hair loss because the follicle is still suspended in the resting phase. There are those with the "bad" variant of the Androgen receptor gene that still do not bald, or do not bald prematurely. Plus androgen levels decline as we age and the rate of Androgenic Alopecia increases. It makes no sense if you are viewing this completely from an androgen induced point of view. JAK induced Stat 3 protein is responsive to the Androgen Receptor and I believe that interplay is what is causing the cascade of events leading to hair cycle deregulation (and thus miniaturization.) I also believe the JAK studies will prove to be the cure we are looking for, and perhaps sooner rather than later. You would take a cream of highly concentrated JAK inhibitor enough to kick start the growth cycle back, and then use as needed to maintain in the future. Angela Cristiano's paper on topical effects of jak-stat inhibition on the hair follicle was truly enormous and should have all very excited.

[Occulus]

Oh man. Its candy. Take it.

I just found out what the treatment for hipersexuality in old men is.
Finasteride.
http://www.alzheimersanddementia.com...554-5/fulltext

Good find! "This study demonstrates that finasteride as an anti-androgenic effect decreased libido and hypersexual behavior without serious side effects in patients with vascular dementia and underlying BPH. Further studies that obviously define the response and long-term side effects of finasteride are needed to confirm our observations." Yikes...

[dutchguyhanging]

Tons of men that go bald have gone on to be centenarians. I don't agree that hair loss has anything to do with aging especially since I was a NW6 by 25

i think ur question has been answered above.. but i will respond u again.. yes it is related to aging. for some people it is early 20s for some its early 70s... it depends on people but there is positive correlation with aging process. not everyone dies at the same age right? apply the same logic

[boldat25]

ok guys one thing i need to make clearer for everyone here since i am working in one of the big pharma.. a lot money goes into R&D thats true. but there used to be more freedom on how researcher spent their money.. not anymore.. we are all focusing on treatments which could be viable within 2-3years timeframe....

i would all like to remind yo all how stemcell research market has been collapsed during last decade and there was literally no investment at that time. and now it is coming back again.. if investors dont see payoff it will collapse again..

u remember when we did dolly- it was 96... 20 years ago.. they cloned a ship 20years ago and we can not clone one single hair? yes thats sad but true..

in short never ever ever ever give timeline.. it could be tomorrow it could be 50years from now... hairloss is also related with ageing process so not easy equation to solve...

Tons of men that go bald have gone on to be centenarians. I don't agree that hair loss has anything to do with aging especially since I was a NW6 by 25

[Trouse5858]

Maybe there will be a treatment in our lifetime.. but not in our youth
Maybe itll be in our 40s or 50s, but honestly i would prefer to spend money on my kids rather on my stupid hair
Im 25 years old.. the next treatment as usual is 5 years away.. i prefer to live my life till 30 rather than pray for a stupid treatment
Research take lots and lots of years..

The next treatment isn't five years away though if you've been keeping up with a few of these companies. When the first treatment comes out and the vast majority of guys <Norwood 4 are ditching fin, minox and the experimental stuff, investors and other companies will see how insanely profitable this market is.

[Trouse5858]

Maybe there will be a treatment in our lifetime.. but not in our youth
Maybe itll be in our 40s or 50s, but honestly i would prefer to spend money on my kids rather on my stupid hair
Im 25 years old.. the next treatment as usual is 5 years away.. i prefer to live my life till 30 rather than pray for a stupid treatment
Research take lots and lots of years..

The next treatment isn't five years away though if you've been keeping up with a few of these companies. When the first treatment comes out and the vast majority of guys <Norwood 4 are ditching fin, minox and the experimental stuff, investors and other companies will see how insanely profitable this market is.

[Scientalk56]

Maybe

Maybe there will be a treatment in our lifetime.. but not in our youth
Maybe itll be in our 40s or 50s, but honestly i would prefer to spend money on my kids rather on my stupid hair
Im 25 years old.. the next treatment as usual is 5 years away.. i prefer to live my life till 30 rather than pray for a stupid treatment
Research take lots and lots of years..

[bboy5]

I think it's strange that it's become a kind of dogma that when finasteride works as it's "supposed" to it stops hair loss. It doesn't. The main FDA study merk produced shows finasteride increases hair count for 1 year after which you begin losing hair at the same rate, giving you an effective 5 year offset before you're back to square 1.

And it's common knowledge that drug companies are allowed to cherry pick their "best" studies to submit to the FDA (check out Ben Goldacre on this), meaning that in all likelihood it won't even work this well.

[topt]

Uh because I've been on for 3 years with no sides and I'd have lost most of it by now as a diffuser? It works.

Only people who spread the fact it's going to make you impotent are the old bald men who regurgitate false information bitterly because they were too scared leading to this loop you see?

Take it.

Oh man. Its candy. Take it.

I just found out what the treatment for hipersexuality in old men is.
Finasteride.

http://www.alzheimersanddementia.com/article/S1552-5260(08)02554-5/fulltext

[Hemo]

Don't you think if anyone had a definitive answer, there would already be a cure? My gut tells me yes - medical research/knowledge is sort of like Mohr's Law in that discoveries and technology accelerate our understanding and in turn treatments for other disorders. The problem in my opinion is whether or not pharma wants to invest in future treatments if the process continues to be prohibitively expensive.

[dutchguyhanging]

Look at the advances and explosion currently taking place in regenerative medicine and technology as a whole. Remember technology growth is exponential - not linear. It is absolute lunacy to believe there WON'T be something close to resembling "a cure" in the next 10 years.

yes and no.. I said it many times and gonna say it again.. probably u didnt hear it.. it is all about money.. people are not investing something which will happen in 10-15 years.. they will put their money on treatments close to 2-3 years timeline... market is fierce and competitive.. not one thinks or invest that much long term..

yes they are investing it but let me tell you this so u will understand hopefully. if GSK has 10x money and he has 2 projects 1-will happen in 2-3 years 2- MPB in 10 years.. they will invest 9x on 1 and 1x on MPB... they want to see ROI asap.. thats why companies can survive... there is literally no other way

[Trouse5858]

Technology advances exponentially yes, but I'm not sure this extends to bio-tech. There are a lot more nooks and crannies that need to be checked and unfortunately, it's far more complicated than say increasing computing capabilities. A huge part of it is also financially motivated. If there were an endless supply of funding for R&D we would probably have cured several major diseases by now and be conducting manned space explorations well outside our solar system. Sad but true

[Occulus]

Look at the advances and explosion currently taking place in regenerative medicine and technology as a whole. Remember technology growth is exponential - not linear. It is absolute lunacy to believe there WON'T be something close to resembling "a cure" in the next 10 years.

Biotech is not like IT tech - there is no "work-around" for trials. If a new piece of software doesn't work, take it offline and fix it. If a new piece of biotech doesn't work, people can suffer or even die. That's why growth in biotech is not "exponential" - you will always have to trial a new protocol, and that takes - at a minimum - 12 years. Even if you develop something in a country with fewer regulations, it's still going to take years and years to bring a new therapy to market. And unlike tech, you don't really "build on failures" like you do in IT - there are often few lessons to learn from a failed study other than the original hypothesis was wrong.

Will the time to market ever get compressed? Sure, when new approaches to testing are developed (for example, chips that can simulate biology, or even digital biological simulations), but those are not going to happen in the near term. For those of us alive right now, biotech development will always be a long, expensive, and laborious process.

[Ktownmatti]

10 years from now you will probably be able to get an entire body transplant FFS.

[Ktownmatti]

Look at the advances and explosion currently taking place in regenerative medicine and technology as a whole. Remember technology growth is exponential - not linear. It is absolute lunacy to believe there WON'T be something close to resembling "a cure" in the next 10 years.