US government owned patent on hair follicle neogensis

[lacazette]

[0131] The most common form of hair loss is a progressive hair thinning condition called androgenic alopecia. Hair loss can occur on any part of the body and can arise from any number of factors. For example, traction alopecia is most commoniy found in people who pull on their hair with excessive force into ponytails or cornrows. Alopecia areata is an autoimmune disorder that can result in hair loss in just one location (alopecia areata monolocularis), or can result in the loss of every hair on the entire body (alopecia areata universalis). Hypothyroidism, tumors, and skin outgrowths (such as cysts) also induce localized baldness. Hair loss can also be caused by chemotherapy, radiation therapy, childbirth, major surgery, poisoning, mycotic infections, and severe stress. In addition, iron deficiency is a common cause of hair thinning. In many cases of hair loss, the hair follicles have stopped cycling and have entered a quiescent stage. In other cases, the hair follicles are lost completely, or never formed in the first place.
[0132] The compositions and methods of the invention are useful for treating any condition requiring growth of hair follicles.

[lacazette]

Hey Desmond

What is interesting is that the main objective of this US army research is to treat their injuried burned soldiers, who live nightmares with the current skin grafts method

And the most crucial point to create new good skin, is the follicle neogenesis that lead to a functional hair follicle.
So the best researchers with the best technologies and without funding problems, worked exactly on the point that we hairloss sufferers needed. (we are lucky^^)

Since aderans the progress on regenerative medecine knowledge,methods and technologies is unbelievable fast all over the world and concerns all the human diseases. And it's exponential hehe

I agree with you on not to be too excited until the results of their skin graft and mpb trial.
But in my case i can't, cause it's not a private company trying to treat hair loss.
It's the stronger army in the world who tried to find a solution for their 30% of injuried soldiers that are suffering, and some have nightmare lives, and don't have current solutions.

And luckily for us, to find this solution, they had to work exactly on what we needed

So in my opinion, like unlimited times before in history, the keys for an invention will comes from army and military use

Of course it will take time, but they enrolling right now for a mpb trial, so we won't wait that long to see if their inventions confirms its success

[Desmond84]

Good find

Wow, this is definitely some exciting stuff. Another branch of Wakeford is working with DARPA on "skin-on-a-chip" technology, with similar aims.

But, if you wanna be realistic, don't get too excited when you see filed patents alone. They are not peer-reviewed research papers and are simply claims made by a company. The best example is Aderans Research Institute. They have been filing very similar patents to the ones on this thread since 2002 and have failed miserably to reproduce their claims in a human patient. Here's a link to one of their patents:

http://www.faqs.org/patents/app/20150113672

[0008] Reconstituted human skin containing cycling mature human hair follicles which produce normal pigmented hair shafts has been created. The reconstituted human skin contains a full subcutis layer, and hair follicles that form therein that grow in a distinctive pattern seen in the skin from which the cells are derived. The skin is created by obtaining multipotent and differentiated epidermal cells and differentiated dermal cells, culturing the epidermal and dermal cells/multipotent cells separately and separately passaging the proliferated cells, mixing the cells together to form a cell suspension, applying the suspension to an inert biocompatible substrate suitable for attachment of cells such as a slightly permeable silicone membrane, allowing the cells to attach to the substrate, typically about one to two hours, then applying the attached cells to full thickness wounds of small dimension. The ratio of multipotent and differentiated epidermal cells is in the range from 1:1 to 10:1. Areas to be implanted with cultured cells to form hair follicles are typically prepared using a one to two mm punch biopsy. The areas into which the cells are to be implanted may be as large as 0.5 to 2 cm2 and between 0.6 and 0.8 cm deep, however. The substrate is secured to the site to insure the cells remain within the wound site. Reconstituted skin covering an area of 0.1-2 cm2 may hold from 50-2000 mature hair follicles per cm2.

[Slam1523]

...im not 1% as well read as 99% of you. but the trials for this are being conducted to discover the best application and dosage of the product. so ofcourse that verdict isn't out because it's not even done yet.

That was kind of my point...

[jpar]

...im not 1% as well read as 99% of you. but the trials for this are being conducted to discover the best application and dosage of the product. so ofcourse that verdict isn't out because it's not even done yet.

[Slam1523]

This is technology and patent backed by US military with unlimited amounts of capital and best researchers. Members who understand scientific terminology can read the patents and provide their comments. Members were all over that follicept and we all know how that turned out!

First off it isn't going to be unlimited, the government allots a certain amount of funding, and none of us know how much that actually is. Follicept provided a step by step application, as well as the content of their product... If you can provide EXACT information with regards to application, dosage, and contents of the product, at that point you can start expecting feedback.

[lacazette]

Hemo, Sogeking

Any scientists before had find how to grow 'morphologically correct' hair follicle with normal cycling ! Come on guys Wake up !

It's what Cotsarelis tried to find for more than 10 years!! ( and interesting thing is that Cotsarelis participated in a study on neogenesis in 2013 with the 3 researchers of this US army patent) I think he was really sad when he saw this patent come out x)

[Sogeking]

There's not much to criticize...no one is marketing a product or anything, a user simply found some patents that seem interesting and promising. There's also no evidence of if/when it's going to market, so again, not much to get worked up over, either positively or negatively.

Yup that is exactly what I said in earlier post. Something can come out of this in 2 years or 2 decades. There is just no telling. It could mean the cure or it could mean nothing at all.

[Renee]

This is technology and patent backed by US military with unlimited amounts of capital and best researchers. Members who understand scientific terminology can read the patents and provide their comments. Members were all over that follicept and we all know how that turned out!

[lacazette]

Never saw patents with that kind of claims! Especially regarding neogenesis!
And it's from the best researchers with the best technologies in the world. And with multi foundings from multi institutions

And there's a clinical trial for mpb by Wake Forest that are enrolling right now!

In my case it's just the best thing I read in about 10 years! Nothing compared to anything before

[Hemo]

Interesting to see 0 feedback from any of the veteran-sceptics on this forum.... and they are definitely the overwhelming majority

There's not much to criticize...no one is marketing a product or anything, a user simply found some patents that seem interesting and promising. There's also no evidence of if/when it's going to market, so again, not much to get worked up over, either positively or negatively.

[JayM]

Renee, Nohawk, what are you doing?! shhhhhhh haha. Maybe it's at a point where people just are so tired and having this little hope is nice?

But it's great that you applied jpar. Guys is anyone else on this forum that close? I would jump at this opportunity.

And to be fair out of it all the hair loss industry is the biggest so what better way to fund expanding the resources needed for skin grafts ect than tapping into the biggest market going, because this will include women as well. It also sounds like not a cure but a reversal of symptoms so for them until a cure is found it would be an investment in every single balding generation.

[Slam1523]

It's a patent, it doesn't give any sort of timeline, or any results yet, so what would the skeptics talk about? I think anyone that's been on these forms for a few years knows how these patents come and go with no progress... All you can do is hope, but be realistic along with that!

[Renee]

Nohawk you took the words right out of my mouth. It's amazing members are not raving about this.

[nohawk]

Interesting to see 0 feedback from any of the veteran-sceptics on this forum.... and they are definitely the overwhelming majority