Will an official cure ever be found? Honestly

[hairloss2thickhair]

One of the things hair needs is collagen. One form of collagen is called biosil that can be bought at the drug store. It has no side effects and it is working for me. I wasn't completely bald but my shiny scalp was showing through at my crown in a big way. My hair has stopped falling out and is now growing back. Has anyone else tried this?

[kuba197]

What about Follica? Any news?

[justbreezy]

I don't have any degree in any scientific matter, so, forgive me if it's a stupid question.. If you are able to modify the "genetic source" of a living creature, would it's body eventually adapt to that mutation? (Like, if you modify the DNA sequence related to it's height, would it, in time, grow bigger/ taller? ) Or only it's descendants would be able to benefit from such change?
From what I've seen from this technology, it seems they were able to alter the phenotype of a living mice, changing it's fur colour. I've readed somewhere else aswell that a team of scientists, using that technology, were able to "cure" two teenagers with a degenerative disease. Perhaps I'm overestimating CRISPR indeed, but.. Maybe if we were able to indentify the genes responsible for AGA and remove them, wouldn't our bodies adapt to that modification and resume our normal hair cycle / growth? I don't know, I think that, perhaps, I'm just emotionaly attached to that possibilty, sorry if I sounded a bit hostile with you implying otherwise, I just can't stand this disease anymore, and I'm also, like many young men here, desperate for a quick fix for this condition. The sooner, the better, cuz.. I won't be on my tweenties forever, and I fear that, even if the cure comes, It won't matter anymore once I've been stolen from my youth.

Well we know for a fact they're talking about human engineering from birth, this is great for the next generation if they decided that we can remove these defects such as an early onset of MPB. It can be used in drug development, research and perhaps entered into the human body as stem cells in a treament similar to replicel. Replenish your defected Dermal Papilla/Sheath cup cells with MPB disease free cells? Allowing you to grow healthy unminaturized follicles?

If i could go into my 40s with hair on my head then i would be happy. After that, i'd accept my age and let myself be bald.

In China it seems they're creating breeds of micro pigs for consumers to buy. Is it hard to conceive they could make a tweak to our DNA and reintroduce them as stem cells? Anyway, they're hoping to cure much more problematic and life threatening diseases, if they get round to it then i hope they can find a solution for MPB.

[Link Mahboi]

I definitely agree it is worth a shot, and I might be completely wrong. Hell, I haven't really studied molecular bio for 7 years...I am just falling short in understanding exactly how it would work that's probably because I know very little about follicle physiology. Would they isolate the DP cells, sequence the DNA, alter it and then clone them with altered DNA? As in a DP cell with no androgen receptors at all? I don't know.. don't know much about this.

I don't have any degree in any scientific matter, so, forgive me if it's a stupid question.. If you are able to modify the "genetic source" of a living creature, would it's body eventually adapt to that mutation? (Like, if you modify the DNA sequence related to it's height, would it, in time, grow bigger/ taller? ) Or only it's descendants would be able to benefit from such change?
From what I've seen from this technology, it seems they were able to alter the phenotype of a living mice, changing it's fur colour. I've readed somewhere else aswell that a team of scientists, using that technology, were able to "cure" two teenagers with a degenerative disease. Perhaps I'm overestimating CRISPR indeed, but.. Maybe if we were able to indentify the genes responsible for AGA and remove them, wouldn't our bodies adapt to that modification and resume our normal hair cycle / growth? I don't know, I think that, perhaps, I'm just emotionaly attached to that possibilty, sorry if I sounded a bit hostile with you implying otherwise, I just can't stand this disease anymore, and I'm also, like many young men here, desperate for a quick fix for this condition. The sooner, the better, cuz.. I won't be on my tweenties forever, and I fear that, even if the cure comes, It won't matter anymore once I've been stolen from my youth.

[paleocapa89]

Isn't ultimately this what FGF11 is trying in an other thread "I think I've hacked it"

He is trying to silence the androgen receptor by gene editing if I understood him correctly.

[justbreezy]

http://www.cnet.com/news/genetically-engineered-micropigs-to-be-sold-as-pets-yes-micropigs/

http://www.hairlosscure2020.com/brief-items-of-interest-january-2016/

Well according to various videos explaining, the CRISPR technology makes it more affordable and anybody with a particularly degree to manipulate and change the DNA. This is happening in the animal and plant world already, but the CRISPR technology should make this easier for anybody with a degree in biology to make these changes apparently. Could still need time to test, find the issues in the DNA sequences. I think they already found the defective chromosomes common in people with accelerated MPB? I'm just saying, maybe they can use this to even just bring a suitable topical treatment to the table quicker.

[BaldingEagle]

How about Replicel shows efficacy in vivo before we get all excited.

[jamesst11]

It is still worth a "shot", James.. You clearly underestimate the potential of this technology, and I'm talking about even bigger things than AGA.

I definitely agree it is worth a shot, and I might be completely wrong. Hell, I haven't really studied molecular bio for 7 years...I am just falling short in understanding exactly how it would work that's probably because I know very little about follicle physiology. Would they isolate the DP cells, sequence the DNA, alter it and then clone them with altered DNA? As in a DP cell with no androgen receptors at all? I don't know.. don't know much about this.

[BaldingEagle]

It is still worth a "shot", James.. You clearly underestimate the potential of this technology, and I'm talking about even bigger things than AGA.

James like myself has a masters in molecular biology. I think it's you who's overestimating this technology. Full genetic comprehension is decades away.

[Link Mahboi]

It is still worth a "shot", James.. You clearly underestimate the potential of this technology, and I'm talking about even bigger things than AGA.

[jamesst11]

I hope Replicell can do something, simply because they projected a 2018 release. I might last till then

However, i think there is a cure already. We just can't access it because of the issues around genenome editing. CRISPR CAS9 can eliminate MBP genes from future generations, it seems like you could essentially reverse gene damage too in current generations. I'm not an expert, but surely they can use this to reverse or even to discover more easily the causes behind MPB.

https://www.youtube.com/watch?v=TdBAHexVYzc

There are way too many genes involved in everything that is MPB to consider editing DNA sequences to cure it. I don't think this will ever be a possibility for AGA.

[justbreezy]

I hope Replicell can do something, simply because they projected a 2018 release. I might last till then

However, i think there is a cure already. We just can't access it because of the issues around genenome editing. CRISPR CAS9 can eliminate MBP genes from future generations, it seems like you could essentially reverse gene damage too in current generations. I'm not an expert, but surely they can use this to reverse or even to discover more easily the causes behind MPB.

https://www.youtube.com/watch?v=TdBAHexVYzc

[Swooping]

Is there any reason you think they are going to fail?

I would not have a sole reason for that.

But looking at their hypothesis;



Read what they say on the right. The consensus about the dermal papilla cells is that they are the master regulator of the hair follicle. The amount of dermal papilla cells is correlated with hair size. The dermal papilla cells exhibit androgen receptor expression. Androgens activate these receptors and that is basically how AGA starts.

Now in a healthy hair follicle cycle the dermal papilla niche moves in telogen and the DP niche loses some size apparently in this phase (a decrease of cells), however it's not much. When the hair cycle is going into an active growing phase again (anagen) the DP niche may recruit some cells from outside the niche.

This re-population might stem from dermal sheath cup cells but we don't know for sure really (first problem).

The second problem also is that these injections would probably need to catch the hair follicle cycle in such an exact manner when the recruitment is actively happening (early anagen). Replicel recently spoke about this too.

Another problem would be then even if you manage to succeed in that, you have probably only replaced a few DP cells and the hair is going into a anagen cycle of 2+ years again. Leaving you with no opportunity to replace these other DP cells.

In a miniaturized unhealthy hair follicle, recruitment isn't even happening and there is a plethora of other problems.

Everything has to be on point for them to succeed.

MPB destroys companies almost as well as it destroys hairlines.

True story lol.

[potato1987]

Red Korean seaweed has stopped my hair falling. I use the Purador hair loss therapy shampoo. Oil your hair and massage scalp nightly with coconut oil. Wash in the morning. Watch hair grow

Where did you find this red korean seaweed?

[rlbrown68]

More like 20 years we've been teased with "breakthroughs".

Anyone with a brain that wants hair is on Fin, everyone else is going to end up bald and disappointed.

I'm not a fan of playing with my hormones but I'd rather suffer mild sides than be "the bald guy".

I also agree with Notgivingup, it will likely be found accidentally during research or medicines treating conditions society actually cares about.

Red Korean seaweed has stopped my hair falling. I use the Purador hair loss therapy shampoo. Oil your hair and massage scalp nightly with coconut oil. Wash in the morning. Watch hair grow