US government owned patent on hair follicle neogensis

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  • lacazette
    replied
    Thank you Renee, really interesting !!

    It tells they found the methods to make functional hair follicle!

    " a need exists for methods and compositions capable of generating morphologically-correct, fully-developed, non-immunogenic human hair follicles. Such methods and compositions would be useful for treating conditions such as full- or partial-thickness skin loss, wounds, burns, scars, and hair loss. The present invention fills these needs by providing cellular compositions capable of hair growth, neogenesis, and regeneration"

    "The present invention provides compositions in the form of skin substitutes and microspheres comprising neural crest-derived mesencymal cells, wherein the skin substitute is capable of inducing hair follicles that are morphologically-correct and are useful in any application requiring hair follicle formation/neogenesis, or in any condition where hair follicle formation/neogenesis is desired. "

    "hair follicles that are morphologically-correct "

    It's a really good thing that US army work on that HF neogenesis, they have unlimited money and we know many of inventions were used by army before and then came mainstream.

    And as we can see in this link, army begin trial soon for 3D printed skin (skin with sweat glands, appropriate pigmentation, and hair follicles)


    gives hope!

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  • Renee
    replied
    Here is the latest patent by the same group filed in 2014.

    This invention provides compositions in the form of skin substitutes comprising epithelial cells and mesenchymal cells, wherein the mesenchymal cells are not isolated from the occipital or nape region of the scalp, as well as methods for using the same.

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  • US government owned patent on hair follicle neogensis

    This invention provides a skin substitute comprising epithelial cells and modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells, and methods for using the same. This invention also provides a method for transplanting cells capable of inducing hair follicles, comprising subdermally or intradermally delivering to a patient modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells.
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