US government owned patent on hair follicle neogensis

[lacazette]

The first patent is from 2011, and explain what they will need for functional skin graft. (made any claims)

The second patent is deposed on May 1, 2014, and they explain in details how their compositions/methods fills these needs

[Sogeking]

Yeah this is military first patent was filed in 2011. And this is just a patent not sure if the skin that is written about in the patent is actually that functional.

However this might come to market in a few years or two decades. They are not in a hurry to commercialize it.

[lacazette]

Omg look at that other quote dudes

[089] The invention also provides a pharmaceutical composition comprising human dermal papilla cells and human keratinocytes, optionally in combination with collagen, for use in treating a subject who is at risk for, diagnosed with, or who has hair loss or is in need of hair follicle neogenesis



!!!

And this one explains what do they mean when they used the expression "morphologically correct" :

"hair follicles that have a normal configuration with an epithelial filament coming out of the distal end of the follicle and dermal papilla sitting at the base of the follicle. The follicles also have ceils proliferating at the base of the follicle, and have concentric layers of outer and inner root sheath, cuticle and cortex.
The follicles exhibit normal differentiation of the outer root sheath, and have hair shafts and sebaceous glands. The hairs go through normal cycles, and contain an epithelial stem cell component"


Am I dreaming guys??? ))

[It's2014ComeOnAlready]

Today it's just got a majority vote and thus will heading to the presidents table and I think it's heavily supported. Not that I know much about American politics.

It passed the house with 82% of votes (344/421), now it's on to the Senate. After it's passed in the Senate, it goes to the President's desk to be signed into law.

The importance here is that it has A LOT of support from both sides. Given the political climate we've seen recently, it sends a powerful statement with this much support.

[JayM]

If you google the bill it says that funding may hold it up, so there's no guarantee that it's going through...

Today it's just got a majority vote and thus will heading to the presidents table and I think it's heavily supported. Not that I know much about American politics.

[Renee]

The military does it's own separate clnical trials here is one site: http://www.clinicaltrials.army.mil

[Slam1523]

Not to mention the new bill being passed. Has it been decided yet? Because these treatments certainly come under life saving

If you google the bill it says that funding may hold it up, so there's no guarantee that it's going through...

[baldybald]

This is very interesting!

[Trouse5858]

So if they're going to be bio engineering the follicles does that mean that maybe they'll be able to actively select the types of characteristics (diameter/ thickness, curviness, pigment, etc.) that make up the hair itself? That would be ridiculously awesome..

[JayM]

Not to mention the new bill being passed. Has it been decided yet? Because these treatments certainly come under life saving

[lacazette]

Really near future for US soldiers with burned, wounded face and scalp. So we will see soon if they really growing new functional hair as they are claiming in their patent.

Army research are in several FDA clinical trials regarding skin regenerative medecine. And the patent mentions a lot that their invention will be useful for hair loss.
First for their burned soldiers, but with 21st century cure bill and the fact that this is an invention for life-threatening thing. The trials could take less time.
And if accepted by the fda for the injuried soldiers, that would mean the major FDA issues would be solved so when it'll come to civil use, it will be really faster for fda approval than a novel drug/therapy coming from nowhere from a private company

When I read those quotes from US army research, I think we can have hope:
"Expanding the technology to a greater number of potential patients will also help to ensure its long-term viability, Romanko said. “This has very widespread use, not only to the military audience, but also to the civilian population. We need a larger commercialization audience in order to be a self-sustaining technology,”

"In addition to surgical burn treatment and rehabilitation, the center is participating in several clinical trials to advance skin treatments.
“We’re currently a part of two major regenerative multi-center trials,” King said. “And they are sponsored in part by the Department of Defense. (Another) group is also (involved), they’re called AFRIM, Armed Forces Institute of Regenerative Medicine — that’s a partnership between the Department of Defense and civilian entities.”

"The AFIRM is a multi-institutional, interdisciplinary network of universities, military laboratories and investigators under the framework of a cooperative agreement, Romanko said. The network is designed to promote integration of development, from basic science research through translational and clinical research, as the best means of bringing regenerative médicine therapies to practice.

""About 30 universities, hospitals and additional partners, led by the Wake Forest Institute for Regenerative Medicine, make up the consortium of AFIRM researchers. Romanko works with the TIRM PMO, which supports AFIRM and other regenerative medicine programs. AFIRM receives funding from the U.S. Army, the Offce of Naval Research, Air Force Surgeon General’s Offce, Veterans Health Administration, National Institutes of Health and the Offce of Assistant Secretary of Defense for Health Affairs. AFIRM investigators also bring in funding from other federal, state and private sources."

[FooFighter]

Why someone from USA don’t call them and ask? Don’t be shy guys...

[Arieux]

That's very impressive, I have never heard about this project and I didn't find any news about it on other hair loss sites. Are there any plans to continue this research and make it available in near future?

[lacazette]

I agree, Jay, there's a lot of hairloss references in the patent and it claims many times (in short): 'this invention is useful to treat FULL hair loss'.
So they know it will not be useful just for skin grafts on burned patients, and the sentence you quote about hair industry just proove that thing.
they know they have gold in their hand, for sure.

other interesting quotes:

"methods are disclosed herein for transplanting cells capable of inducing human hair follicles to a subject, comprising delivering to a human subject any of the microspheres described above. In some embodiments, the microsphere is subdermally or intradermally delivered to a subject."
two approaches to deliver the cells that will induce human HF

"Also disclosed herein are the microspheres described above for use in the manufacture of a medicament for inducing hair follicle formation or for inducing hair follicle neogenesis in a subject
"

those little quotes are good also, they talk about anagen,telogen,etc, their hair are cycling and are morphologically-correct

"Fig. 15B provides a magnified view showing the presence of pigmented hair shafts."

"after 15 weeks, Figs. 16A-C show telogen hair follicles, confirmed by club-like appearance and spiky keratin fibers(Fig. 18A), secondary hair germ with adjacent hair papilla (Fig. 16B), and presence of a cornified club "

"Fig. 17B shows an anagen hair follicle with dermal papilla (arrow), including dense Ki- 67 reactivity. "


[059] In some embodiments, a subject in need of inducing hair follicle growth has partial-thickness skin loss, full-thickness skin loss, a wound, a burn, a scar, or hair loss...

I just stop at the middle of the patent, but all I read in it for the moment is just what I was dreaming to read for years hehe

[JayM]

" In addition, hair restoration is one of the fastest growing areas of cosmetic therapies for both men and women. "

This is the most important sentence for me. It shows that this therapy isn't just for burn victims or people who need skin grafts and wont just be used in the military. It shows that they plan to expand and offer this to the public.

Talking about Cotsarelis, do we know if any of these scientist worked with him before? Could be a possibility. Or maybe he just gave up the game because he was piped to it by US army?

@hellouser you know a lot about his research any insight?