2015 outlook.

[KO1]

Yeah it's one thing to be interested in these things from a scientific POV, but foolish to base a treatment plan around it. Personally, I thought Follica was the best player in the game, and they have basically shut down, aderans was another A player, but failed as well. Replicel is a B player as is Histogen. (Seti has nothing to do with Follica btw).

More on topic, I think that Seti is an incomplete treatment even looking at it from Cots POV. We are only inhibiting PGD2, but according to their own yin yang theory, we need to be promoting PGE2 (it is already available as a drug). I think SM is the most interesting treatment, there's a lot of evidence for Wnt in treating hair, and it's been demonstrated on men not mice, and this is far more potent. Given that we lack growth stims, it could be pretty useful, and reenergize Follicas wounding modality, as it's surely more potent than topical lithium.

[Keki]

[QUOTE=Swooping;201047 Take follicept as an example, they have good intentions. But the fact that people are already hyped up shows me how incredibly desperate people are up the point that they can’t think rationally. Based on what are they hyped? A rodent model lol. [/QUOTE]

A rodent model or a team of dedicate and honest people, well more "educated" then you who wake up in the morning thinking a way to make follicept works to improve people life, and it doesn't matter if actually works or not, they at least tried, unlike people like you who doesn't make anything productive other then mark people desperate just for being excited to see something positive in a conversation with the owner of a startup.
maybe i'm naive, stupid, or ignorant for you, i don't care what you think about me, i'm happy behind the labs there are people not afraid to be wrong
One side we have a nobody on internet who read a bunch of sites and publications with some crap like you can't beat the korean nano formulation and needle, the other one we have a start up who have a brand new vehicle, time will tell, the only desperate are usually the brand new HT patient users who think there is no pharmacological therapy in the next future. Oh look we have one, you are right, it's so easy to choose who trust

[Swooping]

Yeah it's one thing to be interested in these things from a scientific POV, but foolish to base a treatment plan around it. Personally, I thought Follica was the best player in the game, and they have basically shut down, aderans was another A player, but failed as well. Replicel is a B player as is Histogen. (Seti has nothing to do with Follica btw).

Exactly. You can obviously be excited too when you see real evidence imo. But there is no evidence as yet to speak. The evidence that is portrayed and given out by the companies don't show good results. There is no sugarcoating possible for it.

A rodent model or a team of dedicate and honest people, well more "educated" then you who wake up in the morning thinking a way to make follicept works to improve people life, and it doesn't matter if actually works or not, they at least tried, unlike people like you who doesn't make anything productive other then mark people desperate just for being excited to see something positive in a conversation with the owner of a startup.
maybe i'm naive, stupid, or ignorant for you, i don't care what you think about me, i'm happy behind the labs there are people not afraid to be wrong
One side we have a nobody on internet who read a bunch of sites and publications with some crap like you can't beat the korean nano formulation and needle, the other one we have a start up who have a brand new vehicle, time will tell, the only desperate are usually the brand new HT patient users who think there is no pharmacological therapy in the next future. Oh look we have one, you are right, it's so easy to choose who trust

Yeah you sure are;

i "donated" so much money over the years in snake oil, shampoo, supplements that i don't really mind few euro donated

And then people wonder why the process of getting better treatments is even slower and more out of reach. It is exactly because of people like you. Ignorant, naive consumers who get dictated and manipulated like a little puppy. Hilarious .

[Keki]

ahaha i exagerrated, i never bought any snake oil in my life anyway, just the expensive aminexil when i was too young to even think or read about AGA, i have no money to waste anyway and i buy only proven products, i'm still finishing uni and i don't work so i can't be "the manipulated consumer" you think i am, thx god i'm smart enough to understand who you are, a failure of man desperate to think there is no solution because it never worked for you, and fool enough to think you have mastered the medicine enough to mock real researcher working in follicept and Seti, BUT the funny part is that you are still using RU, an experimental, not approved, with no real extensive trials behind and maybe dangerous, how hypocrite are you? LOL

[Swooping]

ahaha i exagerrated, i never bought any snake oil in my life anyway, just the expensive aminexil when i was too young to even think or read about AGA, i have no money to waste anyway and i buy only proven products, i'm still finishing uni and i don't work so i can't be "the manipulated consumer" you think i am, thx god i'm smart enough to understand who you are, a failure of man desperate to think there is no solution because it never worked for you, and fool enough to think you have mastered the medicine enough to mock real researcher working in follicept and Seti, BUT the funny part is that you are still using RU, an experimental, not approved, with no real extensive trials behind and maybe dangerous, how hypocrite are you? LOL

Sure you did . I’m a failure of a man? Oehw, you almost hurt me babe. Typical of someone who can't bring on arguments, he takes it on a personal level. How cute is that. Besides that things do work for me. Things do work for almost everyone. Finasteride does work, minoxidil does work. They are both approved. In what world do you live?

Preventative cures are available to everyone. So sorry, treatments do work for me and never failed me. The only thing that I wished for is that I used them earlier in my life. I would be sitting with a better density of hair now. I think many people can emphasize with me on that. Still I'm very happy with the state of my hair, would even still be happy if I would be bald.

Yes I use RU it’s a topical anti-androgen and it’s validated that AR antagonizing works. The whole pathology of AGA is centered around the androgen receptor. Without AR transcription AGA can't occur. No real trials? Human trials were run into phase 2 of RU, just shows how much you know. And you think you “think” and read about “AGA”. You know shit lol. That’s why you buy into snake oils and magical stories. Seems you don’t even understand the definition of a “hypocrite”. Come back when you can actually hold ground in a debate.

[Keki]

Debate? I don't want to debate anything with you, i just want to gives the lurkers some background on your persona, i don't want to persuade you and you don't have to convince me anything, everyone has a story, i have spent hundreads of hours over the years to study aga and learn from people who actually know something, and i had the opportunity to talk with top notch researcher, way smarter then me and you, and that gave me some idea what the next real working treatment could be and luckly for us all this new treatments have the POTENTIAL to really work, that's why they are developed and supported, but people alredy noticed this and for this reason there is a lot of entusiasm all over the world for the next years, less with negative toxic troll that can be found only in hairloss community
We could debate about RU and the trials but i don't care (but it was funny to read you write about the phase 2, i admit that), i just want encurage people to do they own research and study, with past and future solutions and a egocentric mr nobody with no scientific background, HYPOCRITE and with zero credibility, who really know a shit about how and what things works have no right to mock and insult people just for asking questions or to hype some new product when it has legit people and legit science behind but classify this with a snake oils and magical shit, so pathetic

This is my last post about you anyway, it's pointless

[Swooping]

Debate? I don't want to debate anything with you, i just want to gives the lurkers some background on your persona, i don't want to persuade you and you don't have to convince me anything, everyone has a story, i have spent hundreads of hours over the years to study aga and learn from people who actually know something, and i had the opportunity to talk with top notch researcher, way smarter then me and you, and that gave me some idea what the next real working treatment could be and luckly for us all this new treatments have the POTENTIAL to really work, that's why they are developed and supported, but people alredy noticed this and for this reason there is a lot of entusiasm all over the world for the next years, less with negative toxic troll that can be found only in hairloss community

Look someone who actually needs to prove himself over the internet about what of a fabulous person he is. I wish I could be you goddamn . I really do.

Anyway, enlighten us with statistical evidence about this upcoming treatment(s) which shows good result and is going to hit the market. Perhaps I have missed something. Give us your "legit" science, come on man. I'll be eagerly waiting for your response!

[dus]

Get a room you two.

[Illusion]

A rodent model or a team of dedicate and honest people, well more "educated" then you who wake up in the morning thinking a way to make follicept works to improve people life, and it doesn't matter if actually works or not, they at least tried

Uh regarding the bolded part, that's not really how companies roll

[Illusion]

Get a room you two.

Solid first post (;

[Keki]

Uh regarding the bolded part, that's not really how companies roll

Ofc they made a company to make money, but i don't see a team of university researcher motivated just by the thought of milking the bald community or give us a scam, we have a face and a name that give us both good and bad news, they are honest passionate and confident people and i hope they succeed in the near future even if follicep will be a fail

[It's2014ComeOnAlready]

Would like to comment about bimatoprost, because there has been some misinformation being spread around. To set the record straight, what has been going on is that they showed results similar to minoxidil in their phase 2a studies. In 2b, they used 10X (1000% higher) the concentration they previously used. They did this because they believe in the compound.

Phase 2b was completed in January, and in articles it was said that if anything positive was shown (significant superiority to minoxidil) they would immediately gear up for a phase 3 as soon as 2b was done. Spencer Kobren himself had confirmed he heard that the results were excellent, and would be a new, extremely effective treatment. On the clinical trials page for this drug, it says "study is ongoing but not recruiting participants." There is no mention of phase 3 on this page, but it was stated earlier by their CEO that they would immediately jump into a phase 3 if positive results were shown. This drug has been shown to be somewhat effective at an extremely low concentration - 0.03%. They have been testing 1-10%. Anyone who understands math, knows that this exponentially higher.

There are naysayers in regard to this treatment, and any new promising treatments, but they are perpetually angry and don't believe anything good will come of them. Ignore them, they are wrong. The chief medical officer of Kythera used to work at Allergan for many years. The only drug in Kythera's pipeline is Setipiprant for hair loss, it is their future. Companies don't take this kind of gamble without assurances. If it were to fail, it could crush their company. Keep in mind both bimatoprost and setipiprant have an effect on prostaglandins, and if successful, will be a paradigm-shift in hair loss prevention and treatment. Better treatments are coming and these two are the ones to look forward to the most. Pay attention to the science, not the arrogant armchair scientist posters who, because they have a voice on this forum believe they have the authority to deny scientific discoveries and the companies who spend tens of millions of dollars to bring them to fruition. Ask yourself, would you just gamble away tens of millions on crap? The answer is no, and neither would these companies.

[KO1]

If Setipiprant fails, it will not crush their company, this is just one drug in their pipeline, they are going to be focusing on making money off that double chin.

That gets me thinking...maybe I could use that drug too!

[It's2014ComeOnAlready]

If Setipiprant fails, it will not crush their company, this is just one drug in their pipeline, they are going to be focusing on making money off that double chin.

That gets me thinking...maybe I could use that drug too!

No, it would be disastrous. It would mean that they would have NOTHING to show for themselves over a period of years (which is how long it will take to get through clinical trials). Also, consider the loss of tens of millions of dollars being spent on clinical trials. Their only drug would be one that is rivaled by diet and exercise.

[tf2legend]

Anyway, enlighten us with statistical evidence about this upcoming treatment(s) which shows good result and is going to hit the market. Perhaps I have missed something. Give us your "legit" science, come on man. I'll be eagerly waiting for your response!

Swooping you dont sound too optimistic about these future/possible treatments (specifically follicept) that may hit the market in the near future. Can I ask you why you think follicept wont work with its IGF delivery? Hasnt there been evidence that shows IGF works or am I missing something here?

I am cautiously optimistic about it mainly because of the team they have down there but I am not very informed with this IGF and the trials that have been conducted in the past